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Showing 1 to 20 of 20 for “"Poly(ethylene glycol) diacrylate"”.
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INVESTIGATION OF THE MECHANICAL PROPERTIES OF POLY (ETHYLENE GLYCOL) DIACRYLATE BY NANOINDENTATION USING ATOMIC FORCE MICROSCOPY
Poly (ethylene glycol) (PEG) hydrogel based polymers are among the most widely used synthetic materials for biomedical applications. Because of their biocompatibility, and ease of fabrication, hydrogels are highly suitable for use as constructs to engineer tissues as well as for cell …
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Promotion and control of angiogenic activity in poly(ethylene glycol) diacrylate hydrogels for tissue engineering applications
… an angiogenic-signaling protein or peptide to poly(ethylene glycol) diacrylate hydrogels, thereby yielding a system which can be used to develop vascularized, functional engineered tissues. The field of tissue engineering has the capability of providing greatly needed biological organs and …
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Degradable nanocomposite preformed particle gel for chemical enhanced oil recovery applications
… hydrogels are recommended for secondary polymer flooding, since they have the highest post-degradation viscosity under anaerobic conditions.</p><p>The second product is an elastomeric rubber gel as a potential fracture-sealing agent. An elastomeric rubber gel has been synthesized from …
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Development of collagen-based scaffolds for differentiation of induced pluripotent stem cells
… scaffolds were developed by fabricating poly(ethylene glycol) diacrylate (PEGDA) into the collagen hydrogel to form an interpenetrating network (IPN). Stability test showed significant improvement of shrinkage resistance compared to pure collagen hydrogel. Assessment of biocompatibility …
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Visible Light Cured Thiol-vinyl Hydrogels with Tunable Gelation and Degradation
Hydrogels prepared from photopolymerization have been widely used in many biomedical applications. Ultraviolet (200-400 nm) or visible (400-800 nm) light can interact with light-sensitive compounds called photoinitiators to form radical species that trigger photopolylmerization. Since UV light has …
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Cell-cell communication in three dimensional microenvironments
… found in natural tissues, hydrogel scaffolds of poly (ethylene glycol) diacrylate and the basement membrane matrix Matrigel were used. Optical tweezer technology allowed precision placement and formation of homotypic and heterotypic arrays of human U937, HEK 293, and porcine mesenchymal stem …
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Time-Lapse Polymerizations Triggered by pH clock Reactions
The theme of this work is time-lapse polymerizations triggered by pH clock reactions. The first chapter is the introduction and gives a long overview of the different chemistries studied here. The second chapter focuses on the bromate-sulfite clock reaction. Based on some simplified and accepted …
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Imparting Functionality to Macromolecules for Selective Stimulus Response
Polymeric materials with inherent stimulus response represent an ever-growing area of research. In particular, block copolymers demonstrate exciting properties owing to their enhanced mechanical strength and microphase separation. Incorporating functionality into block copolymers proves useful in …
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Elucidating Cause-Effect Relationships between Extracellular Matrix Signaling and Mesenchymal Stem Cell Differentiation
… and osteogenic MSC differentiation using poly(ethylene glycol) diacrylate (PEGDA) hydrogels as a material platform. First, the effect of several ECM proteins associated with bone morphogenesis or bone fracture healing on MSC osteogenesis was investigated. Second, collagen-mimetic proteins …
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Evaluation of Biomimetic and Alloy-based Materials for Orthopedic Applications
… hydrogel systems presented in this manuscript, poly(ethylene glycol) diacrylate (PEGDA) networks were selected as the base scaffold due to the broad tunability of their mechanical properties and their previous use in bone regeneration applications. In addition, pure PEGDA hydrogels do not …
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Digital Manufacturing Techniques for Microfluidic Device Fabrication
… elastomeric, and biocompatible material called polydimethylsiloxane. However, this fabrication process is extremely labor intensive, time consuming, expensive, not amenable for high-throughput manufacturing, and makes commercialization of microfluidic devices difficult. Digital manufacturing …
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Engineering scaffold and soluble cues for cell-instruction
… research, we fabricated stiff and metastable poly(ethylene glycol diacrylate)-polyethylenimine hydrogels for the release of cytokines in vivo (chapter 7). The high stiffness of the material, attained from the highly branched architecture of polyethylenimine, allowed the hydrogel to release …
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Designing Scaffolds for Directed Cell Response in Tissue Engineering Scaffolds Fabricated by Vat Photopolymerization
Vat photopolymerization (VP) is an additive manufacturing (AM) technology that permits the fabrication of parts with complex geometries and feature sizes as small as a few microns. These attributes make VP an attractive option for the fabrication of scaffolds for tissue engineering. However, there …
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Advanced in situ hydrogel assembly for guiding molecular release
… additional chemical modification of gel-forming polymers. However, these approaches often encountered several challenges including the instability of molecular cargos, the extensive labor of synthesis and purification, and the uncontrollability of the molecular release direction. In contrast, …
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Computational modeling-guided printing of proangiogenic hydrogel for vascular patterning
… To examine this hypothesis, I printed multiple poly(ethylene glycol) diacrylate (PEGDA) hydrogel strips loaded with vascular endothelial growth factor (VEGF) using an ink-jet printer. The viscosity and surface tension of the pre-gel PEGDA solution were optimized to fabricate the gel with desired …
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Imaging biological water permeability barriers using CARS microscopy
… hydrogel imaging phantom was constructed from poly(ethylene glycol) diacrylate (PEGDA) to validate ability of water-CARS microscopy to determine the relative permeability differences of adjacent material layers. By imaging the dynamic and steady-state H2O and D2O exchange across the uniform and …
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Reverse-selective gas-separation membranes prepared by atom transfer radical polymerization
… membranes containing thin poly(ethylene oxide) (PEO)–based polymer films grown from porous substrates via surface–initiated atom transfer radical polymerization (ATRP). PEO has an excellent CO<sub>2</sub> solubility, but crystallization of PEO chains leads to low …
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Engineering the micro-environment to control the fate of mammalian cells
… stiffness were combined in a three dimensional poly ethylene glycol diacrylate hydrogel to truly mimic the native tissue. Stereolithography apparatus enabled modulating the stiffness of the substrate by controlling the degree of polymerization of the different polymers. Dielectrophoresis helped …
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New Solid Polymer Electrolytes for Lithium, Sodium, and Calcium-based Batteries
… the transport of these alternative ions in their polymer counterparts remains understudied. The advantages of solid polymer electrolytes include the possibility of higher energy density in solid-state devices and the elimination of safety concerns associated with liquid electrolytes, such as …