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Showing 1 to 20 of 202 for “"Poly(ethylene glycol)"”.
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Enzymatically crosslinked poly(ethylene glycol) hydrogels for tissue engineering
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1999.
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Poly(ethylene glycol) hydrogel microspheres as a controlled release device
… an immunization site by fabricating crosslinked polyethylene glycol hydrogel microspheres that encapsulate a chemoattractant. This study was performed to determine whether the diffusion of the chemoattractant could be controlled by varying the amount of crosslinker and by incorporating ionic …
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Patterning Strategies of Poly(ethylene glycol) Based Hydroxyapatite Composites for Biomedical Applications
… und vergleichend zu untersuchen. Daher wurden Poly(ethylen glykol) basierte Hydrogele und HAp eingesetzt um verschiedene inorganisch-organische Hydrogel Komposite zu formen. Dabei war es Ziel, das intrinsische proteinabweisende Verhalten von PEG basierten Hydrogelen und die proteinanziehenden …
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Synthesis of alkyl- and poly(ethylene)glycol linked bis-dioxocyclams from bis-chromium carbene complexes
… were unsuccessful. Both tri- and tetra(ethylene glycol) linked bis-chromium carbene complexes have been synthesized. These carbene complexes were photolyzed with imidazolines to give protected azapenams. The azapenams were transformed into polyether-linked basket dioxocyclams and …
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The Degradation and Drug Release Mechanisms of Poly(ethylene glycol)-functionalised Poly(L-lactide) Polymers
Poly(L-lactide) (PLLA) is a well-recognised bioresorbable polymer known to degrade after 1.5 to 5 years by hydrolysis. For certain medical device or drug delivery applications, it would be desirable to reduce this degradation time as strategies for tailoring degradation and drug release rates …
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Engineering mechanical dissipation in solid poly(ethylene glycol) hydrogels with bio-inspired metal-coordinate crosslinks
… crosslink chemistry balance, we synthesized polyethylene glycol (PEG) hydrogels with two crosslinked networks; a primary permanent network composed of covalently crosslinked 4-arm PEG and a secondary network composed of 4-arm PEG functionalized with histidine on each arm. The histidine …
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Bioresorbable Electrospun Tissue Scaffolds of Poly(ethylene glycol-b-lactide) Copolymers for Bone Tissue Engineering
Poly(α-hydroxy esters) are a class of biocompatible resorbable polyesters including poly(lactic acid) (PLA) and poly(glycolic acid) (PGA) that are FDA-approved for clinical use. Preliminary tissue culture studies have demonstrated that these poly(α-hydroxy esters) support bone tissue development …
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INVESTIGATION OF THE MECHANICAL PROPERTIES OF POLY (ETHYLENE GLYCOL) DIACRYLATE BY NANOINDENTATION USING ATOMIC FORCE MICROSCOPY
Poly (ethylene glycol) (PEG) hydrogel based polymers are among the most widely used synthetic materials for biomedical applications. Because of their biocompatibility, and ease of fabrication, hydrogels are highly suitable for use as constructs to engineer tissues as well as for cell …
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Promotion and control of angiogenic activity in poly(ethylene glycol) diacrylate hydrogels for tissue engineering applications
… an angiogenic-signaling protein or peptide to poly(ethylene glycol) diacrylate hydrogels, thereby yielding a system which can be used to develop vascularized, functional engineered tissues. The field of tissue engineering has the capability of providing greatly needed biological organs and …
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Factors Affecting Size and Swelling of Poly(ethylene glycol) Hydrogel Microspheres Formed in Aqueous Sodium Sulfate Solutions
… critical solution temperature: LCST) behavior of poly(ethylene glycol): PEG) in aqueous sodium sulfate solutions was exploited to fabricate hydrogel microspheres under mild conditions without the use of other monomers, polymers, surfactants or organic solvents. Reactive PEG derivatives underwent …
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Improving Biocompatibility By Controlling Protein Adsorption: Modification And Design Of Biomaterials Using Poly(Ethylene Glycol) Microgels And Microspheres
… is described for the covalent attachment of poly(ethylene glycol): PEG)-based hydrogel coatings onto biomaterials surfaces for the minimization of protein adsorption. The coatings are applied using partially crosslinked PEG solutions containing polymer and protein oligomers and microgels that …
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Ion Transport, Viscoelastic, and Thermal Properties of Several Poly(Ethylene Glycol) and Poly(Propylene Glycol) Based Polymer Electrolytes
… properties of several MePEG and MePPG based copolymer electrolytes. In particular two main copolymer modifications have been investigated namely copolymerization with "bulky groups" and cross polymerization of MePEG and MePPG monomers. The modifications were made to vary the fractional free …
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Engineering poly(ethylene glycol) nanogel coatings: Developments in achieving ultralow protein adsorption and applications as substrates for stem cell culture
… ultralow protein adsorbing surfaces formed from poly(ethylene glycol) nanogel coatings of variable structural and chemical properties. We found that resistance to protein adsorption can be improved by increasing the nanogel coating's surface packing density, which is achievable using orthogonal …
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Surface Activity at the Air-Water Interface and Self-Stratification of Silica Nanoparticles Functionalized with Tri-Methoxy Poly(ethylene glycol) Silane
… (SNPs) have been functionalized with tri-methoxy poly(ethylene glycol) silane (mPEG silane), end-capped with a methyl group. This functionalization imparts surface activity at the air-water interface due to the hydrophobic nature of the end-capped methyl group. To determine the surface coverage of …
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Poly(ethylene glycol)-based open-channel blockers for the acetylcholine receptor : mechanistic and structure-function studies at the single-channel level
… proposed strategy utilizes the flexibility of a polymer backbone, poly(ethylene glycol) (PEG), to maximize blocker-pore interactions. A proof-of-concept study is presented for the muscle-type nicotinic acetylcholine receptor (AChR). Single-channel electrophysiological measurements with a series …
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