Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Poly(caprolactone)"”.
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Phase Behavior of Poly(Caprolactone) Based Polymer Blends As Langmuir Films at the Air/Water Interface
Poly (caprolactone) (PCL) has been widely studied as a model system for investigating polymer crystallization. In this thesis, PCL crystallization along with other phase transitions in PCL-based polymer blends are studied as Langmuir films at the air/water (A/W) interface. In order to understand …
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Biodegradable Thermoplastic Elastomers and Smart Composites
… literature of relevant background information on polymers, biomaterials, and previous biodegradable elastomers and responsive elastomeric systems. </p> <p>The first biodegradable elastomer developed and investigated, as presented in Chapter 2, is a novel thermoplastic polyurethane that has a …
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Modelling the movement of superparamagnetic beads engulfed in endothelial cells
… cells (HUVECs) within a micro-porous, poly-caprolactone scaffold is facilitated with superparamagnetic beads introduced to the cells by phagocytosis. It is shown that the dominant motion of the affected cells is determined by the viscous drag of the medium and the amount of coupling …
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Synthetic Degradable Polymer Systems for Drug Delivery
… hydrogel was prepared from methacrylate-capped poly(caprolactone-co-lactide)- poly(ethylene glycol)-poly(caprolactone-co-lactide) (M-PCLA-PEG-PCLA-M). The physical properties and drug release rates of the GSK3787-loaded hydrogel were studied. In addition, the in vivo treatment efficacy of the …
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Functional polymers for biomedical application : synthesis and applications
… It was anticipated the resulting functional polyamides would biodegrade to physiologically acceptable compounds and show pH dependant solubility could be used for biomedical applications ranging from enteric coatings to hydrosoluble drug delivery vehicles capable of targeting areas of low …
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Blends of Biodegradable Thermoplastics With Lignin Esters
Thermoplastic blends of several biodegradable polymers with lignin (L) and lignin esters were prepared by solvent casting and melt processing. Among the biodegradable thermoplastics were cellulose acetate butyrate (CAB), poly-hydroxybutyrate (PHB), poly-hydroxybutyrate-co-valerate (PHBV), and a …
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Microencapsulation studies with P(HB-HV) polymers
… these studies to prepare microparticles from poly--hydroxybutyrate homopolymers and copolymers thereof with 3-hydroxyvalerate [P(HB-HV) polymers]. Variations in the preparative technique have facilitated the manufacture of two structurally distinct forms of microparticle. Thus, monolithic …
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Alternative strategies to incorporate biomolecules within electrospun meshes for tissue enginering
… was co-axially electrospun on the shell side of poly caprolactone (PCL) and arginine-glycine-aspartate (RGD) was attached to the electrospun meshes. Bone marrow stromal cells (BMSCs) attached, spread and proliferated on these meshes. In the second approach, fluorescein isothiocyanate labelled …
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Effects of Polybenzoxazine on Properties of Shape-Memory Polyurethanes with Glassy and Crystalline Soft Segments
Shape memory polymers (SMPs) have attracted significant attention from both industrial and academic fields because of their useful and fascinating functional preperties. Of particular interests are shape memory polyurethane (SMPUs), which have strong potential in biomedical and consumer …
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
… This thesis focuses on developing the novel polymeric microneedle systems to deliver poorly soluble molecules intradermally in a sustained manner.<br/><br/><br/>In this thesis, amphotericin B, a model poorly soluble drug, was formulated using polymeric microneedle systems to achieve …
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Development of Polymer-Biomolecule Core-Shell Particles For Biomedical Applications
… strategies to introduce biomolecules around polymeric nanoparticles (NPs) is critical for targeted delivery of therapeutic or diagnostic agents. Although polymeric NPs have been well established, problems such as toxicity, stability, and immunoresistance remain potential concerns. The first …
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Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations
… early 2017. Additionally, the influence of the polymorphic form of fusidic acid on its stability was investigated. Fusidic acid is known to exist in 4 polymorphic modifications and this study has shown that polymorphic forms I and III are currently available on the commercial market. Intrinsic …
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Development of implantable devices for schizophrenia treatment
… RIS-loaded implants were developed using poly(caprolactone) (PCL), a biodegradable and biocompatible polymer. In addition, PCL was also combined with poly(ethylene glycol) (PEG) 600, PEG 3000, and Tween® 80 in order to modify drug release profiles. The obtained implants were subsequently …
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Polymer Electrolyte Discovery via Rational Design and High Throughput Methods
… of this work. In this thesis, we focus on solid polymer electrolytes, which have the potential to enable more energy-dense batteries, and display improved safety compared to the highly flammable and toxic liquid electrolytes in use today. We detail our work in two main areas: the rational design …
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Multiblock Thermoplastic Polyurethanes For Biomedical and Shape Memory Applications
<p>Polyurethanes are a class of polymers that are capable of tailoring the overall polymer structure and thus final properties by many factors. The great potential in tailoring polymer structures imparts PUs unique mechanical properties and good cytocompatibility, which make them good candidates …
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Topology and Telechelic Functionality Control in Polyester Design
… long-chain branched, and novel crosslinked polyesters for applications spanning from pressure sensitive adhesives to biomedical applications. Altering polymer topology and functionality using different synthetic strategies was enabled tailoring the thermomechanical, rheological, and adhesive …
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Enhanced surface functionality via plasma modification and plasma deposition techniques to create more biologically relevant materials
… functionalized surfaces on nanoparticles and polymeric scaffolds through the use of plasma modification and plasma enhanced chemical vapor deposition techniques. Specifically, this dissertation will focus on (1) plasma deposition of SiO2 barrier films on nanoparticle substrates; (2) surface …
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CONFINED LAYERED POLYMERIC SYSTEMS FOR PACKAGING ANDCAPACITOR APPLICATIONS
… of layers containing two or more alternating polymers. This dissertation focuses on the structure-property relationships in layered polymeric systems for applications including confined crystallization for high gas barrier applications and multilayer dielectric films for high energy density …
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The Versatility of Aluminum Systems: Ligand Transfer Agents and Polymerization Catalysts
… are studied in various contexts. During ethylene polymerization with LCu(II) catalysts in the presence of methylaluminoxane (MAO), ligand (L) transfer is observed from the copper centre to the aluminum centre present in MAO. In the α-diimine case, an (imino-amido)AlMe2 complex is formed by …
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Hyaline Cartilage versus Fibrocartilage Formation within Mechanically Loaded Cartilage Constructs: In Vitro and In Vivo Studies
… while being reinforced with 3D-printed poly-caprolactone (PCL) structures, and future to examine the effect of reinforcement on the consturct performance. The results demonstrated that a longer compression period did not increase cell population or ECM content of loaded unreinforced …