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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Poly(amidoamine)"”.
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Spectroscopic investigations of acrylodan dye interactions with poly(amidoamine) and poly(propyleneimine) dendrimers
… phenol blue, the first direct examination of the polyamidoamine (PAMAM) and polypropylenimine (PPI) dendrimer core cavities was reported by a previous research group member. This previous work revealed the need to further understand the sequestering abilities and host-guest properties of these …
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Synthese monodisperser, multifunktionaler Poly(amidoamine) und ihre Anwendung als nicht-virale Vektoren für die Gentherapie
… der Synthese monodisperser, multifunktionaler Poly(amidoamine) (PAAs). Die Klasse der PAAs ist besonders interessant für eine Anwendung im Bereich der Biomedizin, da sie meist nicht toxisch ist, eine sehr geringe Immunogenizität zeigt und eine erhöhte Zellmembranpermeabilität besitzt. …
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Synthesis and solution state self-assembly of linear-dendritic block copolymers
Linear-dendritic block copolymers consisting of a poly(styrene) linear block and poly(amidoamine) dendrimer block were synthesized and examined for their ability to self-assemble in both aqueous environments and organic/aqueous mixtures. These polymers were shown to assemble into vesicle structures …
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Influence on molecular geometry and chain conformation on properties of polyelectrolyte multilayers
… is a versatile technique for fabricating thin polymer films. This thesis compares the properties of LbLfilms composed of different weak polycations. Slight perturbations in film assembly conditions can lead to large differences in film properties. Polyion bacisity and architecture are less …
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Synthesis and modification of pamam dendrimers as histone replacement molecules
… Introduction gives an overview to the origins of polymer and dendrimer science, and describes the synthetic approaches and resulting properties of dendrimers together with their impact on biological systems. The preparation of poly(amidoamine) (PAMAM) dendrimers utilising a number of different …
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Surface Tethered PAMAM Dendrimers On Controlled Pore Glass As Color Release Sensors For Phosphates
<p>Poly(amidoamine) dendrimer (PAMAM) are highly branched macromolecules with reactive amine groups in their interior and exterior. PAMAM dendrimers were attached to controlled pore glass (CPG) surfaces in order to create new functionalized surfaces and used as platforms for UV-vis and fluorescent …
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Sensitive Detection of Foodborne E. coli O157:H7 by Dendrimer-aptamer Modified Microchannels - with RCA Signal Intensifications
… coli O157:H7. In the proposed detection system, poly(amidoamine (PAMAM) dendrimers are immobilized onto inner surfaces of polydimethyl siloxane (PDMS) microchannels to avoid non-specific binding and to provide more binding sites to subsequently conjugate capturing aptamers as recognition …
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Amphiphilic linear-dendritic block copolymers for drug delivery
Polymeric drug delivery systems have been widely used in the pharmaceutical industry. Such systems can solubilize and sequester hydrophobic drugs from degradation, thereby increasing circulation half-life and efficacy. However, there are still challenges in the design of drug delivery vehicles to …
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Weak intermolecular interactions as binding probes and analytical tools
Over the past several decades, polyelectrolytes have received a great deal of attention in supramolecular chemistry. Poly(amidoamine), or PAMAM, dendrimers are hyperbranched polyelectrolytes that can bind to small charged molecules through non-covalent interactions. These supramolecular structures …
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Polymeric Nanocarriers And Their Oral Inhalation Formulations For The Regional Delivery Of Nucleic Acids To The Lungs
… acids to the lungs; (iii) the design of siRNA-poly(amidoamine) (PAMAM) dendrimer conjugates. We demonstrate that both DNA and siRNA can be efficiently formulated in HFA-based pMDIs upon the development of novel particle engineering strategies to overcome issues associated with their size and …
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Pamam dendrimer-based therapeutic and diagnostic nanodevices
… sensitivity and specificity. Hydroxyl terminated poly(amidoamine) dendrimer (PAMAM-OH) was modified with a linker having amine group at the end and conjugated to two drugs, erythromycin (EM) and allopregnanonolne, respectively and evaluated in vitro. Both drugs were provided with a linker having …
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Sustained hydrogel-based delivery of RNA interference nanocomplexes for gene knockdown
… nanoparticles in combination with synthetic polyethylene glycol (PEG) and natural fibrin hydrogel scaffolds. Four siRNA nanocarriers were investigated for siRNA delivery, that is, fourth generation dendrimer nanoparticles poly(amidoamine) (D) and its modified version (MD) with PEG and a lipid …
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Photopolymerization-based signal amplification : mechanistic characterization and practical implementation
Polymerization-based signal amplification is an approach to biosensing that leverages the amplification inherent to radical polymerization to enhance signal associated with molecular recognition. This versatile technique has been implemented with a number of radical polymerization chemistries, …
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The characterisation of a recombinant cytosolic shuttle based on ricin toxin
… compared with a previously well-characterised polymer based drug delivery system. In order to make this comparison, a recombinant cargo protein was required. As gelonin (Gel) had been previously used as a cargo for poly(amidoamine) (PAA) mediated cytosolic delivery, three recombinant gelonin …
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EMISSIVE PEPTIDE NUCLEIC ACIDS (PNAS): POTENTIAL TOOLS FOR INNOVATIVE DIAGNOSTICS AND THERAPEUTICS
… Strand Displacement with a Thymine-Substituted Polyamide. 1991, 254, 1497-1499. https://www.science.org/doi/10.1126/science.1962210. (2) Egholm, M.; Buchardt, O.; Christensen, L.; Behrens, C.; Freier, S. M.; Driver, D. A.; Berg, R. H.; Kim, S. H.; Norden, B.; Nielsen, P. E. PNA hybridizes to …