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Showing 1 to 20 of 26 for “"Poly(L-lactic acid)"”.
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Study of poly (l-lactic acid)/poly (d-lactic acid) stereocomplex as nucleating agent for poly (l- lactic acid) crystallization
Poly (lactic acid) (PLA) is a biodegradable polymer with good renewability and processability. However, it has some drawbacks. The Poly (lactic acid) (PLA) stereocomplex formed via the interaction between optical isomers Poly (L-lactic acid) (PLLA) and Poly (D-lactic acid) (PDLA), provides …
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Phase transitions of poly (l-lactic acid) in bulk and in solution
Poly(L-lactic acid) (PLLA) has been subject to intensive research in recent years because of its biodegradability. Applications of PLLA, such as porous tissue engineering scaffolds and excipients for controlled release, have been developed in the biomedical and pharmaceutical fields. The crystal …
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Soy protein-poly (l-lactic acid) blend nanofibers for drug delivery of nardostachys jatamansi
… Biodegradable nanofibers were developed using Poly (L - lactic acid) and Soy protein for the delivery of an ayurvedic drug, Nardostachys jatamansi. A weighed quantity of powdered drug - Nardostachys Jatamansi was subjected to Soxhlet extraction using water and ethanol in equal quantities. …
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Controlling the alignment and degradation of 3D printed poly-L-lactic acid for redesigned coronary stents
… commercially successful material for this is polylactic acid (PLA), although, numerous challenges remain before the stent’s wider implantation. As a material, PLA is widely used within fused filament fabrication (FFF) 3D printing. FFF could be a viable technique for manufacturing …
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A combined experimental and computational framework to optimise processing and design of poly(L-lactic acid) bioresorbable stents
… immunological responses. Bioresorbable polymer stents offer an attractive solution, providing a temporary scaffold that resorbs once the artery heals. However, polymeric stents are mechanically inferior to their metallic counterparts, requiring thicker struts to provide equivalent radial …
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Poly(L-Lactic Acid) Langmuir Monolayers at the Air/Water Interface and Langmuir-Blodgett Films on Solid Substrates: Phase Behavior, Surface Morphology, and Crystallinity
… morphology and degree of crystallinity of poly(L-lactic acid) (PLLA) substrates have recently attracted considerable attention because of their applications in cell adhesion, tissue engineering, and drug delivery. Several techniques have been used to fabricate PLLA substrates, some of which …
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Thermal and morphological analysis of collagen-plla electrospun blends
Electrospinning of bovine Type I collagen and Poly (L-lactic acid) produces blended nanofiber scaffolds that may have application in tissue engineering, wound dressing and drug delivery. The goal of this research work was to produce and characterize blended nanofibers of a protein, collagen, and a …
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Magnetic targeted drug delivery system in gene therapy
… efficiency and low cytotoxicity. PLLA(poly(L lactic acid)) can be biodegradable and has high biocompatibility. PLLA is already used in functional biomedical materials, including functional gene vectors. This thesis covers the synthesis and characterization of superparamagnetic iron …
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Polymer structure and property studies in elongational rheology, spherulite deformation, and biaxial strain induced crystallization
… rheological investigation of well characterized polyethylene samples. Elongational stress growth measurements as well as dynamic shear experiments demonstrated that the rheological response of molten polyethylene was sensitive to both molecular weight distribution and shear modification. The …
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Fabrication of hydroxyapatite-biodegradable polymer scaffolds by electrospinning for potential bone tissue application
… potential of combining hydroxyapatite (HA) and polymers to form synthetic composite materials used for bone tissue engineering applications. In this study, ceramic-biodegradable polymer composites are fabricated by electrospinning method. The biodegradable polymers used are poly(L-lactic acid) …
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Mechanical properties of bio-absorbable materials
… for orthopedic appliances. The study focuses on Poly(l-lactic acid) (PLLA), Polyglycolic acid (PGA), Poly-e-caprolactone (PCL), matrices with Carbon fibers (AS4), Nylon fibers and PLLA fibers. Fiber coating effects have also been investigated, with compliant polymers (1%, 50% and 100% of matrix …
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Controlled drug release from oriented biodegradable polymers
… for controlling drug release from biodegradable polymers. The effect of various degrees of polymer orientation was studied in oriented Poly (L-lactic acid) (PLA) films containing curcumin and theophylline as model drugs. Additionally, direction specific drug release was studied from oriented PLA …
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AMPHOTERIC POLYAMIDOAMINES AS FUNCTIONAL SPECIALTY POLYMERS
… the synthesis and characterization of amphoteric polyamidoamines in both linear and cross-linked forms. The study is organized into two main thematic lines, each comprising multiple projects. The first one was to evaluate the potential environmental impact of amphoteric water-soluble PAAs, which …
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Characterization and Fabrication of Scaffold Materials for Tissue Engineering
… plays an important role in cell function. Poly(ester urea) (PEU) is regarded as a promising biodegradable scaffold material for tissue engineering. In this study, physical and mechanical properties including Young’s modulus, storage modulus, water uptake profile, and degradation rate for …
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The synthesis of novel biodegradable polyesters and copolyesters from anhydrosulfites
… with the synthesis and the ring-opening polymerisation of anhydrosulfites (1,3,2-dioxa-thiolan-4-one-2-oxides), and secondly with the copolymerisation of anhydrosulfites with -caprolactone. The polyesters and copolyesters synthesised are of considerable interest in medical applications …
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Investigation of electrospun fibrous scaffolds, locally delivered anti-inflammatory drugs, and neural stem cells for promoting nerve regeneration
… In this study, electrospun fibers composed of poly(L-lactic acid) (PLLA) and polycaprolactone (PCL) were prepared with and without the steroid anti-inflammatory drug, dexamethasone, encapsulated. Histological analysis of harvested subcutaneous implants demonstrated the PLLA fibers encapsulating …
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Development and characterization of advanced nitric oxide-delivering polymeric systems against cardiovascular complications
… calcification. Local delivery of NO through Poly(L-Lactic acid) (PLLA) matrix systems incorporated with poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing DETA NONOate were formulated for the prevention of valve complications. Similarly, S-nitrosoglutathione incorporated …
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Production and characterization of composite nano/micro sized particles by rapid expansion of supercritical solutions (ress) co-precipitation
… 3, 5-trinitro-1, 3, 5-triazine (RDX) and polymer binders were produced by co-precipitation using rapid expansion of supercritical solutions (RESS). The binders used in this study are poly (vinylidene fluoride-co-hexafluoropropylene) (VDF-HFP22), polystyrene (PS) and 7-amino-4-methyl …
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A resorbable polymeric microreservoir device for controlled release drug delivery
… test, and characterize a biodegradable polymeric microreservoir device that is capable of delivering multiple pulses of drugs in a reproducible manner. This polymeric microreservoir device contains an array of reservoirs that are each covered by a thin membrane of a degradable polymer. …
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A three-dimensional in vitro tumor model representative of the in vivo tumor microenvironment
… including bacterial cellulose, electrospun polycaprolactone/collagen I, and highly porous electrospun poly(L-lactic acid). However, cancer cells cultured on these scaffolds demonstrated poor adhesion, sufficient adhesion with poor infiltration, and increased but still inadequate …
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