Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Poly(A) Site"”.
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Transcriptional elongation defects enhance upstream poly (A) site utilization and SPT5 affects mRNA degradation through its physical and functional interaction with CCR4 -NOT complex
… several genes, each of which contain internal poly (A) sites, whose full-length mRNA formation is reduced by mutations in RNA polymerase II subunit RPB2, elongation factor SPT5, or TFIIS. RPB2 and SPT5 defects also promoted the utilization of upstream poly (A) sites for genes that contain …
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SAM Homeostasis Is Regulated by CFIm-Mediated Splicing of MAT2A
… cleavage factor Im (CFIm) complex that regulates poly(A) site selection, but we show it promotes MAT2A splicing independent of poly(A) site selection. CFIm25-mediated MAT2A splicing induction requires the RS domains of its binding partners, CFIm68 and CFIm59 as well as binding sites in the …
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Mammalian gene regulation through the 3' UTR
… of motifs, microRNA (miRNA) complementary sites and cleavage and polyadenylation (poly(A)) signals, and provide evidence that specific sequence contextual features are important for their recognition. MiRNAs are 22 nt, non-coding RNAs that function as post-transcriptional gene regulators in …
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A bioinformatics framework for RNA structure mining, motif discovery and polyadenylation analysis
… (genomes of various mammals, viruses and parasites) and our experimental results show that this approach is capable of detecting functionally important regions. As an application of RADAR, a systematic data mining approach was developed, termed GLEAN-UTR, to identify small stem loop RNA …
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Deconvoluting Cell-Type Specific 3'UTR Isoform Expression in the Adult and Developing Cerebellum
<p>Alternative polyadenylation has been implicated in the regulation of mRNA translation and stability, as well as mRNA and protein localization. However, it is unclear to what extent alternative polyadenylation regulates these processes uniquely in specific cell types. Using a newly developed …
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Prediction of mRNA polyadenylation sites in the human genome and Mathematical modeling of alternative polyadenylation
Messenger RNA (mRNA) polyadenylation plays many important roles in the cell, such as transcription termination, mRNA stability and transportation, and mRNA translation in eukaryotic cells. A large number of human and mouse genes have multiple polyadenylation sites (referred to as poly(A) sites) …
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Die massive Expression von NF-ATc/A ist eine Eigenschaft Antigen-erfahrener Th1- und Th2-Zellen und trägt zur selektiven Induktion des IL-4 Promotors in Th2-Zellen bei
… Dies wird infolge alternativer Spleiss- und Polyadenylierungsvorgänge durch die Benutzung einer proximalen, gering-affinen poly A-"site", pA1, ermöglicht, die nur bei hohen Konzentrationen von poly A-Faktoren – wie sie in Effektor-T-Zellen vorliegen – erkannt wird und in naiven T-Zellen …
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cDNA Cloning and Gene Characterization of Large and Small Subunits of Ribonucleotide Reductase in Soybean
… triphosphates, substrates for DNA polymerase. By controlling the supply and balance of deoxyribonucleoside diphosphates, RNR regulates DNA synthesis. RNR in E. coli and in animals consists of two identical large and two identical small subunits. Until recently, little was known …
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Promoter directionality is controlled by U1 snRNP and polyadenylation signals in mouse embryonic stem cells
RNA polymerase II (RNAPII) transcription is a tightly regulated process controlling cell type and state. Advancements in our understanding of how transcription is regulated will provide insight into the mechanisms controlling cell identity, cellular differentiation, and its misregulation in …