Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Point-of-care testing"”.
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Increasing point of care testing for glycated hemoglobin A1c levels in a family health clinic
… goal for a nonpregnant healthy adult is a value of 7% to lower the risk of DM-related complications (American Diabetes Association [ADA], 2021). Because a goal of 7% may not be feasible in many cases due to other variables, each person with diabetes should have an individualized goal and …
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A “Zero-Background” Multiplexed, Point-Of-Care Testing Platform for Disease Diagnosis, Management, and Surveillance
… or antigens, to detect and quantify a biomarker of interest from a clinical specimen based on highly sensitive and specific binding interactions. While laboratory-based assays, such as enzyme-linked immunosorbent assay (ELISA), are the workhorses of clinical laboratories, they have several …
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Evolution-dependent SARS-CoV-2 vaccination success determined by neutralizing antibodies and reliability of point-of-care testing
… and isolated an early Wuhan-like type (wt) of SARS-CoV-2 and the variants of concern Alpha, Delta, Omicron BA.1, and Omicron BA.2. Moreover, we established a Vero cell-based virus neutralization test to validate various diagnostic systems and to estimate vaccination success. Since RT-qPCR …
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Rapid point of care testing for sexually transmitted diseases and bacterial vaginosis: cost estimation and budget impact analysis
… in women poses a challenge towards the control of HIV/AIDS, more so in asymptomatic cases. Diagnosis of asymptomatic women using a genital inflammation screening tool, the cytokine biomarker rapid test, reduces the cases of untreated women. However, as a newly developed screening tool, there are …
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Petechiae in Children (PiC) study: evaluating potential clinical decision rules for the management of feverish children with non-blanching rashes, including the role of point of care testing for Procalcitonin & Neisseria meningitidis DNA
Background<br/>The aim of this prospective cohort study was to report the performance of existing clinical practice guidelines (CPG) for diagnosis of invasive meningococcal disease (MD) in children presenting with fever and non-blanching rash in the UK.<br/><br/>Methods<br/>Data were collected …
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Microfluidic and electronic detection of protein biomarkers
Proteins are essential components of our bodies and play critical roles in biological processes. Quantifying protein levels can help characterize these biological processes and detect malfunctions. Thus, protein testing is widely utilized in clinical diagnostics. The current workflow for protein …
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Development of spectroscopic smartphone biosensors for point-of-care applications
This dissertation explores the combination of two emergent areas within contemporary biosensing, smartphone based spectroscopy and photonic crystal enhanced microscopy, and how these technologies can be combined to produce a fundamentally novel point-of-care testing paradigm: a portable device …
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An Optical Aptamer-Based Carbon Nanosensor for Cortisol Detection
… physiological homeostasis during periods of physical or psychological stress. Consequently, it is critical to monitor levels of this hormone to understand different vital processes it can impact. This work presents the development of an optical aptamer-based carbon nanosensor for the …
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A spectroscopic smartphone biosensor for use in point-of-care diagnostic applications
This thesis serves to introduce a new point-of-care testing device capable of providing spectrometric data for solid and liquid phase samples. A custom cradle was developed to maintain optical alignment allowing for the diffraction, and therefore spectrometric analysis, of light transmitted either …
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POCT Testing and Importance of Operator Lock-out
<p>Point-of-Care Testing (POCT) is usually performed at the patient’s bedside by healthcare providers other than laboratory- trained professionals. Rapid growth of POCT is supported by numerous factors which include healthcare provider efficiency, improving diagnostic insight and better patient …
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Lens Fabrication by Accelerated Phase-Change for Mobile Multimodal Microscopic Imaging
Smartphones have become a ubiquitous form of personal computing that incorporate powerful imaging sensors, computational processing power, mobility, power, and networking in one portable package. By incorporating an add-on lens to a smartphone camera, microscopic imaging can be made possible. We …
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Portable blood plasma separation for point of care diagnostics
Point of care testing is expanding the healthcare field towards personalized and early-detection medicine. Microfluidic platforms present an opportunity for low cost, portable diagnostic sensors through manipulation of small volumes of fluids on isolated, compact devices. One of the challenges of …
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A Rapid and Power-Efficient Laser-Induced Graphene Micro-Thermocycler for DNA Polymerase Chain Reaction
By amplifying millions or billions of copies of a DNA’s specific segment, polymerase chain reaction (PCR) has a wide range of applications in DNA cloning, forensics, medical, and infectious disease detection. As a result, the technology is becoming more and more widespread as the COVID-19 pandemic …
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Cell-free synthetic biology for affordable, on-demand diagnostics
Detection of biomarkers, such as nucleic acids, performs critical roles in managing infectious disease outbreaks, point-of-care testing, and public health monitoring. However, many diseases and public health problems suffer from a lack of affordable, portable tests that can be used to sensitively …
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The Prediabetes Detection and Physical Activity Intervention Delivery (PRE-PAID) Project
… T2D. Given the potential for alleviating health care expenditures through the prevention or delay of T2D, targeting individuals with prediabetes using physical activity intervention is a critical research question. The aim of this project was to; i) identify persons with prediabetes and thus at …
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Antibiotic Stewardship Program Development in a Rural Urgent Care Clinic
Problem: The misuse and overuse of antibiotics are critical factors leading to antimicrobial resistance (AMR) and infections becoming harder to treat. Most antibiotics are prescribed in outpatient settings for upper respiratory infections (URIs), yet these infections are commonly caused by viruses …
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Developing a microfluidic-microwave platform for real-time, non-invasive and sensitive monitoring of pathogens and antibiotic susceptibility testing
Microfluidics and microelectromechanical systems (MEMS) are areas of studies that have become highly valued for their point-of-care (POC) and high-throughput potential, particularly in healthcare and biomedical applications. However, lab-on-a-chip devices often require supplementary equipment to …
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Affordable technologies for point-of-care diagnostics
Affordable, point-of-care diagnostics are needed for disease monitoring in low- resource settings (LRS). Gold-standard laboratory tests require expensive benchtop equipment, which limits their widespread use. In this work, I developed low-cost technologies for the transduction of two independent …
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