Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"Point-of-care diagnostics"”.
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Affordable technologies for point-of-care diagnostics
Affordable, point-of-care diagnostics are needed for disease monitoring in low- resource settings (LRS). Gold-standard laboratory tests require expensive benchtop equipment, which limits their widespread use. In this work, I developed low-cost technologies for the transduction of two independent …
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Mobile platform based point-of-care diagnostics
Optical imaging of biomolecules and chemicals has been instrumental in detecting the target of interest for many diverse fields such as biomedicine, nanotechnology, and chemical science. With the recent advances of optical measurement for reflection, absorbance, and fluorescence, highly sensitive …
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Engineering scFv Antibodies for Point-of-Care Diagnostics
… Kidney Injury is a common condition seen in 30% of neonates in the ICU and results in poor healthcare outcomes. The rapid assessment of the glomerular filtration rate (GFR), a metric of kidney function, can guide the dosing of renally-cleared lifesaving antibiotics, thereby preventing organ …
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Pump-free magnetophoresis for improved point-of-care diagnostics
Infectious diseases are one of the largest health burdens for low-income countries and claim millions of lives every year. The loss of life in low-income countries is largely due to the lack of access to preventative healthcare and appropriate diagnostic testing. Several health agencies have …
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Immunological and Molecular Techniques for Point-of-Care Diagnostics
The development of technologies that enable early and accurate diagnosis is critical to the management of infectious diseases, especially with highly transmissible pathogens or in cases where the early administration of the right antibiotics could be life-saving. Demonstrating the presence of the …
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Portable blood plasma separation for point of care diagnostics
Point of care testing is expanding the healthcare field towards personalized and early-detection medicine. Microfluidic platforms present an opportunity for low cost, portable diagnostic sensors through manipulation of small volumes of fluids on isolated, compact devices. One of the challenges of …
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FIELD-PROGRAMMABLE MICROFLUIDIC TEST PLATFORM FOR POINT-OF-CARE DIAGNOSTICS
… has demonstrated their great potential in microfluidics; however, further work is needed to integrate EWOD technology into a system deployable for point-of-care (POC) diagnostics. This research is aimed at providing enabling technologies that foster a development path of EWOD devices using a …
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Lithographically Fabricated Micro-Reflectors for Sensitive Point of Care Diagnostics
Timely diagnosis and treatment of infectious diseases calls for highly sensitive diagnostic assays. Traditional diagnostic methods include microscopy, polymerase chain reaction (PCR), immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). Many of these diagnostic methods, however, …
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Application of polymerization-based amplification in point-of-care diagnostics
… on enzymatic reactions and gold nanoparticles often produce results that must be read within a specified time interval to ensure their validity. In many instances, a user has to wait several minutes for the color to develop. Moreover, the result can be interpreted incorrectly because of low …
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The development of novel electroanalytical interfaces for point of care diagnostics
… including roles within the pathogenesis of a variety of clinical conditions. Independent analysis of these species is problematic and analytical difficulties relating to instrumental selectivity and sensitivity need to be overcome. This thesis describes the work carried out on the …
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Development of an optical cavity-based biosensor for point-of-care diagnostics.
… using a differential detection method towards point-of-care (POC) diagnostic applications. The optical cavity consisting of two partially reflective surfaces with a small gap was designed and optimized using a simulation tool, FIMMWAVE/FIMMPROP. The optical cavity samples were fabricated in the …
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Whispering photons : on-chip biophotonic integrated circuits for point-of-care diagnostics
The pressure of increasing service demands and improving turnaround times of results in healthcare industry require the development of more rapid, point-of-care and personalized diagnostic tools. Light is ubiquitous in biology and offers various elegant solutions for diagnostic, therapies and …
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Evaluating the impact of point-of-care diagnostics on disease outbreaks in low resource settings
… early intervention measures and minimize risk of disease transmission. Recent outbreaks in low-resource settings have highlighted challenges with traditional laboratory-based diagnostic approaches including a dependence on supporting infrastructure and highly trained users. Limitations of …
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A portable, smartphone-linked, and miniaturized photonic resonator absorption microscope (PRAM MINI) for point-of-care diagnostics
… published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Decision analysis of novel point-of-care diagnostics for Pediatric Pneumonia : implementation in Developing countries with tiered healthcare systems
… Pneumonia (PNA) is the single leading cause of death in children under five, accounting for 19% of all childhood deaths worldwide. Due to severe resource constraints on healthcare, the global burden of the disease in children is disproportionately shared by developing countries. In …
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Analysis of value creation and value capture in microfluidics market
Advances in microfluidics in the last two decade have created a tremendous technological value which is shaping genomics; drug discovery; proteomics; and point-of-care diagnostics. The positive impact has resulted in faster analysis time, increased throughput and reduced cost amongst other …
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Elastin-like polypeptide (ELP) tags for self-assembly and high-throughput processing of functional protein materials
… diverse recognition and catalytic capabilities of globular proteins makes these biomolecules promising candidates in a broad array of applications, including industrial production of commodity chemicals, point-of-care diagnostics, and therapeutics. Self-assembly of globular protein-polymer …
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Rational hydrogel design for point-of-care bioassays
… and monitoring so that patients can get the care they need. This is particularly evident in the developing world, where many people live far from diagnostic laboratories. Point-of-care diagnostics are tests that can be run in doctor's offices, clinics, and in patient homes. These tests must …
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Biomedical applications of holographic microscopy
… with aggressive cancers is a major healthcare challenge in resource-limited settings such as sub-Saharan Africa. Holographic imaging techniques have been shown to perform diagnostic screening at low cost in order to meet this clinical need, however the computational and logistical …
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Rapid & controlled manufacturing of microfluidic devices using hot embossing
Microfluidics are becoming commonplace in research and medicine, particularly in point-of-care diagnostics and drug development. Many manufacturing methods exist for such devices, but initial setup can be costly and slow, hindering the ability to quickly iterate on designs. Hot embossing has …
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