Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Point-of-care (POC)"”.
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Development of Novel Biosensor Platforms for Point-Of-Care (POC) Diagnostics
This thesis presents contributions to the field of point-of-care (POC) testing through the identification of novel biosensing technologies for the detection of stress-related proteins and monitoring of DNA amplification procedures in real-time. The studies presented herein successfully demonstrated …
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The development and application of point-of-care pathology testing (POCT) models for the early detection and management of diabetes and renal disease in indigenous medical services.
… question examined in this thesis was: Could POCT ( point-of-care pathology testing) models that were analytically sound and clinically and culturally effective be established in Australian Indigenous medical services for the prevention and management of diabetes and renal disease? The …
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Development of thermostable affinity reagents for low-cost, paper-based medical diagnostics
The timely diagnosis and treatment of disease in resource-constrained settings requires the development of robust point-of-care (POC) diagnostics, which provide accurate results and can be employed by users with minimal medical training and limited access to basic infrastructure. One of the most …
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The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools
Lack of point-of-care (PoC) diagnostic tools for TB hinders control of the disease, particularly in resource-limited, high HIV and TB prevalence countries. Therefore, there is a need for simple, rapid, accurate, and affordable PoC diagnostics to detect active TB early enough for opportune …
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Development of Innovative Technologies for DNA Extraction and Detection
… Questi tipi di tecnologie sono chiamati Point-of-Care (PoC) e potrebbero creare le condizioni per un'analisi clinica più efficiente, introducendo una serie di vantaggi: Procedure rapide ed economiche per la preparazione e l'analisi di campioni biologici Diagnosi veloce Identificazione e …
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Signal Processing Techniques Applied to Biomedical Diagnostics
… diagnostic tests that can be administered at the point of care (POC). Developing such miniaturized, portable, and low-cost systems requires innovative approaches in both assay and device design. In this thesis, we construct a novel phase-sensitive "lock-in" amplifier (LIA) based on the Fast …
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Interferon-γ aptamers for the diagnosis of extra-pulmonary tuberculosis
… is a major global health problem. About 15-20% of the global population who are HIV negative have extra-pulmonary TB (EPTB) such as pleural TB. This increases to 50-70% in HIV positive people. The diagnosis of EPTB is challenging because of the low bacillary burden. Interferon gamma (IFN-γ) has …
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Operational Innovations to Improve Malawi’s HIV Sample Transportation Network
The African nation of Malawi, like other sub-Saharan countries, provides diagnostic testing to its citizens through a centralized laboratory network. Diagnostic samples are collected from patients at remote, point-of-care health facilities and diagnostic tests are performed at centralized …
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Development and Characterization of Reagent Pencils for Microfluidic Paper Based Analytical Devices
<p>Microfluidic paper based analytical devices (microPADs) are a novel platform for point of care (POC) diagnostics. Limitations of reagent shelf life have been overcome with the introduction of reagent pencils as a method for solid-based reagent deposition. While useful, little work has been …
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DEVELOPMENT OF A RAPID DIAGNOSTIC ASSAY FOR THE COLORIMETRIC DETECTION OF BACTERIAL AND VIRAL PATHOGENS USING LOOP-MEDIATED ISOTHERMAL AMPLIFICATION COUPLED WITH A PEPTIDE NUCLEIC ACID AND GOLD NANOPARTICLE REPORTER SYSTEM
<p>Detection of pathogenic agents remains pivotal to the control and prevention of infectious disease. While diagnostic methods continue to break barriers, the need for accurate, sensitive, and rapid methods persists. Current methods for pathogen detection, including culture, immunochemical, or …
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Desenvolvimento de moléculas aplicadas no diagnóstico sorológico e molecular de doenças bovinas
… de baixo custo, otimizados para uma detecção Point-of-care (POC). Palavras-chave: Phage-display. Aptâmero. Proteína quimérica. Triagem computacional
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Development of gold nanoparticles based lateral flow assay for detection of food and water-borne pathogens
Food and water are two of the necessities required for survival. With increasing global population, urbanization, and climate change, to name a few, the strain on these two precious resources puts pressure on health as well as the economic sector. Microbial contamination of food and water can lead …
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Different Methodologies to Characterize and Diagnose Sickle Cell Disease in Both Developed and Developing Nations
… disease causes reduced oxygen carrying capacity of RBC resulting in painful crisis, hemolytic anemia, and infection susceptibility. SCD affects around 100,000 individuals in USA alone and 14 million people globally. SCD affected individuals have high mortality rates. Early detection and constant …
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Graphical and Bayesian Analysis of Unbalanced Patient Management Data
… at which blood clots. Healthy people have an INR of about one. Some people are at greater risk of blood clots and their physician prescribes a target INR range, generally 2-3. The farther a patient is above or below their prescribed range, the more dangerous their situation. A variety of …
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Ultrasensitive Biodetection based on Plasmonically-active Materials
A broad range of biomarkers continue to emerge as potentially important parameters for early detection of many pathological conditions.1 A disease biomarker (e.g. protein, a fragment of a pro-tein, DNA/RNA, or metabolites) is a ‘molecular signature’ of the physiological state of patient at specific …
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Increased sensitivity for lateral flow immunoassays through signal amplification methods
… LFIAs, and rapid diagnostic tests, RDTs) are one of the general approaches for detection of disease targets (e.g. nucleoprotein of the influenza virus). However, the use of these LFTs is limited because of their well-recognized lack of sensitivity. To improve the sensitivity of LFTs for influenza …
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FIELD-PROGRAMMABLE MICROFLUIDIC TEST PLATFORM FOR POINT-OF-CARE DIAGNOSTICS
… has demonstrated their great potential in microfluidics; however, further work is needed to integrate EWOD technology into a system deployable for point-of-care (POC) diagnostics. This research is aimed at providing enabling technologies that foster a development path of EWOD devices using a …
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Acoustic resonators with integrated microfluidic channels for ultra-high Q-factor: a new paradigm for in-liquid gravimetric detection
<p>Biosensing is a critical area of research that involves detecting and measuring biological molecules. Among the various types of biosensors, acoustic biosensors are attractive for their simplicity, robustness, and low cost, particularly in point-of-care (POC) applications. However, the quality …
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Spray coated bentonite/MWCNT composite enzymatic biosensor for uric acid detection
Biosensors are widely used in healthcare and diagnostics, offering rapid and reliable detection of biological analytes. This study presents the development of an enzymatic uric acid (UA) biosensor based on a nanocomposite of bentonite (BT) and multi-walled carbon nanotubes (MWCNTs) fabricated via …
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Understanding protease-mediated host-pathogen interactions in <i style="">Proteus mirabilis</i>
… infections (CAUTIs), which account for 80 % of all nosocomial infections. ZapA is an important virulence factor that contributes to the evasion of <i>P. mirabilis</i> from innate immunity via the hydrolysis of host structural proteins such as cytoskeletal and extracellular matrix components, …
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