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Showing 1 to 8 of 8 for “"Podophyllotoxin"”.

  1. The chemistry of podophyllotoxin

    Price, Edward Hector1949

    maryland Repository record

  2. Synthesis of labelled precursors of podophyllotoxin

    Pullockaran, Anie JoseVirginia Tech1989

    Podophyllotoxin is an aryltetralin lignan and anticancer agent produced by the <i>Podophyllum</i> and some other species and is extracted from Podophyllin in up to 30 percent yield. Little definitive information is available on the biosynthetic pathways to podophyllotoxin. Administering various …

    vt Repository record

  3. Study of podophyllotoxin biosynthesis in Podophyllum species

    Baur, Wendy L.Virginia Tech1990

    … afford the various Iignan skeleton structures. Podophyllotoxin is a tetrahydronaphthalene lignan found in Podophyllum species, and its derivative etoposide is widely used medicinally for skin cancer and venereal warts (Condyloma acuminatum). In this investigation, the biogenetic pathway to …

    vt Repository record

  4. I. Synthesis of Analogs of Podophyllotoxin. II. Synthesis and Properties of p-Quinone Diimides

    Heumann, Karl FredrichUniversity of Illinois at Urbana-Champaign1951

    uiuc Repository record

  5. Studies on the biosynthesis of podophyllotoxin:synthesis of labelled yatein and matairesinol, two potential precursors of podophyllotoxin

    Neidigh, Kurt AlanVirginia Tech1992

    Podophyllotoxin, a naturally occurring lignan isolated from several species of Podophyllum, is used as a precursor to the clinical chemotherapeutic agents teniposide and etoposide. The biosynthesis of podophyllotoxin is not fully understood, but its optical activity, like that of most lignans, is …

    vt Repository record

  6. Studies on biological activities of Scottish plants.

    Kumarasamy, YashodharanRobert Gordon University2006

    … = 1.18 x 10-6 muM) when compared to the control podophyllotoxin (LD50 = 6.5 x 10-6 muM). The two lignans, arctiin and malairesinol and the control podophyllotoxin were tested in in both hypoxic and normoxic conditions, using 3 cell lines CaCo2, MCF -7, and MDA 468 and it was observed that they …

    rgu Repository record

  7. Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension

    Sharmin, NahidUniversity of Bradford2018

    … drugs (doxorubicin, taxol, digitoxin and podophyllotoxin) inhibit the excessive proliferation and induce apoptosis in BMPR2 mutant PASMCs by modulating the BMP and TGF-β pathways. Moreover, established drug PTC124 has also been tested but has failed to promote translational readthrough. I …

    bradford Repository record

  8. An investigation into the antineoplastic potential of Bridelia Micrantha Constituents

    University of Pretoria2007

    … lignan glycosides (structurally related to podophyllotoxin), served as motivation for undertaking this study. The in vitro antineoplastic potential of several different solvent extracts of B. micrantha (bark) has been investigated. Five out of the six primary extracts displayed impressive …

    pretoria Repository record