Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Podocytes"”.
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Regulation of Fluid-phase Uptake in Podocytes by Albumin-associated Lipids
<p>I. Podocytes are specialized epithelial cells in the kidney glomerulus that play important structural and functional roles in maintaining the filtration barrier. In nephrotic syndrome, a major breakdown of the kidney filtration barrier associated with proteinuria, hyperlipidemia, and edema, …
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An Account of Chemical and Mechanical Regulation of TRPC6 Channels in Podocytes
Podocytes play a dynamic role in regulating glomerular filtration. The focus here is on the regulatory mechanisms of podocyte expressed transient receptor potential 6 (TRPC6) channels, an ion channel implicated in certain forms of proteinuric kidney disease. TRPC6 channels are polymodal and can be …
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Characterization of signaling pathways regulating nephrin endocytosis in kidney podocytes: novel roles for Nck and ShcA adaptor proteins
Kidney podocytes maintain blood filtration selectivity through a network of actin-based projections termed foot processes. The slit diaphragm is a molecular barrier that lies laterally between foot processes and acts as a discerning filtration pore. Nephrin is a key component of this barrier and …
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Significance of α-Lipoic acid on cell viability and nephrin in human podocytes under normal and high glucose conditions
Introduction: Human podocytes (hPC) play a pivotal role in maintaining kidney and glomerular function, while chronic kidney disease such as diabetic nephropathy has been characterized by loss or dysfunction of hPC. Nephrin is an important protein in hPCs and was found to maintain integrity and …
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Ruolo delle cellule staminali mesenchimali in modelli cellulari e animali di nefropatia
… Methods. We studied the effects of MSC on podocytes ‘in vitro’ and ‘in vivo’ utilizing adriamycin (ADR) as a model of renal toxicity. The ‘in vivo’ experimental approach was carried out in male Sprague Dawley rats (overall 60 animals) treated with different ADR schemes to induce acute and …
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alpha-Actinin-4 and the podocyte: Implications for focal segmental glomerulosclerosis
… damage to glomerular epithelial cells called podocytes, a key cell type involved in glomerular filtration. Mutations in the ACTN4 gene, encoding an actin-crosslinking protein, are causative of late-onset familial FSGS in humans. We have developed a mouse model of FSGS by expressing a …
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A Stem Cell-Based Strategy for Modeling Human Kidney Disease and Discovering Novel Therapeutics
… involve irreversible damage to kidney glomerular podocytes - the specialized epithelial cells that encase glomerular capillaries and regulate the removal of toxins and waste from blood. Therefore, the goal of this research proposal was to develop a novel strategy to protect or promote repair of …
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Molecular Responses to Desialylation in a Rat Model of Induced Glomerulopathy
… insight into specific molecular responses of podocytes to injury, in addition to demonstrating the versatility of this animal model for descriptive and mechanistic studies regarding podocyte sialobiology.
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Podocyte Melanocortin 1 Receptor Mediated Signaling
… activates a number of beneficial effects in podocytes and stabilizes the actin cytoskeleton. To study these mechanisms, we performed experiments with MC1R selective agonists in the in vivo models of nephrotic syndrome; PHN and adriamycin nephropathy (AN). MC1R stimulation had ameliorating …
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A Non-Canonical Function for NLRP3 and AIM2 in Kidney Diseases
… Interestingly, AIM2 was detected primarily in podocytes in the glomerulus and distal tubules at a low level. In a mouse model of nephrotoxic serum (NTS)-mediated anti-GBM, Aim2-/- mice displayed increased glomerular cellular crescent (multilayered accumulation of activated parietal cells) …
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Indagini strutturali e quantitative durante lo sviluppo del rene mediante l’utilizzo di elaborazione immagini
… fetuses. Moreover, the presence of podocytes in urinary space, and of clusters of mesangial cells at the periphery of the glomerulus, was observed. An average podocyte number of 2494 ± 317 and 1546 ± 372 was observed in normal fetuses and beta-thalassemic fetuses (P=0.0082) …
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Dynamic viscoelasticity of actin networks cross-linked with wild-type and mutant [alpha]-actinin-4
… for the structural and functional integrity of podocytes; deficiency or alteration of this protein due to mutations disturbs the cytoskeleton and results in kidney disease. This thesis presents rheological studies of in vitro actin networks cross-linked with wild-type and mutant a-actinin-4, …
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Modelling Human Glomerulosclerosis in vitro
… composed of glomerular endothelial cells (GECs), podocytes (PODs) and mesangial cells (MCs), and dysregulation in the interaction between these cell types results in glomerulosclerosis. This is characterised by excessive extracellular matrix deposition and cell dysfunction leading to …
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Investigations on the Effects of Palmitate on Neuronal Cells
… with increased apoptosis in hepatocytes, podocytes, myocytes, and pancreatic islet cells. However, the effects of FAAs on neuronal cell function are not well characterized. In this study, mouse neuroblastoma cells from the Neuro-2a (N2a) cell line were treated with either bovine serum …
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Single nephron structure and function, and renal effects of catecholamines in the dogfish, Scyliorhinus canicula
… epithelium of the glomerulus was composed of podocytes, primary processes and interdigitating pedicels. Morphological variations were common, with areas of flattening and broadening of these structures. 3. The nephron was found to be composed of Bowman's capsule, neck segment, first, second …
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The Role of Von Hippel-Lindau Protein in the Glomerulus
… Cxcr4, whereas overexpression of Cxcr4 alone in podocytes of transgenic mice is sufficient to cause glomerular disease. Despite the development of glomerular disease in mice that overexpress Cxcr4, their disease was milder and lacked features of full-blown RPGN. The Vhlh gene encodes VHL protein …
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Adaptive fabrication of biofunctional decellularized extracellular matrix niche towards complex engineered tissues
… of human glomerulus endothelial cells and podocytes was performed on this device, to simulate the blood-to-urine interface in vitro. Good cell attachment and viability were demonstrated, and specific cell differentiation and fibronectin secretion were observed. This dECM-laden protein …
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Phosphodiesterase 1 (PDE1) at the Crossroads of Calcium and Cyclic Nucleotide Signaling in Diabetic Nephropathy
… muscle cells, renal tubular epithelial cells, podocytes, and mesangial cells. We used highly potent and selective PDE1 inhibitor LY1 to explore systemic hemodynamic and local renal role of PDE1. LY1 reduced systolic and diastolic blood pressure in normotensive and spontaneously hypertensive …
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Dynamics of the glomerular filtration barrier - Physiological and pathophysiological aspects
… the cytoskeleton of endothelial cells and/or podocytes may be involved. In study IV, high or low doses of ANP induced an increase in glomerular permeability for Ficoll 50-80Å, reaching its maximum at 5 and 15 min. During ANP infusion (cf. congestive heart failure) there was a bimodal response, …
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