Global ETD Search
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Showing 1 to 20 of 24 for “"Pneumonitis"”.
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Improving The Accuracy of Radiation Pneumonitis Dose Response Models
… most prevalent thoracic toxicity is radiation pneumonitis. In order to determine a safe dose that can be delivered to the healthy lung, researchers have turned to mathematical models predicting the rate of radiation pneumonitis. However, these models rely on simple metrics based on the …
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Utilizing Computed to mography Image Features to Advance Prediction of Radiation Pneumonitis
… symptomatic lung toxicity, termed radiation pneumonitis (RP), still occurs. Identifying the individuals at risk of RP prior to or early during treatment offers tremendous potential to improve RT by providing the physician with information to assist in making clinical decisions that enhance …
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HP Turns 17: T helper 17 cell response during hypersensitivity pneumonitis (HP) and factors controlling it
<p>Hypersensitivity Pneumonitis (HP) is an interstitial lung disease caused by repeated inhalation of a wide range of environmental antigens. It is characterized by alveolitis, granuloma formation, and fibrosis. Since HP is a T cell-mediated disease, it is important to determine the type of T cell …
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The efficacy of prophylactic antibiotics in the management of pneumonitis following kerosene (paraffin) ingestion in children
Includes abstract. Includes bibliographical references.
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Protein Kinase D1 in Myeloid Cells Promotes Disease Progression and Severity in S. rectivirgula Induced Hypersensitivity Pneumonitis
Introduction: Hypersensitivity pneumonitis (HP) is an inflammation driven interstitial lung disease characterized by inflammation of the interstitium, bronchioles, and alveoli of the lung that leads to granuloma formation. Myeloid lineage immune cells play a critical role in the early and late …
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Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
<p>Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by repeated inhalation of environmental antigens. The disease is characterized by alveolitis and granuloma formation; however, some patients develop chronic HP (CHP), a restrictive lung disease characterized by fibrosis. …
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Ensemble Support Vector Machine Models of Radiation-Induced Lung Injury Risk
… inflammation of the lungs known as radiation pneumonitis: RP). In practice, modeling RP factors is difficult because existing data are under-sampled and imbalanced. Support vector machines: SVMs), a class of statistical learning methods that implicitly maps data into a higher dimensional …
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Exhalatkondensat bei Gesunden und thorakal bestrahlten Patienten
… birgt stets das Risiko der Entstehung einer Pneumonitis, deren frühe Diagnose wichtig ist. Mit der Exhalat-Kondensat-Methode gelingt es, die alveoläre Oberfläche wenig invasiv und beliebig oft wiederholbar untersuchen zu können. Methodik, Variabilität der Exhalatparameter bei Gesunden, …
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Soy Isoflavones Mediate Radioprotection Of Normal Lung Tissue By Modulating The Radiation-Induced Inflammatory Response
… as well as lung parenchyma, lead to clinical pneumonitis. Activated cells produce molecular mediators and growth factors that affect the proliferation and gene expression of lung fibroblasts. This process leads to increased collagen synthesis and deposition, eventually leading to the …
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A posztnatális CMV fertőzés rizikója és következményei koraszülött intenzív osztályon
… súlyos és változatos tüneteket (leggyakrabban pneumonitis) okozhat, sőt akár halálos kimenetellel is járhat a fertőzés. A diagnosztika PCR vizsgálattal történik, az anyatejből, valamint az újszülöttek nyál, vizelet vagy vérmintájából. A kezelés egyéni mérlegelés alapján történhet, azonban …
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Interstitial lung disease (ILD) in adult patients with autoimmune connective tissue disease (CTD) at Groote Schuur Hospital
… restarted after ILD diagnosis. No case of acute pneumonitis was documented. Pulmonary function tests and high-resolution computer tomography severity correlated poorly, with PFTs underestimating the severity. In the analysis comparing patients with and without UIP, RA diagnosis (OR 3.8, 95% CI …
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Mechanisms Regulating Pulmonary Sensitivity to Radiation
… countermeasure (MCM) for mitigating or treating pneumonitis/fibrosis following acute radiation exposure. Since it is neither ethical nor feasible to evaluate potential MCMs against radiation injury in the clinical setting, the FDA permits MCM licensure under an alternative drug development …
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Observations on the Pathogenesis of Canine Encephalitozoonosis
… nephritis, meningoencephalitis, hepatitis, and pneumonitis. A large component of the inflammatory infiltrate consisted of plasma cells and lymphocytes. In addition, hyperplasia of B-lymphocyte dependent regions of lymph nodes and erythrophagocytosis were consistently seen in infected dogs. …
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… multi-organ autoimmunity and died of autoimmune pneumonitis at age 11 years. His older brother also had type 1 diabetes and died of pneumonitis of undocumented etiology at age 3 years. Moreover, I had an opportunity to study another two siblings with inherited PD-L1 deficiency, both of whom had …
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A Preclinical Study of Radiation-Induced Lung to xicity When Irradiating In A Strong Magnetic Field
… used to assess the severity of radiation-induced pneumonitis.</p> <p>Cox regression showed that dose was a much higher predictor of survival than magnetic field strength. The presence of a transverse 1.5 T field during irradiation had little to no effect on survival for each of the dose groups. …
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The characteristics of intersitial lung disease patients attending Groote Schuur Hospital Respiratory clinic
… disease-ILD (CT-ILD) 26%. Hypersensitivity pneumonitis accounted for 5% of follow-up patients, and only 2 IPF patients were in follow-up. CTD-ILD was the most common diagnosis in new patients: 43% and 29% had sarcoidosis. Five new patients were diagnosed with IPF during the 6-month study …
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Early Versus Delayed Tracheostomy in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease
… 1.041- 2.523) (P=0.0326). The risk of aspiration pneumonitis was not statistically different between both groups (Odds ratio, 0.771; 95% CI, 0.588-1.01) (P=0.059). The hospital length of stay was significantly lower in the early group compared with a late group (Median, 19 vs 29; Odds ratio, …
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Mitomycin/Cisplatin oder Mitomycin/Vinorelbin und Erythropoetin als Therapie bei vorbehandelten Patienten mit Rezidiv eines NSCLC innerhalb des Bestrahlungsfeldes
… an einer Mitomycin-induzierten interstitiellen Pneumonitis. Die Hämoglobinkonzentration stabilisierte sich über 11g/dl. Zusammenfassend konnte gezeigt werden, dass eine klinische Studie in diesem anspruchsvollen Patientenkollektiv möglich ist und dass die Kombinationstherapie mit Mitomycin …
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Auswirkungen ionisierender Strahlung auf das Proliferationsverhalten humaner fetaler Lungenfibroblasten im Ko-Kultur-Modell
… eine Schädigung des Lungengewebes im Sinne einer Pneumonitis (bei ca. 7-20 % aller Patienten) oder einer Lungenfibrose (bei bis zu 39 % der Patienten nach mehreren Jahren) auftreten. Dabei haben die Fibroblasten als ortsständige Bindegewebszellen einen aktiveren Anteil, als lange Zeit angenommen. …
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Prognostication and disease monitoring in fibrotic interstitial lung disease
… fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (fHP), qCT is independently associated with transplant- and progression- free survival. In systemic autoimmune rheumatic disease related ILD, changes in qCT correlated with changes in pulmonary function testing (PFT) and ground glass …
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