Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Pneumonic plague"”.
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Molecular design of nanoparticle-based delivery vehicles for pneumonic plague
… degradable polymer-based adjuvant engineering, plague (<i>Yersinia pestis</i>) biology, and vaccines that confer protection against plague.</p> <p>Chapter 3 overviews the research objectives and the specific aims of this work.</p> <p>Chapter 4 describes the effect polymer chemistry has on uptake …
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Heterologous Prime-Boost strategies using live-attenuated and viral vector vaccines to combat pneumonic plague
… were evaluated for protective efficacy against pneumonic plague. A single immunization event giving both Ad5-YFV and LMA at once was also tested as a potential strategy for use during an outbreak when quick protective immunity is desired. While the Ad5-YFV vaccine harbors a fusion cassette of …
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Heterologous Prime-Boost strategies using live-attenuated and viral vector vaccines to combat pneumonic plague
… were evaluated for protective efficacy against pneumonic plague. A single immunization event giving both Ad5-YFV and LMA at once was also tested as a potential strategy for use during an outbreak when quick protective immunity is desired. While the Ad5-YFV vaccine harbors a fusion cassette of …
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Induction of Long-Term Immune Responses to Protect Mice against Pneumonic Plague: Development and Testing of Novel Live-Attenuated Mutants of Yersinia pestis CO92
… vaccine against the causative agent of the pneumonic plague, Yersinia pestis. Since both humoral and cell-mediated immunity are essential in providing protection against the plague, we developed three novel live-attenuated vaccine strains. These mutants were either deleted for genes encoding …
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Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease: Characterization of a potential live-attenuated vaccine candidate
… pestis, the causative agent of bubonic and pneumonic plague. Since both humoral- and cell- mediated immunity are essential in providing protection to the host against plague, we developed a live-attenuated vaccine strain by deleting Braun lipoprotein (lpp) and plasminogen-activating protease …
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Novel Virulence Factors in the Pathogenesis of Yersinia pestis Infection, the Causative Agent of Plague
… in Yersinia pestis, the causative agent of plague, and understanding their molecular mechanisms during an infection process are necessary in designing a better vaccine or to formulate an appropriate therapeutic intervention. By using a high-throughput, signature-tagged mutagenic approach, we …
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Dominant Suppression of Early Innate Immune Mechanisms by Yersinia pestis
Disease progression of primary pneumonic plague is biphasic, consisting of a pre-inflammatory and a pro-inflammatory phase. Most lung pathogens induce a measureable inflammatory response within a few hours of infection, but <italic>Yersinia pestis</italic> is strikingly different: the first 36 …
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New virulence mechanisms in Yersinia pestis, the plague (Black Death)-causing bacterium: A re-emerging and bioterror pathogen
… to become the causative agent of bubonic and pneumonic plague. Y. pestis is also a category A select agent based on its potential use as a biological weapon. Currently, there is no vaccine licensed in the United States for use against Y. pestis so continued research on understanding the …
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Combating Plague: Fighting a War on Two Fronts Through Vaccine Design and New Therapeutic Intervention
Assumed by many to be a disease of the past, plague continues to be a globally prevalent disease, with thousands of cases estimated to occur annually. With no FDA-approved vaccine and therapeutics limited to antibiotics, there is an imperative need to develop new prophylactics as well as …
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Prophylaxis of disease caused by bacterial pathogens of man
… there is a continuing public health problem from plague, especially in Africa, Asia and South America. In this thesis existing vaccines and antibiotics have been evaluated for the prevention and treatment of plague and found to have limitations. A number of approaches to the development of an …