Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Pneumolysin"”.
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Immunomodulatory effect of pneumolysin upon CD4 T cells
… involving the effect of the pneumococcal toxin, pneumolysin, upon the cells at the heart of the adaptive immune response; the CD4 T cell. I generated purified pneumolysin and a purified pneumolysin mutant called F433 to allow me to examine this potential effect. I found that pneumolysin inhibits …
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Cirrhosis-Induced Defects in Innate Puemonary Defenses Against Streptococcus Pneumoniae
… virulence factors, such as the toxin pneumolysin, on pulmonary defenses within cirrhotics is largely unknown. The purpose of this research was to identify defect(s) within innate host defenses in the cirrhotic host, and to examine the impact of pneumolysin on these defenses. The innate …
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Novel strategies to prevent and treat experimental pneumococcal disease
… that elicit non-serotype specific protection. Pneumolysin, the pore-forming toxin produced by S. pneumoniae, may play a role in future pneumococcal vaccine. It is a major virulence factor produced by all invasive isolates and has previously been demonstrated to confer non- serotype specific …
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Hearing loss in experimental bacterial meningitis
… defined isogenic derivatives of D39 deficient in pneumolysin, neuraminidase or hyaluronidase respectively. All animals developed a meningeal inflammatory response and a labyrinthitis. Hearing loss in pneumococcal meningitis was measured by recording the evoked auditory nerve compound action …
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Über die Auswirkungen systemischer bakterieller Begleitinfektionen bei Amyotropher Lateralsklerose
… Streptococcus Pneumonia freigesetzte Toxin Pneumolysin und den Angriff aktivierter Makrophagen reagierten als entsprechende Wildtyp-Zellen. Demgegenüber hatte eine Infektion von ALS-Mäusen mit Streptococcus Pneumonia keinen Effekt.
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Activation State of Human T and NK Cells Increases Sensitivity to Death by Streptococcus pneumoniae
… with pneumonia. When Spn undergoes cell lysis, pneumolysin (PLY) and other intracellular proteins are released. These intracellular proteins allow for Spn to acquire nutrients and to evade the host immune system. PLY is a cholesterol-dependent cytolysin and has been shown to be a major virulence …
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Mucins regulate virulence and colonization factors in Streptococcus pneumoniae
… factor of S. pneumoniae, the cytolytic toxin pneumolysin (PLY). I show that through the regulation of PLY, mucin protects host cells from toxin-mediated killing and modulates inflammatory signals. Second, I identify that mucins downregulate colonization factors in S. pneumoniae, modulating …
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Development of a novel co-vaccination approach for pneumococcal and influenza infections
… deletion of the autolysin gene and with the pneumolysin gene replaced with an allele encoding a non-toxic pneumolysoid. Intranasal administration of mice with γ-PN without an adjuvant was shown to elicit serotype-independent protection against pneumococcal challenge in models of sepsis and …
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Ecology of virulence genes in the human pathogen Streptococcus pneumoniae.
… and pathogenesis. The diversity in the toxin pneumolysin (Ply) was greater than previously thought, with 14 protein alleles discovered. However, diversity remained significantly lower than surface-exposed virulence factors, indicating this toxin may be more suitable as a vaccine candidate. …
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Immunodulation of inflammation in a murine pnemococcal sepsis model
… acid, peptidoglycan, and bacterial toxin pneumolysin. Adenosine has strong immunosuppressive and anti-inflammatory effects mediated by A2A receptor (A2AR) expressed on immune cells. We investigated the effect of A2AR agonist, ATL313, as adjunctive therapy in a lethal C57bl/6 mouse model of …