Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Pneumocystis"”.
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Over-expressed genes in pneumocystis carinii-infected rat lung
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Developing a diagnostic assay for Pneumocystis jirovecii pneumonia and investigating the interaction of Pneumocystis murina and respiratory syncytial virus during co-infection in mice
Pneumocystis pneumonia (PCP) is an AIDS-defining illness that is caused by an opportunistic fungal pathogen, Pneumocystis jirovecii. In immunocompromised individuals, P. jirovecii can result in fatal pneumonia, and healthy individuals can be reservoirs for P. jirovecii. PCP places a significant …
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EFFECT OF NICOTINE ON LUNG S-ADENOSYLMETHIONINE AND PNEUMOCYSTIS PNEUMONIA DEVELOPMENT
Infection with "Pneumocystis" causes a ≥ 99% depletion of plasma S-adenosylmethionine (AdoMet) levels in both "Pneumocystis" pneumonia (PcP) animal models and patients. AdoMet is a critical cellular metabolic intermediate, with a pivotal role as methyl donor in a myriad of biochemical processes and …
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The molecular diagnosis of Pneumocystis pneumonia in children using nasopharyngeal aspirate samples
Pneumocystis pneumonia (PCP) is an important opportunistic infection caused by thefungus Pneumocystis jirovecii. The incidence of PCP in sub-Saharan Africa is on theincrease. This is due to the progression of the HIV-pandemic and limited access to healthcare facilities, specific highly active …
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Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus
Pneumocystis pneumonia (PCP) is an important cause of morbidity and mortality amongst HIV-infected children in Africa. Definitive diagnostic resources for PCP in Africa are limited due to their expense and technical difficulty, however recognising and treating children at risk is essential. As …
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Investigating the role of the Dendritic Cell Immunoactivating Receptor in the Immune Response during Pneumocystis murina
Pneumocystis jirovecii causes fungal pneumonia in immunocompromised patients and can be fatal if left untreated. The global mortality rate is estimated to be over 200 000 in AIDS patients. In non-AIDS patients there is an estimated mortality rate of 50 000 cases. This rate is increasing in …
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Invasive fungal disease in immunocompromised hosts with focus on diagnostics
… controls were analyzed for betaglucan and Pneumocystis PCR. Pneumocystis PCR in serum had a very high sensitivity and negative predictive value for the diagnosis of PCP. Paper IV was a prospective nationwide study on lung transplant recipients where serum and BAL-fluid samples were …
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Diagnostic accuracy of C-reactive protein and procalcitonin, compared with composite reference standards, to discriminate between tuberculosis, Pneumocystis jirovecii pneumonia and bacterial pneumonia in HIV-infected inpatients meeting WHO criteria for seriously ill
… community-acquired pneumonia (CAP), and Pneumocystis jirovecii pneumonia (PJP) are the commonest causes of hospitalisation in HIV-infected individuals. Prompt diagnosis and treatment initiation are important to reduce morbidity and mortality, but are hampered by overlap in clinical and …
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Cryptosporidiosis in the Immunosuppressed Mouse and in Cell Culture
… caused by the opportunistic protozoan, <em>Pneumocystis carinii</em>. Tests were done with these mice housed in a room with other mice. In another test the were housed in a vinyl isolator in a separate room. These mice were fed a low (8%) protein diet and dexamethasone in their drinking …
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Pneumonia in HIV-infected children admitted to hospital in Cape Town, South Africa
… and pyogenic pneumonia predominating and Pneumocystis carinii pneumonia (PCP) occurring uncommonly. Knowledge of the aetiology and outcome of pneumonia is important for the development of paediatric management guidelines and of policies for allocation of resources especially in South …
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Design and Synthesis of Pyrimidine Based Heterocycles as Potential Anti-cancer Agents with Combination Chemotherapeutic Potential or Targeted One Carbon Metabolism Inhibition and Anti-opportunistic Agents
… for targeted tumor therapy; or c) selective <em>Pneumocystis jirovecii </em>(pj)<em> </em>dihydrofolate reductase (pjDHFR) inhibitors for pneumocystis pneumonia (PCP) infection.</p> <p>The work in this dissertation is centered on identifying structural features that are necessary for inhibition …
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Target Based Design and Synthesis of Fused Pyrimidines in the Potential Treatment of Cancer and Opportunistic Infection
… areas of agents designed as (a) selective <em>Pneumocystis jirovecii</em> dihydrofolate reductase (pjDHFR) inhibitors for pneumocystis pneumonia (PCP) infection; (b) inhibitors of microtubule polymerization and multiple receptor tyrosine kinase (RTK) for potential treatment of cancer; and (c) …
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Descripción de la microbiota fúngica presente en el tracto respiratorio de sujetos con enfermedad pulmonar obstructiva crónica
… ha sido determinada. Se conoce que hongos como Pneumocystis pueden alterar los valores de IL-8, IL-6 y TNF- a nivel sistémico en sujetos colonizados y posiblemente influir en la fisiopatología de la EPOC. Por otro lado, estudios recientes han demostrado que los β-glucanos, componente …
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Design and Synthesis of Pyrimidine Based Fused Heterocyclics in the Potential Treatment of Cancer and Opportunistic Infection
… and pyrazolo[4,3-<em>d</em>]pyrimidines.</p> <p>Pneumocystis pneumonia (PCP) is a form of pneumonia that is caused by the yeast-like fungus <em>Pneumocystis jirovecii</em>. The current treatment involving the use of a combination of trimethoprim and sulfamethoxazole is limited by drug resistance, …
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Radiological predictors of PCP in HIV-positive adults in South Africa: a matched case-control study
… features associated with laboratory-confirmed pneumocystis pneumonia (PCP) among HIV-positive adults is needed to improve diagnosis in high-burden settings. Methods: We conducted a case-control study involving HIV-positive adults with laboratory-confirmed PCP and a matched cohort with non-PCP …
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Radiological predictors of PCP in HIV-positive adults in South Africa: a matched case-control study
… features associated with laboratory-confirmed pneumocystis pneumonia (PCP) among HIV-positive adults is needed to improve diagnosis in high-burden settings. Methods We conducted a case-control study involving HIV-positive adults with laboratory-confirmed PCP and a matched cohort with non-PCP …
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Bioactivation of diacetyldapsone in cultured lung cells
… has been shown to be an effective agent against Pneumocystis carinii pneumonia, an opportunistic infection in AIDS patients. Oral administration of dapsone is associated with several adverse effects, including methemoglobinemia, hemolytic anemia and photosensitivity reactions. To reduce the …
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Target Based Design And Synthesis of Heterocycles in the Potential Treatment of Cancer and Opportunistic Infection
… reaction.<br /> Opportunistic infection by Pneumocystis jirovecii in immunocompromised patients such as organ transplant, cancer and AIDS patients is associated with high mortality. The current treatment involving the use of a combination of trimethoprim and sulfamethoxazole is limited by …
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Identification of potential pathogens of pneumonia in sputum samples from adult patients at the University Teaching Hospital in Lusaka
… (5.5%, 10/181), M. catarrhalis (4.4%, 8/181), Pneumocystis jirovecii (3.9%, 7/181), Respiratory Syncytial Virus (RSV) A/B (3.9%, 7/181), Adenovirus (1.7%, 3/181), Human bocavirus (1.1%, 2/181), Human metapneumoviruses A/B (1.1%, 2/181), Parainfluenzae type 1 (1.1%, 2/181), Parainfluenzae type 2 …
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Identification of potential pathogens of pneumonia in sputum samples from adult patients at the University Teaching Hospital in Lusaka
… (5.5%, 10/181), M. catarrhalis (4.4%, 8/181), Pneumocystis jirovecii (3.9%, 7/181), Respiratory Syncytial Virus (RSV) A/B (3.9%, 7/181), Adenovirus (1.7%, 3/181), Human bocavirus (1.1%, 2/181), Human metapneumoviruses A/B (1.1%, 2/181), Parainfluenzae type 1 (1.1%, 2/181), Parainfluenzae type 2 …
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