Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"Pneumococcal"”.
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Host and pathogen genetics associated with pneumococcal meningitis
… of tissue surrounding the brain. In cases of pneumococcal meningitis (where the bacterium Streptococcus pneumoniae is the causat- ive agent) this causes severe inflammation, requiring intensive care and rapid antibiotic treatment. The contribution of variation in host and pathogen genetics to …
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Novel strategies to prevent and treat experimental pneumococcal disease
… in their ability to protect against invasive pneumococcal disease (IPD). The adult pneumococcal vaccine is composed of capsular polysaccharide from 23 of the most prevalent disease causing serotypes. Purely polysaccharide vaccines are unable to protect those most at risk; infants under the age …
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Tolerant effect of type 111 pneumococcal capsular polysaccharide in rabbits
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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DRY POWDER INHALATION OF PNEUMOCOCCAL VACCINE USING POLYMERIC NANOPARTICLES AS CARRIERS
… pneumoniae is the leading bacterial cause of pneumococcal diseases, of which pneumonia is the main cause of death amongst the immunocompromised, elderly over the age of 50 and children under the age of 5. Although vaccines such as pneumococcal polysaccharide vaccine 23, pneumococcal conjugate …
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Effect of Smoke Exposure and Ethanol Ingestion on Anti-Pneumococcal Host Defenses
… exposure alone did not increase intrapulmonary pneumococcal clearance. Pulmonary chemokine levels of two chemotactic chemokines were significantly increased by concurrent smoke exposure and EtOH ingestion, even though these differences did not result in alterations in PMN recruitment to the …
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Development of a novel co-vaccination approach for pneumococcal and influenza infections
… elicit serotype-independent protection against pneumococcal challenge in models of sepsis and pneumonia. In particular, vaccine efficacy was shown to be reliant on B cells and IL-17 responses. Importantly, immunisation promoted IL-17 production by γδ T cells, as opposed to conventional Th17 …
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The impact of educational interventions on influenza and pneumococcal vaccination rates in primary care
Background. Influenza and pneumococcal vaccinations are important therapies supported by national and international guidelines for preventing morbidity and mortality from respiratory illnesses in high-risk groups. The responsibility for delivering these vaccinations in the United Kingdom lies with …
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The Effects of Chronic Ethanol Ingestion and Smoke Exposure on Anti-Pneumococcal Host Defenses
… defense mechanisms that protect the host from pneumococcal pneumonia. However, the interactive, combined immunosuppressive effects of ethanol (EtOH) ingestion and smoke exposure remain ill defined. To study these effects, we used a rat model that mimics chronic alcohol abuse and smoking. Rats …
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Aetiology and presentation of childhood pleural infections in the post-pneumococcal conjugate vaccine era in South Africa
Complications of respiratory infections include pleural effusion (PE), associated with a high morbidity. Differentiating between PE caused by bacterial infections and Mycobacterium tuberculosis (TB) in endemic areas is difficult in children, impacting treatment. We investigated the aetiology of PE …
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The Pneumococcus Urinary Antigen Test Kit: Use in the laboratory for the presumptive diagnosis of pneumococcal bacteraemia
… on culture. Novel detection methods for invasive pneumococcal disease include PCR and antigen tests. We evaluated using a urine antigen test directly on selected blood cultures with appropriate Gram stain results, immediately after signalling positive for the rapid identification of S. pneumoniae …
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PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES
Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an …
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Diverse Immune Responses Mediated by Beta-Adrenergic and Corticotropin-Releasing Hormone Receptors in a Model of Pneumococcal sepsis
Neuroendocrine stimulation can impact disease states by regulating immune function. The purpose of our studies was to define the functional role of stress-induced neuroendocrine factors, catecholamines and corticotropin-releasing hormone (CRH) on immune responses involved in the pathogenesis of …
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Genetic Recombination in Pneumococcal Transformation: The Role of Integrity and Heterogeneity of Deoxyribonucleate Molecules, as Reflected in Kinetic Analysis
<p>Pneumococcal transformation has been used to study intramolecular genetic recombination. A kinetic technique is developed whereby the cumulative number of multiply-marked transformants is measured as a function of the duration of exposure to a multiply-marked DNA. Transformants accumulate with …
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The Role of Immune and Natural Specific Antibodies in Immunologic Paralysis and Immunity of Mice to Pneumococcal Polysaccharide Type Iii
Made available in DSpace on 2014-12-09T22:30:25Z (GMT). No. of bitstreams: 1 7013376.pdf: 2318309 bytes, checksum: 116611a8756aa3b145c6f82ddd030031 (MD5) Previous issue date: 1969
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Ecology of virulence genes in the human pathogen Streptococcus pneumoniae.
… of diversity present. Currently, there are two pneumococcal vaccines, both targeting the polysaccharide capsule. However, one vaccine is ineffective in the paediatric population, whilst the other only targets a minority of disease-causing serotypes, and has increased disease caused by serotypes …
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Modelling the ecology and epidemiology of Streptococcus pneumoniae and their impact on conjugate vaccination
… a 7-valent conjugate vaccine protective against pneumococcal carriage and disease was introduced into the national immunisation programme in the UK. This thesis assists with the assessment of the population impact of this vaccine and its 13-valent successor. The thesis links the observations in …
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Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study
… of pneumonia and yet the dynamic nature of pneumococcal colonization remains incompletely understood. In children, asymptomatic colonization of the nasopharynx by the pneumococcus is common and also serves as a reservoir for person-to-person transmission. We aimed to investigate in detail, …
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Genomic diversity in naturally transformable Streptococcus pneumoniae
… perspective and to relate these observations to pneumococcal molecular epidemiology in a region of high biodiversity, the pathogenesis of certain disease manifestations and assess for a possible bacterial genetic basis for the pneumococcal phenotypes of, “carriage” and, “invasion.” In order to do …
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Interactions between influenza A virus and Streptococcus pneumoniae in nasal colonization and middle ear infection
… which viral infection predisposes to increased pneumococcal infection. Unclear, however, are the roles of specific pneumococcal factors in this coinfection process. This study was undertaken to examine the largely unexplored importance of two such factors of S. pneumoniae in coinfection with …
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