Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Pms1"”.
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Investigating DNA remodeling in DNA mismatch repair
… clamp (PCNA)-stimulated endonuclease Mlh1-Pms1/PMS2 (yeast/human), which nicks the DNA distal to the mismatch location and a pre-existing single strand break, that may allow the pathway to distinguish between DNA strands. The Mlh1-Pms1/PMS2-generated nick allows downstream proteins to …
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Visualizing the One-Dimensional Diffusion of DNA Mismatch Repair Proteins at the Single-Molecule Level
… DNA by the protein complexes Msh2-Msh6 and Mlh1-Pms1 in order to locate and remove mispaired bases. The details of these critical processes remain poorly understood, largely due to a lack of experimental methods capable of probing these dynamic processes. A custom total internal reflection …
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THE DNA DAMAGE CHECKPOINT REGULATES MISMATCH REPAIR COMPLEXES DURING SINGLE STRAND ANNEALING PATHWAY
… for repair. We found that the deletion of PMS1 gene, which expresses an endonuclease involved in the mismatch repair, strongly reduced SSA repair of rad1∆rad9∆ cells by Southern blotting analysis in our genetic system. Moreover, by chromatin immunoprecipitation, rad1Δrad9Δ cells exhibited …
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Γενετική ανάλυση στον κληρονομικό καρκίνο του μαστού
… ATM, BARD1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, RAD50, RAD51C) με την χρήση τεχνολογίας αλληλούχισης επόμενης γενεάς. Για το σκοπό αυτό αναλύθηκαν 42 ασθενείς με σοβαρό ιστορικό καρκίνο μαστού ή/και ωοθηκών, οι οποίες είχαν βρεθεί αρνητικές για μεταλλάξεις στα γονίδια BRCA1 & 2. Κατά …
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New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… MMR heterodimers MLH1-MLH3, MLH1-PMS2, and MLH1- PMS1. A biomathematical model of competition between MIP-box proteins for binding the MLH1 MIS suggests increased interaction between BLM and MLH1 when FAN1 or EXO1 is depleted. I propose a model in which FAN1 suppresses CAG repeat expansion by …