Global ETD Search
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Showing 1 to 1 of 1 for “"Ploidy-specific lethal genes"”.
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Whole genome doubling confers unique genetic vulnerabilities on tumor cells
… unstable tetraploid cells that fuel tumorigenesis. Cells that undergo WGD must acquire adaptive characteristics to accommodate their tetraploid state, and these adaptations may confer unique vulnerabilities that can be exploited therapeutically. We analyzed the genomes of ~9,700 primary …