Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Plexin"”.
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Characterizing New Molecules and Mechanisms of Semaphorin/Plexin/MICAL Signaling
… binding partners of the Semaphorin receptor Plexin. Combining Drosophila genetics with in vitro biochemical assays, my work revealed that Mical regulates actin organization both in vivo and in vitro and is a novel actin disassembly factor. These results provide a new basis for understanding …
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Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective
The Semaphorin-Plexin signaling is important for regulating axon guidance. Binding of Semaphorin to the Plexin receptor induces the dimerization of Plexin and stimulates its cytoplasmic GAP activity towards Rap, resulting in cytoskeleton re-organization. The growth cone of an axon then turns …
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Modelo de inteligencia de negocios para optimizar el proceso de toma de decisiones en PLEXIN SAS
Este proyecto tiene como objetivo potenciar la toma de decisiones en Plexín S.A.S. a través del despliegue de una solución de inteligencia corporativa. En la actualidad, la compañía se topa con desafíos en la gestión de datos, dado que numerosos procedimientos se realizan de manera manual y …
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Regulation of Mical Redox Post-Translationally-Driven F-Actin Cytoskeletal Dynamics
… associates with both the Semaphorin receptor Plexin and F-actin to post-translationally oxidize actin on its conserved methionine-44 and methionine-47 residues, inducing both F-actin disassembly and altered actin polymerization. Our work has also revealed that this Mical-mediated actin …
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Neural Stem Cells as a Model to Study Huntington’s Disease
… RRAS, the downstream signaling components of Plexin/Semaphorin pathway of the neurons. Our work began with optimization of the growth conditions of the cell lines of our model cell system. We then focused on developing protocols for differentiation into neurons, and continued with …
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Tissue-Specific Matrix Control of Cell Cohesion and Migration Signaling Complexes
… I hemidesmosomes and the perlecan-semaphorin 3A-plexin A1-neuropilin-1 (PSPN) complex) and translates this knowledge into viable solutions for both tissue engineering and cancer metastasis applications. Database (Matrisome/FANTOM5) and two-dimensional and three-dimensional cell culture analysis …
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Sema-1a Reverse Signaling Promotes Midline Crossing In Response To Secreted Semaphorins
… where Sema1a triggers repulsion through Plexin binding, in commissural neurons Sema-1a acts independently of Plexins to inhibit Rho and promote attraction to the midline. These findings suggest that Sema-1a reverse signaling can elicit distinct axonal responses depending on differential …
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Direct Redox Regulation of F-Actin Assembly and Disassembly by MICAL
… with the Semaphorin cell-surface receptor Plexin and are important for Semaphorins to exert their effects. Nothing was known, however, regarding the specific role of the MICALs in these Semaphorin-dependent events. Not long after I began my graduate work, my colleagues and I noticed that …
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Direct Redox Regulation of F-Actin Assembly and Disassembly by MICAL
… with the Semaphorin cell-surface receptor Plexin and are important for Semaphorins to exert their effects. Nothing was known, however, regarding the specific role of the MICALs in these Semaphorin-dependent events. Not long after I began my graduate work, my colleagues and I noticed that …
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Plxna4 and its role in neuronal survival in the developing zebrafish hindbrain
Plexins are a family of transmembrane proteins that bind Semaphorin ligands, and are known to function in axon guidance. In embryonic zebrafish, I find that plxna4 is expressed widely in the nervous system early in development, and localizes to the hindbrain as neurogenesis and differentiation …