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Showing 1 to 1 of 1 for “"Pleuromutilin analogs"”.
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Discovery of Natural Product-based Antimycobacterial Agents Effective against Non-replicating Bacilli
… of a 400-membered library of aurachin RE analogs resulted in discovery of UT-317 ((R)-20). UT-317 is a selective vitamin K2 biosynthesis (MenA) inhibitor that killed replicating and non-replicating Mtb at 2.31 μg/mL (MIC) and 0.85 μg/mL, respectively. A 50-membered library of capuramycin …