Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Pleiotrophin"”.
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Pleiotrophin inhibits melanogenesis in normal human melanocyte
Pleiotrophin (PTN) is a secreted heparin-binding protein that is involved in various biological functions of cell growth and differentiation. Little is known about the effects of PTN on the melanocyte function and skin pigmentation. In this study, we investigated whether PTN would affect …
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The Impact of Pleiotrophin on Breast Cancer Progression
Page xiv is misnumbered as page xv.
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… epidermal growth factor (HB-EGF), midkine (MK), pleiotrophin (PTN), and cluster differentiation (CD105). The localisation of HBGFs and receptors VEGFR-1, /(sflt-1), PLGFR-1, VEGFR-2 and FGF2R-1 in placenta were detected. The expression of VEGF, PLGF, FGF2, HGF, PDGF, CD105 was confined to villous …
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Anti-VEGF Therapy Modulates Immune Cell Infiltration and Function in Multiple Breast Cancer Models
… corresponding to an increase in the cytokine pleiotrophin (PTN). Once expressed, PTN stimulates the phosphorylation of anaplastic lymphoma kinase on tumor associated macrophages. These macrophages promote anti-inflammation, angiogenesis, immune tolerance, and metastasis. Importantly, these …
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Cell Patterning: Building Living Neural Networks
… of extracellular matrix protein (laminin or pleiotrophin with or without polylysine). These substrates were fabricated by sequentially binding biomolecules to substrates with polydimethylsiloxane microstamps. On laminin/polylysine versus polylysine, 80% of neurons near the border extended …
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Protein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem Cell Self-Renewal
… that a heparin binding growth factor, Pleiotrophin (PTN), promotes the expansion of murine long-term (LT)-HSCs via binding to a PTP, protein tyrosine phosphatase receptor type Z (PTPRZ). The addition of PTN to murine PTPRZ-/- c-Kit+Sca-1+Lineage- (KSL) cells caused no expansion of HSCs …
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Molecular mechanisms of floor plate formation and neural patterning in zebrafish
… higher vertebrates, mdk and the related factor pleiotrophin (ptn) are widely expressed during embryogenesis and are implicated in a variety of processes. The in-vivo function of both factors, however, is unclear, as knock-out mice show no embryonic phenotype. We have isolated two mdk …
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Elucidation of the roles of PTN and ISG15 in RSV cytopathogenesis: possible biomarkers of severe disease?
… genes, interferon‐stimulate gene 15 (isg15) and pleiotrophin (ptn), were of particular interest based on published work identifying the anti‐viral role of ISG15 in a number of viral illnesses and the established interaction of PTN with the recently identified RSV co‐receptor/entry factor, …
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Ταυτοποίηση πρωτεϊνών που αλληλεπιδρούν με τον αυξητικό παράγοντα πλειοτροπίνη και διερεύνηση του λειτουργικού τους ρόλου
Η πλειοτροπίνη (PTN) αποτελεί έναν αυξητικό παράγοντα με ποικίλες δράσεις και σημαντικό ρόλο στην ανάπτυξη όγκων και την αγγειογένεση. Διάφοροι υποδοχείς αλληλεπιδρούν με την ΡΤΝ και διαμεσολαβούν τις βιολογικές της δράσεις, όπως η Ν-συνδεκάνη, ο ALK (κινάση αναπλαστικού λεμφώματος) και ο RPTPβ/ζ …