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Showing 1 to 7 of 7 for “"Pleckstrin Homology domain"”.

  1. Analysis of the Interaction and Functional Determinants of Arc and Its Regulation of Dynamin

    Byers, Christopher Eugene2011

    … studies show Arc interacts with the proline-rich domain of dynamin and not the pleckstrin homology domain. All together, these results provide a mechanism to explain the previously reported role of Arc in glutamate receptor internalization.

    utswmed Repository record

  2. A screen for phosphatidylinositol 3,4-bisphosphate and other 3-phosphoinositide effector proteins

    Dixon, MilesUniversity of Dundee2010

    … proteins. The identification of tandem pleckstrin homology domain containing protein-1 (TAPP-1) and protein kinase B (PKB) among a multitude of proteins expressing known lipid binding domains (LBDs) demonstrates the utility of this strategy. Analysis of other similarly, isotopically …

    dundee Repository record

  3. Phosphatidylinositol 3-phosphate binding properties and autoinhibition mechanism of Phafin2

    Tang, TuoxianVirginia Tech2021

    … Phafins are modular with an N-terminal PH (Pleckstrin Homology) domain followed by a central FYVE (Fab1, YOTB, Vac1, and EEA1) domain. Both the Phafin2 PH and FYVE domains bind phosphatidylinositol 3-phosphate [PtdIns(3)P], a phosphoinositide mainly found in endosomal and lysosomal …

    vt Repository record

  4. Protein-Protein Interactions and Muscle cell Signaling Via Syntrophin

    Oak, Shilpa A.2016

    … Oligomerization was localized to the N-terminal pleckstrin homology domain (PH1) or adjacent sequences; the second, C-terminal PH2 domain did not show oligomerization. PH1 was found to se lf-associate and calmodulin or Ca<sup>2+</sup> chelating agents such as EGTA could effectively prevent this …

    tenn-hsc Repository record

  5. Molecular mechanisms regulating phospholipase C-gamma 2 activity

    Bühler, AnjaUniversität Ulm

    ulm-diss Repository record

  6. Targeting Ph Domain Proteins For Cancer Therapy

    Tan, Zhi, <p>0000-0003-1895-0285</p>2019

    … critical to new and promising targeted therapy. Pleckstrin Homology (PH) domain proteins are one of the biggest protein families in the human proteome. However, no drugs have been achieved to the late development stages, let alone getting to the market. Thus, a deeper understanding of this …

    uthsc Repository record

  7. Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins

    Singh, NilmaniUniversity of Illinois at Urbana-Champaign2021

    … I have examined the binding characteristics of Pleckstrin Homology (PH) domain, a lipid-binding domain, with phosphoinositides (phosphatidylinositol phosphates or PIPs), an important class of regulatory phospholipids. PH domains are presumed to bind PIPs, but specific interaction with and …

    uiuc Repository record