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Showing 1 to 1 of 1 for “"Pleckstrin Homology Domains"”.
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Regulation of p190RhoGEF by Activated Rho and Rac GTPases: Amplification and Crosstalk
… RhoGEFs, the exchange activity resides in a Dbl homology (DH) domain, which is linked to a pleckstrin homology (PH) domain that subserves various functions. We have crystallized and solved structures of the PH domain from p190RhoGEF bound to either RhoA•GTP or Rac1•GTP. The interfaces between …