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Showing 1 to 4 of 4 for “"Platinum chemotherapeutics"”.
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CRISPRi screens to identify combination therapies for the improved treatment of ovarian cancer
… surgical debulking followed by a combination of platinum and taxane agents, but relapse and resistance frequently occur. To identify genes that confer sensitivity or resistance in tumor cells treated with platinum chemotherapeutics, I performed genome-wide screens combining cisplatin or …
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Drug Design, Biological Activity, and Metabolic Consequences of Cytotoxic Platinum Compounds: Utilizing Fluorescent Tagging to Understand Drug Action and Metabolism
Platinum drugs are among the most commonly used chemotherapeutics for the treatment of testicular, head and neck, ovarian, small cell lung, and colorectal carcinomas. Although the current set of platinum chemotherapeutics has proven somewhat successful, the overall success of platinum based drugs …
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Effect of platinum chemotherapy on tumour infiltrating immune cells in metastatic ovarian cancer: Mechanistic insights and therapeutic applications
Platinum chemotherapeutics remain standard of care for many cancer patients, including high grade serous ovarian cancer. It is becoming clear that chemotherapy can initiate adaptive immune responses to the cancer, however, it remains unclear to what extent innate Natural Killer (NK) cells …
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Platinum(II) Compounds and Nucleolar Stress
Platinum(II) chemotherapeutic agents represent a critical class of anticancer compounds. The clinical use of these compounds is limited by side effects and development of resistance. Despite these limitations, the three FDA approved Pt(II) drugs – cisplatin, carboplatin, and oxaliplatin – remain an …