Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Platelet-derived growth factor (PDGF)"”.
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Investigation of the role of Platelet-Derived Growth Factor (PDGF) in the development of breast carcinomas
Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, September 2002.
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Involvement of Platelet-Derived Growth Factor, PDGF Receptor Signaling, Focal Adhesion Kinase and SRC in Pressure-Induced Vascular Smooth Muscle Hypertrophy
… we targeted cell surface integrin and growth factor receptors thought to be mechanically sensitive. The signaling molecules FAK, Src and ERK-MAPK are known to be triggered by integrin engagement and growth factor receptor tyrosine kinase (RTK) activation. Pairs of rat mesenteric …
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Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
In addition to steroid hormones, signaling by platelet-derived growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities …
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Chemotaxis of Central Nervous System-derived Tumor Cells within Controlled Microenvironments
… in vitro migratory and cellular responses of MB-derived cells to external signaling of Epidermal Growth Factor (EGF), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF-BB), and the stromal cell-derived factors 1-alpha (SDF-1). Experiments utilized transwell assays and …
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The Regulation and Mechanism of Myelin Synthesis Involving Endogenous Steroid Hormones
In conjunction to the previous study, the platelet-derived growth factor (PDGF) A-chain was detected as two distinct splice variants in Schwann cell/neuronal co-cultures. Both PDGF A-chain isoforms were characterized and examined throughout the myelination process. The mRNA for the long form PDGF …
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Sensory Primary Cilium is a Distinct Signaling Compartment
… pathways such as Hedgehog (Hh), Wnt, and platelet-derived growth factor (PDGF) pathways during development and tissue homeostasis. The primary cilium has been established as a mechano, chemo- and osmosensing unit that transmits extracellular cues to the cell, which supports the importance …
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Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression
<p>Platelet Derived Growth Factor (PDGF) is a family of mesenchymal growth factors that regulate cell proliferation, migration, and differentiation. Unlike the classic PDGF ligands A and B, which are secreted as active dimers, PDGF D must undergo extracellular proteolytic processing to remove its …
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A Microfludic Assay Device for Study of Cell Migration on ECM-mimicking Suspended Nanofibers in Presence of Biochemical Cues
… mouse embryonic fibroblast NIH/3T3 response to platelet derived growth factor (PDGF) on flat polystyrene and suspended, polystyrene nanofibers with small (15 μm), and large (25 μm) spacing. Cell aspect ratio is lowest for flat polystyrene (spread morphology) and highest for large-spaced fibers …
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Nanoparticle effects on cell migration
… examined was human dermal fibroblasts (HDF) and platelet-derived growth factor (PDGF). Cells were cultured and placed into 3D collagen gel in a specialized chemotaxis slide, in which a steady chemoattractant concentration was produced. Cell migration was recorded through bright-field optical …
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… hypothesis that expression of heparin-binding growth factors (HBGFs) in normal placental development was altered in a specific pregnancy disorder preeclampsia. HBGFs bind to heparin, a glycosaminoglycan (GAG) affecting activity. I investigated the role of heparin and HBGFs in pathophysiology of …
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Rapid Rac GTP-ASE activation in live cells by mechanical stress is independent of Src
… ms) of Rac at the cell periphery. In contrast, platelet derived growth factor (PDGF) induced Rac activation at a much later time (>30 sec). It is known that PDGF-induced Rac activation depends on Src activity. There was no stress-induced Rac activation when a mutant form of the Rac biosensor …
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The Isolation and Characterization of Growth Regulatory Factors Produced by a Herpes Simplex Virus Type 2 Transformed Mouse Tumor Cell Line, H238
… to associate HSV-2-transformation with specific growth factors in order to develop a testable model for HSV-2-transformation. For some tumor viruses, particularly those containing RNA, there has been a central concept (autocrine secretion) linking oncogenes and growth factors. This concept …
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Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor
… cell carcinomas (HNSCC) express angiogenic factors such as vascular endothelial growth factor (VEGF). Since radiotherapy is one of the most commonly used treatments for HNSCC, it is imperative to identify the interactions between antiangiogenic therapy and radiotherapy, and to develop …
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Studies of SV40-transformation and the Loss of Growth Factor Requirements
… induced the loss of several specific growth factor requirements. In particular, SV40 transformed 3T3 fibroblasts had a significantly reduced growth requirement for insulin. A reduced insulin requirement was also observed in several other transformed cell lines. Dose response studies …
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Characterization of an Alternatively Spliced Platelet-Derived Growth Factor Variant During Myelin Synthesis
An alternatively spliced platelet-derived growth factor (PDGF) A-chain isoform was detected in rat dorsal root ganglion (DRG) neuron/Schwann cell cocultures and shown to regulate myelin synthesis. mRNA transcripts of the long-form PDGF-A chain variant (LF-PDGF-A) were detected by RT-PCR in …
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Layer-by-Layer Systems for Craniomaxillofacial Bone Repair
… increasingly recognized that release rate of growth factor proteins signaling bone regeneration and vascularization is a key optimization parameter since these proteins are rapidly cleared from the body and can have safety ramifications when released too rapidly. A clear delivery challenge …
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Investigation of the application of polylactic acid-calcium phosphate composite materials as novel periodontal barrier membranes
… determined in simulated body fluid (SBF). The growth and differentiation of PDL cells and osteoblasts were assessed on PLA-nHA composite films and the ability of these films to carry platelet derived growth factor (PDGF) and its effect on osteoblast growth was investigated. Further, fibre …
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MEMS-based temperature-dependent characterization of biomolecular interactions
… sensing, using a demonstrative system of platelet-derived growth factor (PDGF) and an inhibitory ligand. The temperature-dependent kinetic and equilibrium binding properties are determined. In addition, a microfluidic approach for temperature-dependent biomolecular behavior with …
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Effects of transvaginal follicular aspiration on oocyte recovery, hormonal profiles before and after GnRH, and growth factor influence on embryo development
… in cows. A second objective was to determine if platelet-derived growth factor (PDGF-BB) and leukemia inhibitory factor (LIF) exhibit a stimulatory effect during in vitro co-culture with Buffalo Rat liver cells (BRL). Oocytes were matured in transit, fertilized in vitro, and embryos were …
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The role of mitochondria in regulating smooth muscle cell proliferation and migration in pulmonary hypertension
… signalling in response to platelet-derived growth factor (PDGF) and hypoxia. Aims were first to determine the appropriate model of hypoxia-induced cell proliferation among different degrees of hypoxia. The second aim was to investigate the role of the mitochondria in …
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