Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Platelet aggregation"”.
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Investigating small-molecule inhibitors of platelet aggregation
… infarction is arterial thrombosis, driven by platelet aggregation. Adenosine diphosphate (ADP)-induced platelet aggregation is mediated by the Gi-protein-coupled receptor (GPCR), P2Y12. Therefore, P2Y12 antagonists are clinically used to prevent thrombotic events. However, current antiplatelet …
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Computational modeling of extravascular platelet aggregation under flow
Platelets in blood aggregate as part of the normal physiologic response to a blood vessel injury. Extravascular injuries, those that occur outside the blood vessel, are not well understood and lack numerical tools to study them. In this research, we develop and validate numerical tools to study …
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Magnesium Transport In Mammalian Erythrocytes And Its Effect On Platelet Aggregation
… The effects of varying extracellular Mg 2+ on platelet aggregation was also investigated employing different concentrations of adenosine diphosphate (ADP) on the plasma from both pre- and post-dialysis patients. Healthy human controls were used as a comparison. The Mg 2+ level in plasma from …
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Sulfatides mediate Disabled-2 membrane localization and stability during platelet aggregation
… of the blood as the result of deregulated platelet aggregation. During the repair of vascular injury, clotting usually occurs when platelets adhere to each other at the site of vascular injury in order to stop bleeding.2 Distinct protein receptors and adhesive ligands together with the …
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In vitro anti-platelet aggregation activity of the extracts of bulbine natalensis
… The aim of this research was to test the anti-platelet aggregation effect of B.natalensis’ extracts on rat platelet aggregation separately induced by thrombin, ADP, collagen, epinephrine, papain, bromelain and trypsin. Fresh plant material was extracted sequentially using hexane, chloroform, …
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In vitro anti-platelet aggregation activity of the extracts of protorhus longifolia
Platelet aggregation beyond purpose of haemostasis is the underlying cause of blood-clotting related diseases. Concoctions of P. longifolia are used by Zulu traditional healers to manage such diseases. This work aimed at investigating the anti-platelet aggregation activity of the extracts of this …
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
Abnormal Platelet aggregations are implicated in the onset of cardiovascular diseases which are the leading cause of death and disability globally. Management of pathological platelet aggregation with medicinal plants is a promising approach in treatment of cardiovascular diseases. In this study, …
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Inhibition of human platelet aggregation by perhexiline maleate : mechanisms and therapeutic implications / Scott Richard Willoughby.
Experiments described in the thesis address the anti-aggregatory effects and mechanism of action of the prophylactic anti-anginal agent perhexiline maleate. In particular, it was sought to examine if perhexiline had an anti-aggregatory effect which may contribute to its proven therapeutic efficacy.
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Adiponectin : a novel circulating anti-thrombotic factor in humans?
… although it has been reported to modulate platelet function and thrombosis. In this study the effects of globular adiponectin (gAd), a novel platelet agonist that stimulates platelet aggregation was characterised. While it had been previously noted that gAd stimulated platelet aggregation …
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The role of reactive nitrogen species and aged garlic extract on platelet function
… with studies indicating that AGE can inhibit platelet aggregation both in vivo and in vitro. The mechanism of inhibition induced by AGE is proposed to be due to AGE exerting effects upon several targets within platelets, including calcium and cyclic adenosine monophosphate (cAMP). The effect …
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Disabled-2 regulates platelet heterotypic and homotypic aggregation through sulfatide binding
At the site of vascular injury platelet aggregation serves to stem blood flow, initiate the inflammatory response, and stimulate wound healing. Platelets become stimulated, release their granule contents, and become adherent to one another. Platelet granules contain important clotting factors and …
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Protective Effects of Yuzu and Its Component against Cardiovascular Disease
… impact on the LV remodeling process after MI and platelet aggregation. In this study, it was investigated whether yuzu and its components hesperidin and naringin, have anti-platelet activities. Yuzu and hesperidin inhibited collagen-, arachidonic acid (AA)-, ADP- and thrombin-induced rat platelet …
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Chrysophanol-8-O-glucoside Attenuates Platelet Activation Through Inhibiting MAPK and PKCε
Platelets are key components of thrombosis and may also participate in the progression of cardiovascular diseases. Hence, the inhibition of platelet aggregation is important for preventing the progression of arterial thrombosis. Rhubarb is a widely used traditional medicine and has been reported to …
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The evaluation of novel nanoporous materials for use in interventional cardiology
… biological processes, including vasodilation and platelet aggregation prevention. Existing procedures for coronary interventions carry the potential for radial artery spasm, resulting in patient discomfort and frequently resulting in procedural complications at an early stage. This thesis …
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Study of patients with suspected platelet-based bleeding disorders: a search for patients with a defect in the P2Y12 ADP receptor
Mild platelet-based bleeding disorders are among the most complex bleeding disorders to understand, due to the absence of a ‘gold standard’ test for diagnosis and the significant overlap with the bleeding phenotype observed in healthy individuals. The work in this thesis is focussed on patients …
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Membrane binding properties of Disabled-2
… biological processes including endocytosis and platelet aggregation. During endocytosis, the Dab2 phosphotyrosine-binding (PTB) domain mediates protein binding to phosphatidylinositol 4,5-bisphosphate (PIP2) at the inner leaflet of the plasma membrane and helps co-localization with clathrin …
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Effects of thromboxane synthetase inhibition on blood cell function and morphology during ovine pregnancy-induced hypertension
Scanning and transmission electron microscopy and platelet aggregometry were employed to study erythrocyte morphology and thrombocyte morphology and function during ovine pregnancy-induced hypertension (OPIH). Nine multiparous gravid ewes were observed during normal pregnancy, OPIH, and thromboxane …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
Platelets are involved in many processes ranging from fighting microbial infections and triggering inflammation to promoting tumor angiogenesis and metastasis. Nevertheless, the primary physiological function of platelets is to act as essential mediators in maintaining homeostasis of the …
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