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Showing 1 to 20 of 38 for “"Platelet Function"”.
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Regulation of blood platelet function by nitric oxide
Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix resulting in platelet activation and aggregation to form a haemostatic plug. This self-amplifying mechanism requires a tight control to prevent uncontrolled platelet aggregate formation that could occlude the …
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Platelet Function in Dogs with Chronic Liver Disease
… acquired chronic liver disease have decreased platelet function and alterations in von Willebrand factor (vWF) that may contribute to hemostatic abnormalities. Hypothesis: Dogs with chronic liver disease have prolonged platelet closure time (CT), assessed with the PFA-100®, and buccal mucosal …
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Regulation of blood platelet function by the AGC family of protein kinases
Upon vascular injury, platelets aggregate at the site of blood vessel injury to form a hemostatic plug maintaining the physiological integrity of the vascular system. Platelets respond to a variety of extracellular stimuli to undergo a rapid aggregation response, releasing active granule contents …
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The role of reactive nitrogen species and aged garlic extract on platelet function
… with studies indicating that AGE can inhibit platelet aggregation both in vivo and in vitro. The mechanism of inhibition induced by AGE is proposed to be due to AGE exerting effects upon several targets within platelets, including calcium and cyclic adenosine monophosphate (cAMP). The effect …
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Platelet Function and Energy Metabolism During Storage in a Well-Defined Experimental Medium
<p>The most significant problem in maintaining platelet viability during storage is the decrease in pH resulting from accumulation of lactic acid formed by platelet anaerobic glycolysis. This study investigates nutrient alternatives to glucose for maintenance of morphology and functional integrity …
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Improving outcomes in patients with coronary heart disease using national registers and platelet function testing
… (clopidogrel pre-treatment, 5 different anti-platelet protocols, ticagrelor pre-treatment and treatment delays to PCI). Two papers involved evaluation of interventions: platelet function testing in patients with clopidogrel and clinical evaluation of bivalirudin versus heparin in patients with …
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The study of Platelet Function using Flow Cytometry to Assess Effectiveness of Platelets Transfusion Therapy
… count increments (CCI) following transfusion of platelets have been used as the indicator for assessing effectiveness of platelet transfusion therapy, however, CCI is not a indicator for the status of platelet function in transfused patients. Nevertheless, there are few reports that have studied …
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An investigation of the role of ACTN1 in platelet formation and of platelet function in myeloma
Platelet dysfunction may be inherited or acquired. In this study platelet dysfunction was assessed in both contexts; the inherited platelet disorder ACTN1-related Congenital Macrothrombocytopenia (CMTP) and the acquired prothrombotic state in Multiple Myeloma (MM). Actinin-1 is a widely-expressed …
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Platelet function Analyzer; closure times in children with congenital cyanotic heart disease A prospective observational pilot study
… assess whether the PFA could be used to guide platelet replacement in this population.
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Identification of Multiple Levels of Trauma Induced Coagulopathy
… cell focused research. As part of this shift, platelets have become a central player in hemostasis. Unfortunately little is currently understood about how platelet function is affected by trauma. In an effort to better define platelet function during trauma and the resulting shock from …
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Changes in the clotting viscoelasticity caused by cardiopulmonary bypass (CPB) surgery
… have abnormal bleeding due to acquired platelet dysfunction. Standard clotting tests to determine the cause of bleeding usually take between 25 and 60 minutes to get results. This time frame is not useful for deciding what type of treatment to give to a patient. More importantly, the …
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Mechanisms of platelet inhibition by the selective serotonin reuptake inhibitor citalopram
… by the serotonin transporter (SERT). Since blood platelets express SERT, SSRIs may modify platelet function and the risk of cardiovascular disease. However, the beneficial or adverse effects of SSRIs on arterial thrombosis are poorly characterised and detailed in vitro experimental data is …
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Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
… physiologic hemodynamics for the study of platelet deposition and coagulation using minimum volumes of human whole blood. This dissertation describes the application of microfluidic assays, the manipulation of surface-patterned procoagulant and sub-endothelial proteins, anti-coagulation, …
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Platelets : their exploitation and elimination
Platelets are cytoplasmic fragments present in large numbers within the bloodstream that contain a multitude of proteins. For a long time, platelet function was believed to be limited to the essential functions of haemostasis and thrombosis. However, it has become clear in the last decade that …
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Platelets : their exploitation and elimination
Platelets are cytoplasmic fragments present in large numbers within the bloodstream that contain a multitude of proteins. For a long time, platelet function was believed to be limited to the essential functions of haemostasis and thrombosis. However, it has become clear in the last decade that …
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A study of platelets and the endothelium in idiopathic pulmonary fibrosis
… an association between IPF and vascular disease. Platelets and the endothelium play an important role in maintaining vascular integrity, patency and function. In addition to their role in haemostasis, platelets have significant inflammatory and pro-fibrotic potential. Platelets and the lung have a …
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Aspects of bleeding complications and hemostasis at central line insertion and mild induced hypothermia
… supportive evidence is scarce, prophylactic platelet transfusion is sometimes performed in these patients before catheter insertion. Furthermore, the ideal threshold platelet count and timing of transfusion remain controversial among clinical studies. Hypothermia is generally considered to …
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Cytokine receptor-like factor 3 (CRLF3): A novel regulator of platelet biogenesis and potential drug target for thrombocythaemia
Thrombocythaemia is defined as a circulating platelet count above 450x10$^9$/L in humans. The major cause of thrombocythaemia is reactive $(secondary)$ thrombocythaemia which occurs secondary to many conditions such as infection, cancer and inflammation. However, acquired clonal mutations in mainly …
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The Evolution of Platelet Responses to Collagen Under Conditions of Hemodynamic Flow
Collagen activates platelets through the immune-type GPVI receptor, but the mechanism by which this receptor has adapted to function in platelets under conditions of rapid blood flow is unclear. Additionally, it is unknown if responses to collagen are conserved in nucleated thrombocytes found in …
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