Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"Platelet Activation"”.
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
Platelets are involved in many processes ranging from fighting microbial infections and triggering inflammation to promoting tumor angiogenesis and metastasis. Nevertheless, the primary physiological function of platelets is to act as essential mediators in maintaining homeostasis of the …
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NOVEL REGULATORS OF GPVI-MEDIATED PLATELET ACTIVATION
Platelets are anucleate cells that are crucial mediators of hemostasis and thrombosis. Under physiological conditions, platelets are maintained in a quiescent state within the vasculature. Upon vascular injury, an essential receptor that initiates platelet activation upon interaction with …
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The Molecular Mechanism of Platelet Activation in Inflammation
… the role of extracellular histones in platelet activation, exploring their pro-thrombotic effects and the molecular pathways involved. Using flow cytometry, platelet activation was quantified through P-selectin (CD62P) expression, revealing a dose-dependent response, with 91.6% …
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Regulation of Syk activity in GPVI-mediated platelet activation
Activation of platelets is essential for hemostasis. Following damage to the vascular endothelium collagen is exposed, to which platelets stably adhere. After adhesion on collagen, a signaling cascade is initiated, mediated by Glycoprotein VI (GPVI), which results in platelet activation. A major …
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The influence of oxidised low density lipoproteins on platelet activation
… low density lipoproteins (LDL) may contribute to platelet hyperactivity and thrombotic events in cardiovascular diseases. Although these pathological particles are known to stimulate platelet activation, the exact signalling mechanisms involved are poorly defined. The aim of this study was to …
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Chrysophanol-8-O-glucoside Attenuates Platelet Activation Through Inhibiting MAPK and PKCε
Platelets are key components of thrombosis and may also participate in the progression of cardiovascular diseases. Hence, the inhibition of platelet aggregation is important for preventing the progression of arterial thrombosis. Rhubarb is a widely used traditional medicine and has been reported to …
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Interaction between RSNO and H2S: The formation, stability, and NO-donating capacity of SSNO- and the effect of SSNO- on platelet activation
… further demonstrated the stability of SSNO- in platelet-rich plasma, in which, the inhibition of platelet activation in platelets treated with SSNO- is comparable to those treated with S-nitrosoglutathione (GSNO).
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Novel Agonists and Antagonists of Platelet Receptors
Platelets are central for the primary haemostatis. The platelet has surface bound receptors that are vital for the platelet activation. One of these receptors, the purinergic ADP-activated G-protein coupled receptor (GPCR) P2Y12 is a key receptor for platelet activation, and thus for thrombus …
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Platelet Receptor Glycoprotein VI in Ischaemic Stroke
Platelet activation, thrombus growth and subsequent thromboembolism underpins the pathophysiology of ischaemic stroke. At sites of atherothrombotic plaque rupture, it is established that platelet surface receptor glycoprotein (GP) VI-dimer binds to exposed sub-endothelial collagen, initiating the …
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Structural basis for sulfatide recognition by Disabled-2
… processes, including protein endocytosis, platelet activation and aggregation, tumor growth, and development. In platelets, Dab2 associates with membrane sulfatide at the platelet surface, modulating platelet inside-out and outside-in signaling pathways. A Dab2-derived peptide, named the …
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Rheumatoid arthritis and atherosclerosis: common pathogenic mechanisms explored
… Glycoprotein VI (sGPVI), a specific marker of platelet activation, providing further evidence that platelet activation is associated with seropositive RA and is likely antibody mediated. Together this body of work identifies shared pathogenic mechanisms between RA and atherosclerosis and …
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1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine (Platelet Activating Factor): Interactions with Sheep Platelets
<p>Platelet Activating Factor (PAF) seems to link platelet function with allergy and inflammation. Early events associated with the action of PAF on platelets are poorly understood, but PAF appears to interact with a platelet membrane receptor. Two photoaffinity-labelling analogs of PAF, …
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Studies on formation and stabilization of pathological thrombi in vivo
Platelet activation and adhesion resulting in thrombus growth is essential for normal hemostasis, but can lead to irreversible, life-threatening vessel occlusion. In the current study, the contribution of platelet integrins, activation receptors and the contact system of blood coagulation in such …
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A Microfluidic Approach For Investigating The Role Of Blood Flow In Thrombosis
… microfluidic device was designed to shear platelet-free plasma at pathological rates to aggregate von Willebrand factor (VWF) into insoluble fibers held in place by a micropost. VWF fibers were non-amyloid and resistant to ADAMTS13 and tissue plasminogen activator. Factors XIIa and XIa were …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
Platelets orchestrate haemostasis through receptor-mediated adhesion, aggregation, and secretion. Platelet dysfunction can lead to bleeding and/or clotting disorders but is challenging to diagnose clinically. This thesis focuses on immune thrombocytopenia (ITP), a disorder marked by immune-mediated …
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Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins
GPVI activates platelets through an ITAM pathway by activation of Src and Syk kinases leading to activation of PLC\(_y\)2. CLEC-2 has been shown to activate platelets using an ITAM-like sequence in its cytoplasmic tail that is also dependent on Src and Syk kinases, but shows a partial rather than …
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Platelets and Anti-Angiogenic Resistance In Ovarian Carcinoma
… clinical impact of anti-angiogenic. Platelets represent a component of the tumor microenvironment that are implicated in metastasis and represent a significant reservoir of angiogenic regulators. Thrombocytosis has been shown to be caused by malignancy and associated with adverse …
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The Influence of Resistance Training on Primary Hemostatic Responses
… in helping to reduce the hyperaggragability of platelets following acute strenuous exercise. The present investigation was designed to explore the effects of an acute resistance exercise test (AERET) and recovery on the primary hemostatic system in both resistance trained and untrained …
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An investigation of the structure and function of the receptor-type protein tyrosine phosphatase CD148
… protein tyrosine phosphatase (RPTP) found on platelet surfaces, where it has a vital dual role in regulating platelet signalling and thrombosis. Inhibition of CD148 has been suggested as a novel anti-thrombotic strategy. Loss-of-function polymorphisms located in the extracellular domain (ECD) …
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