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Showing 1 to 20 of 541 for “"Platelet"”.
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Comparison of platelet counting technologies in equine platelet concentrates
Platelet rich plasma (PRP) is a popular autologous biological therapy used for the treatment of various equine ailments, including tendon and ligament injuries, osteoarthritis, and cutaneous wounds. A number of commercial products are available for producing PRP, each generating a slightly …
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The Tetraspanin CD9 Localizes to Platelet-Platelet Contacts and Regulates Thrombus Stability
… the tetraspanin family, is highly expressed on platelets (50,000-80,000 copies per platelet). Tetraspanins have been implicated in modulation of integrin function, and it is hypothesized that CD9 will modulate GPIIb-IIIa, the major platelet integrin.</p> <p> The association between CD9 and …
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Platelet adhesion in atherogenesis
Platelets are known to play a key role in acute coronary events, such as myocardial infarction, associated with advanced atherosclerosis, but a number of papers have recently been published suggesting that platelet adhesion may initiate atherosclerotic lesion formation. The proposed research aimed …
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Inhibiting platelet scramblase activity
… two distinct populations of activated platelets form, pro-aggregatory and pro-coagulant platelets. Pro-aggregatory platelets have active integrins and aggregate together via fibrinogen to form the haemostatic plug which prevents bleeding. Pro-coagulant platelets expose …
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Novel blood platelet diagnostic platform
… platform to investigate the activation state of platelets. The final aim is to develop an assay to be used for diagnostic purposes. Blood platelets play a key role in the cardiovascular system. When the en- dothelium of the vessel wall is damaged platelets adhere and become activated, leading to …
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An investigation of the role of ACTN1 in platelet formation and of platelet function in myeloma
Platelet dysfunction may be inherited or acquired. In this study platelet dysfunction was assessed in both contexts; the inherited platelet disorder ACTN1-related Congenital Macrothrombocytopenia (CMTP) and the acquired prothrombotic state in Multiple Myeloma (MM). Actinin-1 is a widely-expressed …
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ANTIMICROBIAL PROPERTIES OF PLATELET-RICH PLASMA
Autologous platelet concentrates have been widely used in various medical fields in order to promote tissue regeneration. The significance behind their use lies in the presence of growth factors in platelets α-granules that enhance wound healing by promoting cell chemotaxis, proliferation and …
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Mandibular reconstruction: platelet rich plasma & scaffolds.
Contains fulltext : 19540_mandire.pdf (Publisher’s version ) (Open Access)
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Platelet surface receptors and melanoma metastasis
Ziel dieser Arbeit war es, die Rollen der Plättchen-Rezeptoren GPVI und GPIbα bei der hämatogenen Melanom-Metastasierung zu untersuchen. Die letzten Jahrzehnte haben zunehmend Indizien für eine Beteiligung von Plättchen und Plättchen-Rezeptoren bei der hämatogenen Tumor-Metastasierung geliefert. …
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Platelet kinetics in health and disease
[Typescript]
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Optically Pumped Thin Platelet Semiconductor Lasers
Made available in DSpace on 2014-12-08T22:24:27Z (GMT). No. of bitstreams: 1 6901366.pdf: 2274020 bytes, checksum: 9865d7ce22e6949db23bd1719b4cd5fd (MD5) Previous issue date: 1968
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Longitudinal analysis of platelet count data
Platelet transfusions are critical in managing bleeding risks in patients with low platelet counts or dysfunctional platelets. This research explores the dynamics of platelet count levels. The primary aim is to understand when and why platelet products are failing, by investigating differences in …
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GAG inhibition of collagen-platelet interaction
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 1977
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
Platelets are involved in many processes ranging from fighting microbial infections and triggering inflammation to promoting tumor angiogenesis and metastasis. Nevertheless, the primary physiological function of platelets is to act as essential mediators in maintaining homeostasis of the …
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NOVEL REGULATORS OF GPVI-MEDIATED PLATELET ACTIVATION
Platelets are anucleate cells that are crucial mediators of hemostasis and thrombosis. Under physiological conditions, platelets are maintained in a quiescent state within the vasculature. Upon vascular injury, an essential receptor that initiates platelet activation upon interaction with …
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Novel Agonists and Antagonists of Platelet Receptors
Platelets are central for the primary haemostatis. The platelet has surface bound receptors that are vital for the platelet activation. One of these receptors, the purinergic ADP-activated G-protein coupled receptor (GPCR) P2Y12 is a key receptor for platelet activation, and thus for thrombus …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
Platelets orchestrate haemostasis through receptor-mediated adhesion, aggregation, and secretion. Platelet dysfunction can lead to bleeding and/or clotting disorders but is challenging to diagnose clinically. This thesis focuses on immune thrombocytopenia (ITP), a disorder marked by immune-mediated …
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