Global ETD Search
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Showing 1 to 10 of 10 for “"Plasmodium vivax"”.
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Genetic characteristics of Plasmodium vivax from Northern Mali
Introduction: The surprising presence of P. vivax in West Africa and their ability to infect a Duffy negative population is one more threat to public health. In order to contribute to malaria elimination efforts, there is a need to investigate the origin and characteristics of P. vivax population …
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Determinación del proteoma de la cepa VCG-1 de Plasmodium Vivax y caracterización de moléculas candidatas para su inclusión en el desarrollo de una vacuna
… de proteínas que utilizan los merozoitos de Plasmodium para invadir a su célula hospedera, representan una estrategia importante para desarrollar un método de control contra estos parásitos. A pesar de ello, la investigación básica en P. vivax está retrasada por su difícil propagación in …
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Estudio de interacciones hospedero-patógeno y proteína-proteína en Plasmodium Vivax : evaluación de las proteínas del cuello de optrias -2, -4 y -5 y del antígeno apical de membrana-1
… vectores más importantes a nivel mundial, donde Plasmodium vivax representa una de las especies más ampliamente distribuidas, afectando ~13.8 millones de personas por año. Pese a ello, el progreso aparentemente lento de la infección y los niveles bajos de parasitemia en el humano, comparados a lo …
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Investigating the structure-function relationships of Plasmodium Haem Detoxification Protein and Phosphatidylinositol 4-kinase
The human malaria parasite Plasmodium falciparum relies on proteins and protein-mediated processes to survive, replicate in the host and evade the host's immune response. This study focuses on two Plasmodium proteins: (i) Haem Detoxification Protein (HDP) which has been reported to catalyse …
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Análisis económico del requisito de actividad inventiva frente a invenciones IA
… inhibir una enzima clave para el crecimiento del Plasmodium vivax, (uno de los parásitos que causa malaria)1. Adam y Eve no son humanos. Ambas denominaciones se corresponden a Inteligencias Artificiales Débiles capaces de operar brazos robot y maquinaria de laboratorio desarrolladas por el Dr. …
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The Economics of Vivax Malaria Treatment
… treatment of infected individuals. In <i>Plasmodium vivax</i>, multiple relapse episodes can only be averted by treating the dormant liver stage of the parasite life cycle - a strategy known as radical cure. This thesis aims to investigate key factors determining treatment-seeking …
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Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs
… In humans, malaria can be caused by several Plasmodium species that include: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae and Plasmodium knowlesi. The natural product artemisinin is a sesquiterpene lactone with an endoperoxide bridge isolated from the Chinese …
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Development of novel chemical biology tools to probe malaria parasite physiology and aid in antimalarial drug discovery
… is posed by the widespread malaria parasite Plasmodium vivax, which, unlike P. falciparum, cannot be propagated in vitro, hindering research into parasite biology and drug target identification. P. vivax preferentially invades reticulocytes, which are impractical to obtain in continuous …
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Structure, function and inhibition of GcpE, FPPS and GGPPS: targeting isoprenoid biosynthesis for drug discovery
… acids, have good inhibition (Ki~1μM) against Plasmodium vivax GGPPS. Benzoic acid analogs have been synthesized and tested against PvGGPPS. Crystal structures of several lipophilic bisphosphonates as well as benzoic acid derivatives bound to PvGGPPS have been solved. The lipophilic …
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THE ABUNDANCE AND INFECTION STATUS OF ANOPHELES spp. MOSQUITOES AT THREE SITES IN LOUDOUN COUNTY, NORTHERN VIRGINIA
… were among US travellers and were attributed to Plasmodium falciparum. In August 2002, two cases of human malaria due to Plasmodium vivax were reported in Loudoun County, Northern Virginia. The Center for Disease Control and Prevention concluded that these cases were acquired locally. This was …