Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Plasmodium spp"”.
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Lipoic acid protein ligases in Plasmodium spp.
Protozoan parasites of the genus Plasmodium are the causative agent of malaria. The four human pathogenic species infect more than 500 million people each year, causing the death of at least 1 million people. The most severe form of human malaria is caused by P. falciparum, which is responsible for …
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Control and eradication of Plasmodium spp. in man
Typescript, etc.
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Infección de Anopheles SPP por Plasmodium SPP y su importancia en la transmisión de Malaria en comunidades indígenas del Amazonas colombiano
Introducción: La disribución de las especies de Plasmodium han variado en las comunidades del Amazonas Colombiano, siendo P. vivax y P. malariae las de mayor frecuencia. Esto se debe a factores ambientales (como el cambio climático) y sociales (desplazamiento de la población) los cuales han …
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Factores asociados al riesgo de infecciones únicas y mixtas de Plasmodium SP. en población con sintomatología en el trapecio amazónico
… con el riesgo de infecciones únicas y mixtas por Plasmodium spp. en los municipios de Leticia y Puerto Nariño. Metodología: Estudio observacional analítico transversal; base de datos con información secundaria, Análisis de factores sociodemográficos, clínicos y de vivienda relacionadas a …
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Drug discovery against malaria parasite: drug repositioning strategy
Malaria, caused by Plasmodium spp., causes ~1 million deaths each year and there are ever present problems due to drug resistance. In this work, I used drug-repositioning strategy with bisphosphonates to discover a lead that is active against malaria in vivo. The developmental procedures include, …
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High-throughput functionalization of the Toxoplasma kinome uncovers a novel regulator of invasion and egress
… chemotherapeutic targets in parasites like Plasmodium spp. and Toxoplasma gondii. To systematically examine the parasite kinome, we developed a high-throughput tagging (HiT) strategy to endogenously label protein kinases with an auxin-inducible degron and fluorophore. Hundreds of tagging …
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Interrogating Host-Parasite Dynamics During Plasmodium Liver Stage Infection
… and is caused by the apicomplexan parasite Plasmodium. Plasmodium spp. are transmitted by an Anopheles mosquito and require both host and vector to complete their life cycle. Once in the host, parasites travel to the liver and undergo an obligatory and asymptomatic liver stage. This elusive …
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Multidimensional profiling of the Toxoplasma gondii proteome
… persistent, and deadly human diseases malaria (Plasmodium spp.) and toxoplasmosis (Toxoplasma gondii), making the understanding of these parasite signaling pathways of global importance. Although components of secondary messenger signaling pathways are conserved among apicomplexans and higher …
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Analysing the role of Protein Disulphide Isomerase in Plasmodium and targeting function to block transmission
… for transmission blocking interventions in Plasmodium spp. Located on the surface of the male gamete and ookinete, previous studies have demonstrated that this protein is essential for successful malaria transmission. PDIs are chiefly implicated in changing the conformation of other proteins …
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Induction of Anopheles stephensi nitric oxide synthase by Plasmodium-derived factor(s)
Malaria parasite (Plasmodium spp.) infection in the mosquito Anopheles stephensi induces significant expression of A. stephensi nitric oxide synthase (AsNOS) in the midgut epithelium as early as 6 h post-infection and intermittently thereafter. This induction results in the synthesis of …
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Investigation of azithromycin analogues and proteasome-like inhibitors as quick-killing antimalarials
… caused by mosquito-borne parasites of the genus Plasmodium which were responsible for ~435,000 of deaths annually, with >90% caused by the deadliest species, P. falciparum. Over the last two decades, global implementation of vector control and artemisinin combination therapies have resulted in …
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Regulation of Toxoplasma Motility by Calcium-Dependent Protein Kinases
… <italic>Toxoplasma gondii</italic> and <italic>Plasmodium spp.</italic>, the etiological agents of toxoplasmosis and malaria, respectively. A common mechanism enables these parasites to penetrate biological barriers and invade host cells actively, through a process termed gliding motility. This …