Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Plasmodium falciparum malaria"”.
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Determining Plasmodium falciparum Malaria Transmission Networks Through Sequenom And Capillary Electrophoresis Genotyping
Declining malaria transmission leads to infection hotspots which need to be targeted to eliminate and eradicate malaria. The degree of parasite mixing in and around transmission foci is likely to impact the effectiveness of targeted interventions and should be considered when developing control …
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An investigation of the mechanisms of piperaquine resistance in Plasmodium falciparum malaria
Antimalarial drug resistance is an unrelenting obstacle to malaria control programs. In Southeast Asia (SEA), parasites have developed some degree of resistance to nearly every malaria drug currently available, with the most recent emergence to artemisinin combination therapies (ACTs). ACTs are the …
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The impact of common and rare human genetic variants on erythrocyte invasion by Plasmodium falciparum malaria parasites
Malaria still remains a leading cause of mortality in several countries, particularly in sub-Saharan Africa. The African population is genetically diverse, and some people carry natural variants that confer varying levels of protection against the disease. In recent years, several large-scale …
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Biophysical properties of blood-stage Plasmodium falciparum malaria: from single-cell host-pathogen interactions to human protective polymorphisms
Malaria is a mosquito-borne infectious disease responsible for half a million deaths every year and long-term economic stagnation in many countries where it is endemic. All symptoms and pathology of malaria are caused by Plasmodium falciparum parasite, and are initiated when parasites invade human …
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Adaptation strategies to climate change in the Tropics: analysis of two multifactorial systems (high-altitude Andean ecosystems and Plasmodium falciparum malaria infections)
… and (ii) mosquito-borne diseases, focusing on Plasmodium falciparum malaria infections. My research on páramo ecosystems follows a six-tiered approach to understand the linkages between the ongoing changes in climatic conditions and the disruptions affecting the integrity of high-altitude …
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A study of the antimalarial action of Pyronaridine and its accumulation into Plasmodium falciparum
… drugs to treat chloroquine-resistant (CQR) Plasmodium falciparum malaria.
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An investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana
… reflects selective advantage against death from Plasmodium falciparum malaria. The most common type of alpha+-thalassaemia amongst people of African descent is the -α3.7 deletional type and affects 26-33% of Ghanaians. Plasmodium falciparum malaria is a major cause of mortality amongst children …
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Piperaquine - Bioanalys, drug metabolism and pharmacokinetics
Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. Piperaquine replaced chloroquine as the first line treatment in China for Plasmodium …
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Study of genetic modifiers of fetal hemoglobin and mechanisms of hydroxyurea-induced γ-globin expression in sickle cell disease
… has been amplified by the partial resistance to Plasmodium falciparum malaria, which is endemic along tropical equatorial Africa. Several genetic variants have since been associated with fetal hemoglobin (HbF), the disease-ameliorating globin protein, including variants at three principal loci; …
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Computational approaches to understanding infectious disease
… (2) study of the physiological state of the Plasmodium falciparum malaria parasite when sequestered in human tissue; (3) identifying the similarity and differences of the response to five anti-viral vaccines. To achieve the scientific goals of these projects I developed two new computational …
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Development of a plant-based vaccine against malaria
Malaria is the most prevalent tropical human disease reported worldwide, caused by protozoan parasites. Half of the world's population is at risk of malaria, and more than 200 million new cases are reported annually. Currently, there are no licensed vaccines available for use. Therefore, there is a …
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Efficacy of sulfadoxine-pyrimethamine with and without artesunate for the treatment of uncomplicated malaria in Mozambique : a randomised controlled trial
[Background and rationale] Malaria accounts for a large public health burden in Mozambique and a treatment policy with effective anti-malarials is a key component of their malaria control programme. Artemisinin-based combination therapies (ACTs) are now generally considered as the best treatment …
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Dynamic behavior of healthy and malaria infected human red blood cells
… as a manifestation of diseases such as malaria, spherocytosis, elliptocytosis and sickle cell anemia. However, much of this previous work has modeled the RBC membrane as a purely elastic material and experiments are typically performed within the quasistatic deformation regime. This work …
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Disease Surveillance and Implications on Public Health Decisions: Example of invasive Salmonellosis in sub-Saharan Africa
… relationships with other pathogens (i.e., *Plasmodium falciparum* malaria and COVID-19), and eventually disaggregates the use of surveillance and obtained data for public health decision making to use TCV and upcoming iNTS vaccines in endemic settings. The research presented here relies …
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Modelling gametocytes in the presence of interval-censoring
Malaria is a parasitic disease that has afflicted many over the years, with Plasmodium falciparum malaria accounting for many deaths. Gametocytes are the sexual form of the parasite responsible for transmitting and spreading malaria from the human host to the mosquito vector. Most studies are …
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Large–scale data–driven network analysis of human–plasmodium falciparum interactome: extracting essential targets and processes for malaria drug discovery
Background: Plasmodium falciparum malaria is an infectious disease considered to have great impact on public health due to its associated high mortality rates especially in sub Saharan Africa. Falciparum drugresistant strains, notably, to chloroquine and sulfadoxine-pyrimethamine in Africa is …
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Joint models for nonlinear longitudinal profiles in the presence of informative censoring
Malaria is the parasitic disease which affects the most humans, with Plasmodium falciparum malaria being responsible for the majority of severe malaria and malaria related deaths. The asexual form of the parasite causes the signs and symptoms associated with malaria infection. The sexual form of …
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Functional Characterization of Serine Hydrolases Mediating Lipid Metabolism and Protein Depalmitoylation in Asexual Stage Plasmodium Falciparum
Malaria is an infectious disease caused by Plasmodium parasites and transferred by Anopheles mosquitos. Due to Artemisinin resistance, new druggable targets identification and new drug development are urgently needed. Serine hydrolases (SHs) are one of the largest classes of enzymes having …
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Investigating the role of the Apicoplast in Plasmodium falciparum Gametocyte Stages
Malaria continues to be a global health burden that affects millions of people worldwide each year. Increasing demand for malaria control and eradication has led research to focus on sexual development of the malaria parasite. Sexual development is initiated when pre-destined intraerythrocytic ring …
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Estudo de modelagem molecular de derivados de desoxiuridina como inibidores da dUTPase de Plasmodium falciparum.
Malaria is a parasitic disease that continues to b e responsible for a huge number of deaths around the world. The disease is p resent in 99 countries with the alarming number of deaths per year reaching 655,000 ; about 3.3 billion people are at risk areas. Among the agents that cause malaria, …
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