Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 296 for “"Plasmodium falciparum"”.
-
Glutathione metabolism of Plasmodium falciparum
Apicomplexan parasites of the genus Plasmodium are the causative agent of malaria, one of the most prevalent infectious diseases worldwide. Five different Plasmodium species can cause malaria in humans, leading to a total of approximately 500 million cases each year and of these, P. falciparum …
-
Plasmodium falciparum protein kinase CK2
… intracellular protozoan parasites of the genus Plasmodium, is responsible for 300 to 600 million clinical cases annually (Snow et al., 2005), resulting in the deaths of up to three million people every year (Breman, 2001, Breman et al., 2004). There is a clear need for further research aimed at …
-
Purine transport in plasmodium falciparum
… rates of transport of radiolabeled purines into Plasmodium falciparum-infected erythrocytes were measured using classical uptake techniques. We found that the uptake of purine into intact parasite-infected erythrocytes was mediated by the endogenous human erythrocyte nucleoside and nucleobase …
-
Characterisation of Mefloquine accumulation in Plasmodium falciparum
… very little is known about its interaction with Plasmodium falciparum. In 1979, Fitch er al carried out the only other published extensive investigation of mefloquine accumulation, but were not able to demonstrate energy dependent uptake. They later indicated that an energy requirement may be …
-
Purification and characterisation of plasmodium falciparum Hypoxanthine phosphoribosyltransferase
… by the emrggence of drug resistant strains of Plasmodium falciparum. The work reported in this thesis focuses on improving the purification of PfHPRT by investigating the characteristics of anion exchange DE-52 chromatography (the first stage of purification), developing an HPLC gel filtration …
-
Gene expression profiling of polyamine-depleted Plasmodium falciparum
… biosynthesis as well as schizogony arrest in P. falciparum. However, they did not elaborate on any other consequences that polyamine depletion could exert on the parasite. This dissertation aims to elucidate the significance of the inhibition of polyamine biosynthesis within P. falciparum by …
-
Functional analyses of Plasmodium Falciparum primary metabolic genes
… and kinetic characterization of P. falciparum isocitrate dehydrogenase, malate dehydrogenase and pyruvate kinase. And, since RT-PCR showed that all the 10 ORFs were actively transcribed during infection, analyses of web-based microarray data were done. These further supported the …
-
Pharmacological effect of MEK inhibitors on plasmodium falciparum
… is engaged in research aiming at characterising Plasmodium protein kinases at the biochemical and functional levels, with emphasis on homologues of enzymes that are known regulators of proliferation and differentiation in eukaryotic cells. The Mitogen Activated Protein Kinases (MAPKs) are …
-
Investigating the ubiquitin conjugating machinery in *Plasmodium falciparum*
*Plasmodium falciparum* is the causative agent of the most lethal form of human malaria. In the absence of a vaccine and the emergence of drug-resistant parasites, novel targets against malaria are required. The ubiquitin-proteasome system (UPS), which involves the attachment of the small protein …
-
Chloroquine accumulation in Plasmodium falciparum isolated digestive vacuoles
Due to the development of drug-resistance by Plasmodium falciparum, the utilisation of chloroquine, a cheap and effective antimalarial has become limited. The mechanism of chloroquine-resistance is, at best, unresolved. This thesis describes an investigation of chloroquine accumulation in pure and …
-
Deformability of Plasmodium falciparum parasitized red blood cells
… altered RBC deformability caused by invading Plasmodium falciparum parasites, which are responsible for the disease malaria, is evaluated. P. falciparum parasitized RBCs (pRBCs) display decreased deformability and novel cytoadherence properties, and sequester in the microcirculation. …
-
Characterisation of the plasmodium falciparum HSP70-HSP90 organising protein
Malaria is caused by Plasmodium falciparum (P. falciparum) parasite and accounts for approximately more than half a million deaths yearly. P. falciparum survives under various physiological conditions during its life cycle. The parasite employs its molecular chaperones machinery particularly heat …
-
Expression & Purification of Recombinant Plasmodium falciparum Erythrocyte-binding Ligands
Plasmodium falciparum, the most virulent malarial parasite, is capable of invading all known human blood types. Erythrocyte invasion depends on specific parasite ligand and erythrocyte receptor interactions. These interactions are mediated by Region II of the P. falciparum erythrocyte binding …
-
Proteomic Analysis Delineates the Signaling Networks of Plasmodium falciparum
Malaria is a life-threatening disease caused by Plasmodium parasites that are spread through the bites of infected mosquito vectors. It is a worldwide pandemic that threatens 3.4 billion people annually. Currently, there are only a few validated Plasmodium drug targets, while drug resistance …
-
Factors affecting Plasmodium falciparum sporozoite formation in Anopheles mosquitoes
… numbers from two genetically different Plasmodium falciparum clones (3D7 and HB3) in Anopheles gambiae mosquitoes, and the pattern of inheritance of the phenotype was investigated. Membrane-feeding of cultured P. falciparum parasites to laboratory-reared Anopheles mosquitoes produced …
-
The characterization of adaptor protein homologues in Plasmodium falciparum
Plasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets. Components of the endocytic and secretory pathway in asexual stage parasites are attractive targets because they play a fundamental …
-
Engineered tools for studying the malaria parasite plasmodium falciparum
… be designed to study the basic biology within Plasmodium falciparum and characteristics of the pathological relationship between host and parasite. These tools will be diverse in nature, yet all seek to address the same fundamental question: what are the characteristics of the parasite that can …
-
Evaluation of the immunomodulatory activity of Plasmodium falciparum hsp70-1
… chaperone system (protein folding machinery). Plasmodium falciparum Hsps play an important cytoprotective role ensuring that the malaria parasite survives under the harsh conditions that prevail in the host environment. P. falciparum Hsp70-1 (PfHsp70-1) is a ubiquitous, cytosol-localised Hsp70 …
-
On the Oxidative Half-Reaction of Plasmodium Falciparum Dihydroorotate Dehydogenase
Plasmodium falciparum is the parasite responsible for an estimated 500 million malaria cases per year, which result in 1-2 million annual deaths. Current antimalarial chemotherapies are met with the tremendous ability of the parasite to develop resistance, underscoring the need for newer, more …
Page 1 of 15