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Showing 1 to 20 of 415 for “"Plasmodium"”.
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Glutathione metabolism of Plasmodium falciparum
Apicomplexan parasites of the genus Plasmodium are the causative agent of malaria, one of the most prevalent infectious diseases worldwide. Five different Plasmodium species can cause malaria in humans, leading to a total of approximately 500 million cases each year and of these, P. falciparum …
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Plasmodium falciparum protein kinase CK2
… intracellular protozoan parasites of the genus Plasmodium, is responsible for 300 to 600 million clinical cases annually (Snow et al., 2005), resulting in the deaths of up to three million people every year (Breman, 2001, Breman et al., 2004). There is a clear need for further research aimed at …
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Purine transport in plasmodium falciparum
… rates of transport of radiolabeled purines into Plasmodium falciparum-infected erythrocytes were measured using classical uptake techniques. We found that the uptake of purine into intact parasite-infected erythrocytes was mediated by the endogenous human erythrocyte nucleoside and nucleobase …
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Molekulare Mechanismen der Plasmodium-Anopheles Interaktionen
… die sich mit den molekularen Mechanismen der Plasmodium-Anopheles Interaktionen beschäftigen. 1. Die melanotische Einkapselung von Plasmodium-Parasiten im Mitteldarm der Anopheles gambiae Mücke stellt eine effiziente Immunantwort dar, die den Lebenszyklus des Malaria-Erregers unterbrechen …
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Defense mechanisms against Plasmodium berghei in mice
Contains fulltext : mmubn000001_007497008.pdf (Publisher’s version ) (Open Access)
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Lipoic acid protein ligases in Plasmodium spp.
Protozoan parasites of the genus Plasmodium are the causative agent of malaria. The four human pathogenic species infect more than 500 million people each year, causing the death of at least 1 million people. The most severe form of human malaria is caused by P. falciparum, which is responsible for …
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Plasmodium Gallinaceum in Vivo and in Vitro
The findings presented in this dissertation provide a more solid foundation for the comparison of avian malaria with falciparum malaria, and strengthen the rationale upon which to base development of attenuated live sporozoite vaccines for falciparum malaria.
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Characterisation of Mefloquine accumulation in Plasmodium falciparum
… very little is known about its interaction with Plasmodium falciparum. In 1979, Fitch er al carried out the only other published extensive investigation of mefloquine accumulation, but were not able to demonstrate energy dependent uptake. They later indicated that an energy requirement may be …
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Control and eradication of Plasmodium spp. in man
Typescript, etc.
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Purification and characterisation of plasmodium falciparum Hypoxanthine phosphoribosyltransferase
… by the emrggence of drug resistant strains of Plasmodium falciparum. The work reported in this thesis focuses on improving the purification of PfHPRT by investigating the characteristics of anion exchange DE-52 chromatography (the first stage of purification), developing an HPLC gel filtration …
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Gene expression profiling of polyamine-depleted Plasmodium falciparum
Polyamines play an important role in DNA, RNA and protein synthesis as well as a variety of other biological processes (cell division, differentiation and death) as outlined in Chapter 1. Assaraf and co-workers (1984) demonstrated that treatment with DFMO resulted in the inhibition of polyamine …
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Functional analyses of Plasmodium Falciparum primary metabolic genes
Exploitation of plasmodial genes as drug-targets is important but their primary metabolic genes have been neglected and widely thought to be cryptic. However, datamining the plasmodial genome revealed DNA sequences that potentially support a network of glycolytic and TCA pathways. To question the …
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Pharmacological effect of MEK inhibitors on plasmodium falciparum
… is engaged in research aiming at characterising Plasmodium protein kinases at the biochemical and functional levels, with emphasis on homologues of enzymes that are known regulators of proliferation and differentiation in eukaryotic cells. The Mitogen Activated Protein Kinases (MAPKs) are …
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Innovative formulations for the treatment of Plasmodium infections
Nanomedicine is one of the most innovative strategies to target drugs at the action site and increase their activity index. Phytomedicine is the most traditional method used to treat human diseases and solve health problems. Their combination represents the future prospective to a better care of …
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Studies of Clonal Populations of Nk65 Plasmodium Berghei
Made available in DSpace on 2014-12-14T16:11:15Z (GMT). No. of bitstreams: 1 7820904.pdf: 5529905 bytes, checksum: f9ee55555c529e1be3144561415c062c (MD5) Previous issue date: 1978
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Characterisation of Plasmodium parasite sexual commitment and development
… caused by a single-celled parasite of the genus Plasmodium, which establishes infection via a bite from an Anopheline mosquito. While the parasite progresses through a complex range of life stages, it is the blood stages, or the intraerythrocytic developmental cycle (IDC), that cause the large …
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Investigating the ubiquitin conjugating machinery in *Plasmodium falciparum*
*Plasmodium falciparum* is the causative agent of the most lethal form of human malaria. In the absence of a vaccine and the emergence of drug-resistant parasites, novel targets against malaria are required. The ubiquitin-proteasome system (UPS), which involves the attachment of the small protein …
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Genetic characteristics of Plasmodium vivax from Northern Mali
Introduction: The surprising presence of P. vivax in West Africa and their ability to infect a Duffy negative population is one more threat to public health. In order to contribute to malaria elimination efforts, there is a need to investigate the origin and characteristics of P. vivax population …
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Chloroquine accumulation in Plasmodium falciparum isolated digestive vacuoles
Due to the development of drug-resistance by Plasmodium falciparum, the utilisation of chloroquine, a cheap and effective antimalarial has become limited. The mechanism of chloroquine-resistance is, at best, unresolved. This thesis describes an investigation of chloroquine accumulation in pure and …
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Deformability of Plasmodium falciparum parasitized red blood cells
… altered RBC deformability caused by invading Plasmodium falciparum parasites, which are responsible for the disease malaria, is evaluated. P. falciparum parasitized RBCs (pRBCs) display decreased deformability and novel cytoadherence properties, and sequester in the microcirculation. …
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