Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 117 for “"Plasminogen"”.
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Role of Plasminogen and Urokinase-Type Plasminogen Activator in Cardiac Mesenchymal Cell Migration In Vitro
Studies show that urokinase-type plasminogen activator (uPA) conversion of plasminogen into plasmin is an important mediator of cell migration. In the developing chick heart, uPA has been implicated as a mediator of atrioventricular (AV) cushion cell migration, however the role of the …
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Soluble urokinase plasminogen activator receptor in venous ulcers
… give rise to better treatments.<br/>Urokinsae plasminogen activator receptor (uPAR), a GPI anchored 3‐domain<br/>protein exists either attached to cell wall or in soluble forms (suPARI‐III, suPARI<br/>& suPARII‐III fragments). Cleavage of uPAR results in a number of nonproteolytic<br/>functions …
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Analysis of plasminogen binding to Treponema denticola, a key periopathogen
… binding proteins have been shown to bind plasminogen. Plasminogen is a plasma glycoprotein that circulates as a zymogen. Its active form, plasmin, degrades components of the extracellular matrix and cleaves complement proteins C3b and C5 inhibiting complement pathway progression. Through …
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The distribution of plasminogen activator in the male genital tract
The blood of man is rich in plasminogen, the inactive precursor of plasmin, a protease (Astrup, 1956a); the most characteristic action of plasmin is the digestion of fibrin, i.e. fibrinolysis. Many tissues, including the prostate (Rasmussen and Albrechtsen, 1960a), contain substances which can …
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Generation of novel small molecules as inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor (PAI-1) is a member of the serine protease inhibitor (serpin) family of proteins, which inhibits certain serine proteases, such as tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and thus is a primary regulator of …
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The Role of The Plasminogen-Fibrin Interaction in The Regulation of Fibrinolysis
… The major components of the fibrinolytic system, plasminogen and plasminogen activator, are known to co-exist in the blood but the biochemical details of how the proteolytic system is regulated to restrict plasmin formation to the sites of fibrin clots are not well understood. A possible mechanism …
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Characterization of a plasminogen activator from human melanoma cells cultured in vitro
… done on the isolation and characterization of a plasminogen activator, Mel-PA, that is released by human melanoma cells cultured in vitro. This enzyme was compared to the urinary plasminogen activator, urokinase. The human melanoma cell line, RPMI-7272, (also referred to as the "Bowes" melanoma …
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In vivo and in vitro regulation of plasminogen activator inhibitor type-1
… switch from producing a mixture of active tissue plasminogen activator (t-PA) and urokinase (u-PA) to producing active u-PA alone. I performed a series of experiments designed to examine the mechanism of down regulation of t-PA activity that occurred with differentiation. The results of these …
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Design, synthesis and evaluation of small molecules as inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. Excessive levels of PAI-1 inhibit urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA), which regulates fibrinolysis as well as the development of …
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Insights Into the Dynamic Structure and Inhibitory Mechanism of Plasminogen Activator Inhibitor Type 1
The aim of this study was to delineate the biochemical differences between wild-type PAI-1 (wtPAI-1) and 14-1B and to infer structural and functional details about the naturally occurring inhibitor using the structural model of the stable variant as a starting point. Using …
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Molecular Insights and Physiological Consequences of Aryl Hydrocarbon Receptor Regulated Plasminogen Activator Inhibitor-1 Expression
… for suppression of the regenerative response is plasminogen activator inhibitor-1 (PAI-1), which negatively regulates the cleavage and activation of hepatocyte growth factor (HGF) from its latent form in the extracellular matrix. Once activated, HGF signalling through its receptor cMet is a …
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Blood-Derived Plasminogen Modulates the Neuroimmune Response in Both Alzheimer's Disease and Systemic Infection Models
… characteristic of AD are not fully understood. Plasminogen is primarily a blood protein synthesized in the liver, which when cleaved into its active form, plasmin, plays roles in fibrinolysis, wound healing, cell signaling, and inflammatory regulation. Increasing evidence links plasminogen to …
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PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles
… of mRNA and protein for the tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA) and their inhibitor PAI-1 was measured in granulosa cells. uPA and PAI-1 mRNAs peaked 12 hours and 36 hours after hCG administration respectively. tPA mRNA decreased 36 hours …
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Progress toward a structure-function relationship for novel, small-molecule inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor-1 (PAI-1) is a serpin protein whose function is to inhibit tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and hence, fibrinolysis. This inhibition leads to decreased plasminogen to plasmin conversion, which results in …
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Synthesis and structure activity relationship of novel small molecules as inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) family. PAI-1 is involved in the regulation of fibrinolysis, which is the breakdown of blood clots. PAI-1 inhibits serine proteases tissue-type plasminogen activator (tPA) and urokinase-type …
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Purification and Characterization of the Plasminogen Activator From the Human Neuroblastoma Cell Line, Sk-N-Sh
The plasminogen activator produced by the human neuroblastoma cell line, SK-N-SH, has been purified and its enzymatic, immunological, and physical properties have been characterized and compared to the properties of human urokinase. The purification scheme involves concentration of the SK-N-SH
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… the potential of targeting the urokinase plasminogen activator (uPA) system, a well-documented factor in cancer progression as a therapeutic strategy in PDAC management, particularly in conjunction with the chemotherapeutic agent, Gemcitabine. Using publicly available datasets, we first …
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