Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Plasmin"”.
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Proteases of the neutrophil membrane represent an alternative fibrinolytic pathway to that mediated by plasmin
… degradation was distinct from that produced by plasmin, neutrophil lysosomal enzymes and purified human neutrophil elastase and enhanced the action of plasmin in clot solubilization. Preincubation of neutrophils with monoclonal antibodies directed against the CD 11 c/CD 18 integrin was able to …
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PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles
… of mRNA and protein for the tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA) and their inhibitor PAI-1 was measured in granulosa cells. uPA and PAI-1 mRNAs peaked 12 hours and 36 hours after hCG administration respectively. tPA mRNA decreased 36 hours …
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Role of Plasminogen and Urokinase-Type Plasminogen Activator in Cardiac Mesenchymal Cell Migration In Vitro
Studies show that urokinase-type plasminogen activator (uPA) conversion of plasminogen into plasmin is an important mediator of cell migration. In the developing chick heart, uPA has been implicated as a mediator of atrioventricular (AV) cushion cell migration, however the role of the …
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The Role of The Plasminogen-Fibrin Interaction in The Regulation of Fibrinolysis
… The major components of the fibrinolytic system, plasminogen and plasminogen activator, are known to co-exist in the blood but the biochemical details of how the proteolytic system is regulated to restrict plasmin formation to the sites of fibrin clots are not well understood. A possible mechanism …
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Role of Thrombin-Activatable Fibrinolysis Inhibitor in Breast Cancer Metastasis and Angiogenesis
… cell migration and invasion. Proteases such as plasmin and matrix metalloproteinases are responsible for degradation of the extracellular matrix, facilitating cancer cell invasion and subsequent metastasis. These proteases are also important in promoting tumour angiogenesis. Therefore, …
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Blood-Derived Plasminogen Modulates the Neuroimmune Response in Both Alzheimer's Disease and Systemic Infection Models
… characteristic of AD are not fully understood. Plasminogen is primarily a blood protein synthesized in the liver, which when cleaved into its active form, plasmin, plays roles in fibrinolysis, wound healing, cell signaling, and inflammatory regulation. Increasing evidence links plasminogen to …
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The principal protease system in bovine milk
Plasmin is the principal endogenous protease in bovine milk. Distribution of overall proteolytic potential among milk fractions was determined using Coumarin Substrate as a synthetic substrate. Casein containing fractions had a higher amidolytic potential. However, preparation of casein by acid …
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The distribution of plasminogen activator in the male genital tract
The blood of man is rich in plasminogen, the inactive precursor of plasmin, a protease (Astrup, 1956a); the most characteristic action of plasmin is the digestion of fibrin, i.e. fibrinolysis. Many tissues, including the prostate (Rasmussen and Albrechtsen, 1960a), contain substances which can …
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Primary proteolysis of caseins in cheddar cheese
… chymosin on bovine αs1- and αs2-caseins and of plasmin on bovine αs1-casein were determined. The action of cathepsin D, the principal indigenous acid milk proteinase, on caseins was studied and its pH optimum and sensitivity to NaCI determined. The action of cathepsin D on αs1-, αs2-, β- and …
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Effect of high heat treatment and β-casein-reduction on the rennet coagulation and ripening of Cheddar and Emmental cheeses manufactured from micellar casein concentrate
… removing whey protein from milk increased the plasmin activity of the cheesemilk formulated therefrom and also increased the level of primary proteolysis (as measured by urea-PAGE and HPLC) in the resultant Emmental cheeses. Increasing the casein content in cheesemilk led to an increased gel …
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Analysis of plasminogen binding to Treponema denticola, a key periopathogen
… binding proteins have been shown to bind plasminogen. Plasminogen is a plasma glycoprotein that circulates as a zymogen. Its active form, plasmin, degrades components of the extracellular matrix and cleaves complement proteins C3b and C5 inhibiting complement pathway progression. Through …
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Studies of Coagulation and Fibrinolysis
… were studied. In addition, the kinetics of plasmin-mediated fibrin degredation were determined. First, the mechanism of prothrombin activation by prothrombinase was investigated using two models – a one-form model which posits a single form of prothrombinase and a two-form model which posits …
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Proteolysis of mammary secretion proteins during involution of bovine mammary gland
… and peptides during involution, (b) to measure plasmin, plasminogen and plasminogen activator activity in mammary secretions collected during involution, and (c) to identify and characterize milk protein derived-peptides in mammary secretions during involution. Proteins in mammary gland …
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The D-domain of fibrin : structural and functional studies
… (ogen) was separated from the parent molecule by plasmin digestion in the presence of calcium and isolated by means of DEAE-anion exchange chromatography followed by gel-filtration in buffer containing 4 M urea. Fluorescent-D-dimer (f-D-dimer) was isolated from a plasmic digest of fibrin clotted …
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Synthetic, Sulfated, Lignin-Based Anticoagulants
… SbO4L is a selective inhibitor of thrombin and plasmin. SbO4L was found to act via a unique mechanism targeting thrombin exosite 2 in a manner similar to platelet glycoprotein Ibα (GPIbα). Advanced hemostasis and thrombosis assays demonstrated that SbO4L acts via a dual mechanism: as an …
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Synthesis and biological evaluation of structurally diverse indole-based analogues as inhibitors of tubulin polymerization and synthesis of drug-linker constructs cleavable by enzymes present in the tumor microenvironment.
… extracellular proteases, such as urokinase-type plasminogen activator (uPA) or plasmin, that are upregulated or activated in the tumor microenvironment. We have incorporated plasmin-targeted (D-Ile-L-Phe-L-Lys) and uPA-targeted (Gly-Gly-L-Arg) short peptide sequences within the constructs bearing …
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Metals and the conformation of fibrin
… (Factor XIIIa) catalysed crosslinked plasmin derived D-dimer into apparently symmetrical monomers has been described. The activity is fibrin specific and displays an unusual site specificity for the γ-carboxy terminal domains within the crosslink region. The activity was reported to be …
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Progress toward a structure-function relationship for novel, small-molecule inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor-1 (PAI-1) is a serpin protein whose function is to inhibit tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and hence, fibrinolysis. This inhibition leads to decreased plasminogen to plasmin conversion, which results in …
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Chemical and physical properties of bovine alpha-lactalbumin, beta-casein and genetically altered bovine beta-casein produced in the milk of transgenic mice
… In addition, two chymosin-resistant and one plasmin-resistant bovine $\beta$-casein genomic constructs were generated and microinjected to generate transgenic mice. Mouse milk containing each of the three mutant $\beta$-caseins was produced and analyzed by immunoblotting with a bovine …
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The Role of Tumor Necrosis Factor-Stimulated Gene 6 Protein (TSG-6) in Osteoarthritis
… absence of inter-alpha-inhibitor (IαI), on anti-plasmin activity, evaluated for the in vivo presence of heavy chains (HCs) in cartilage matrix (evidence of TSG-6 activity), evaluated the gene expression of IαI components and TSG-6 in cartilage, and explored effects of TSG-6 on matrix assembly in …
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