Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Plasmacytoid"”.
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… production of pathogenic autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus (SLE), a prototypic systemic humoral autoimmune disease. However, the cellular events that …
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Plasmacytoid dendritic cells & immunotherapy of cancer
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Plasmacytoid dendritic cells and neutrophils : underestimated cell populations during the onset of atherosclerosis
… the pathophysiological role of neutrophils and plasmacytoid dendritic cells in atherosclerosis. Atherosclerosis is now agreed to be a chronic inflammatory disease of the vessel wall driven by intense immunological activity, of both, innate and adaptive immunity. Whereas monocytes/macrophages are …
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Plasmacytoid Dendritic Cells Sense Skin Injury and Promote Wound Healing Through Type I Interferons
Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells, which selectively express intracellular Toll-like receptors (TLR)-7 and TLR-9 and have the capacity to produce large amounts of type I IFNs (IFN-a/b) in response to viruses or host derived nucleic acid containing …
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Studies on the Interaction between Porcine Plasmacytoid Dendritic Cells and Porcine Reproductive and Respiratory Syndrome Virus
… production in response to a viral infection, the plasmacytoid dendritic cell (PDC), had been largely ignored. Conceivably, this dismissal was based on the fact that a subset of AM is the principal target cell of PRRSV and that these cells readily support its replication in vitro. Because of the …
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Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
… response was not dependent on the presence of plasmacytoid dendritic cells (pDCs), suggesting monocytes as the possible source of the interferon response. In the last study, we examined the responses of plasmacytoid dendritic cells (pDCs) to HIV and other stimuli in healthy and HIV-infected …
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Immune Recognition of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity
… the dendritic cells (DCs). However, in psoriasis plasmacytoid dendritic cells have been found to be able to sense self-DNA molecules in complex with the endogenous cationic antimicrobial peptide LL37, which are internalized into the endosomal compartments and thus can access TLR9. We investigated …
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ΕΠΙΔΡΑΣΗ ΤΟΥ ΦΟΡΒΟΛΙΚΟΥ ΕΣΤΕΡΑ ΤΡΑ ΣΕ ΑΝΘΡΩΠΙΝΑ ΛΕΥΧΑΙΜΙΚΑ ΛΕΜΦΟΚΥΤΤΑΡΑ
… (60-70% OF THE CELL POPULATION) OR OF PLASMACYTOID OR PLASMA CELLS (THE REMAINING CELLS. IT HAS BEEN FOUND THAT TPA, AT THE CONCENTRATION OF 16NM, INDUCED, IN BOTH CELL LINES, PHENOTYPIC AND FUNCTIONAL CHANGES,INDICATING DIFFERENTIATION OF THE CELLS TOWARDS MORE MATURE STAGES. …
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ΔΙΑΤΑΡΑΧΕΣ ΤΩΝ ΑΝΟΣΟΣΦΑΙΡΙΝΩΝ ΣΤΑ ΚΑΚΟΗΘΗ ΜΗ HODGKIN'S ΛΕΜΦΩΜΑΤΑ ΑΠΟ Β ΚΥΤΤΑΡΑ
… 40%, SMALL LYMPHOCYTIC LYMPHOMA (SLL) 41,6% AND PLASMACYTOID LYMPHOCYTIC LYMPHOMA 58,3%. HYPOGAMMAGLOBULINAEMIA WAS MORE FREQUENT IN CLL AND SLL. BENCE-JONES PROTEINS WAS FOUND IN 5 CASES. HIGH TITRE AUTOANTIBODIES WERE FOUND IN 4 PATIENTS WITH MONOCLONAL IMMUNOGLOBULINS.
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ΒΛΕΝΝΟΓΟΝΙΚΑ ΛΕΜΦΩΜΑΤΑ. ΜΕΙΖΟΝΕΣ ΛΕΜΦΟΥΠΕΡΠΛΑΣΤΙΚΕΣ ΑΛΛΟΙΩΣΕΙΣ ΤΟΥ ΣΤΟΜΑΧΟΥ ΑΠΟ ΜΟΡΦΟΛΟΓΙΚΗ ΚΥΡΙΩΣ ΑΠΟΨΗ. ΝΕΩΤΕΡΕΣ ΑΝΤΙΛΗΨΕΙΣ
… A PERCENTAGE OF AROUND 21% IN EACH ONE OF THEM. PLASMACYTOID "DIFFERENTIATION" IN 13% OF NHL,S AND FOCAL POLYMORPHISM IN 30% WERE FOUND. REED-STERNBERG TYPE CELLS WERE ENCOUNTERED IN 3 OUTOF 47 CASES OF LYMPHOMAS, ONLY. NO EARLY INVOLVEMENT OF THE WALDEYER'S RING LYMPHOID TISSUE WAS FOUND. NO …
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The Biology of Dendritic Cells in the Context of Autoimmunity
… and flares is poorly understood. Because plasmacytoid dendritic cells (pDCs) are the primary type I IFN producers, their role in SLE has long been suspected, with murine pDC depletion models successfully delaying the progression of murine lupus-like disease. However, the mechanism behind …
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Insights into the Iimmune Mechanisms Leading to Lupus-like Autoimmunity in New Zealand Black Mice
… Polyclonal B cell activation, expansion of plasmacytoid dendritic cells (pDC), and elevated gene expression of baff were maintained in CD40L-deficient NZB mice, despite the lack of IgG immune complexes. Chapter 3 utilizes bicongenic mice carrying both NZB chromosomes 1 and 13 to investigate …
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Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer
… cross-presenting cDC1 at the expense of cDC2 and plasmacytoid DCs (pDC). Lastly, combination of PKC agonism with agonistic CD40 mAb, a form of innate immunotherapy, resulted in a reduction in tumor growth with a significant increase in intratumoral activated CD8+ T cells in a syngeneic breast …
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Immunotherapy in multiple myeloma
… The numbers of blood myeloid DC (BmDC) and blood plasmacytoid DC (BpDC) are low throughout the course of the disease, and only improve for a short period of time following autologous HSCT. Thalidomide therapy of patients with relapsed disease was associated with an increase in BmDC1 and BpDC …
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Targeting of specific developmental pathways to understand dendritic cell heterogeneity and function
… of these subsets are not well understood. Plasmacytoid dendritic cells (PDCs) are a subset of dendritic cells that are specialized at the secretion of type I interferon. Through conditional targeting of E2-2, a transcription factor essential for the specification of the PDC lineage, we have …
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The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells
… phenotype and do not produce type I IFN. Plasmacytoid DC (pDC) induce a strong type I IFN response to a viral infection, but not to the viral surface glycoproteins. In the context of natural HSV-1 infection, these results suggest a model in which at the site of HSV-1 infection, different …
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