Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Plasma proteins"”.
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Plasma proteins and cardiac oedema
… of cardiac oedema is a depletion of the plasma proteins which results in a fall in the colloid osmotic pressure of the blood. This depletion is due principally to malnutrition, and it is suggested that cases of cardiac oedema should be given diets containing the maximum amount of protein …
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Antimicrobial activity of human seminal plasma and seminal plasma proteins
Seminal plasma is semen without the spermatozoa. Human seminal plasma is a complex mixture of secretions from the sex accessory glands, mainly the seminal vesicles and the prostate. Seminal plasma has high protein content and it also contains ions, sugars and low molecular weight components. …
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Influence of plasma proteins on setting characteristics of mineral trioxide aggregate like cement
… and γ-globulin, the three most abundant blood plasma proteins, both individually and in combination on the setting time, compressive strength and relative porosity of an MTA-like dental cement. The cement powder formulation was mixed with the liquid phase containing normal plasma protein …
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Effects of plasma proteins on the sieving of macromolecular tracers in the kidney
The ultrafiltration of plasma in the mammalian glomerulus is the first step in the processing of blood by the kidney. Proper functioning of this process is critical to the kidney's ability to effectively eliminate waste and retain desirable substances. The glomerular barrier has long been regarded …
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A study of the binding of anti-aggregatory substances to platelet bound plasma proteins.
… of a number of platelet active ligands to plasma proteins studies were conducted with platelets. A number of methods for washing platelets were investigated in order to find an efficient and reproducible method of washing platelets. The binding of DPD to platelets was then studied using …
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Characterizing blood plasma proteins from organ tissue in rainbow trout (Oncorhynchus mykiss) using a non-targeted proteomics approach
… the rainbow trout proteome with a focus on blood plasma proteins. Blood, brain, heart, liver, kidney, and gills were collected from adult rainbow trout, plasma and tissue proteins were analyzed using liquid chromatography tandem mass spectrometry. Over 10,000 proteins were identified across all …
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Nanoscale properties of poly(ethylene terephthalate) vascular grafts
… in biomaterials. Due to surface forces, blood plasma proteins adsorb to the graft, resulting in inflammation, infection, thrombus formation, and ultimately, vessel reclosure. The object of this project was to characterize and analyze the nanoscale surface properties of three different …
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Factors Influencing the Formation and Distribution of Cholesterol Esters in Human Plasma
… and lipid transfer protein (LTP) reactions in plasma. These two plasma proteins play important roles in determining the formation and distribution of cholesterol esters in plasma.
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Morphological responses of neutrophils in suspension to plasma components and chemotactic factors / Damien Gerard Harkin.
… course and degree of neutrophil polarisation in plasma and compares this response with those induced by FMLP, purified plasma proteins (particularly immunoglobulin type G) and chemotactic imflammatory mediators. In addition, the possible roles of extracellular divalent cations (Ca2+ and Mg2+), …
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Impact of human blood plasma-derived protein corona on extracellular vesicle uptake
… EVs have been demonstrated to carry a range of proteins and nucleic acids subsequently delivered to recipient cells, making them attractive as drug delivery vehicles. Several mechanisms for the cellular uptake of EVs have been established. When a nanoparticle is introduced into blood plasma, …
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Elucidating the Impact of Endogenous Proteins on Lipid Nanoparticle Organ-Targeting Outcomes
… delivery of LNPs results from interactions with plasma proteins involved in endogenous cholesterol transport. Building on this foundation, I characterized the targeting mechanism of selective organ targeting (SORT) nanoparticles, an LNP platform for tissue-specific RNA delivery to …
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Genetic determinants of the human plasma proteome and their application in biology and disease
Proteins are the primary functional units of biology and the direct targets of most drugs, yet there is limited knowledge of the genetic factors determining inter-individual variation in protein levels (protein quantitative trait loci (pQTLs)). Limitations in high-throughput proteomic measurement …
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Development and mechanistic analysis of in vivo liposomal nanoparticle delivery of siRNA and mRNA
… to lung endothelial cells. Examination of the plasma proteins bound to the LNPs revealed apolipoprotein (Apo) B and ApoE attached to the hepatocellular targeted LNPs, with serum albumin and fibrinogen were bound to the lung targeted LNPs, and ApoAl found on both types of LNPs. Subsequent in …
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Ameliorating the toxic side-effects of cisplatin by systematically modulating its metabolism in human plasma with chemoprotective agents
… (SEC) coupled on-line to an inductively coupled plasma atomic emission spectrometer (ICP-AES), the effect of three chemoprotective agents − sodium thiosulfate (STS), N-acetyl-L-cysteine (NAC) and D-methionine − were investigated on the metabolism of the Pt-based anti-cancer drug cis-platin (CP) …
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Metabolic, neurotoxic and immunotoxic effects of PFAAs and their mixtures on the proteome of plasma and head kidney from rainbow trout
… metabolomics were conducted on the blood plasma and head kidney tissue to evaluate differences in biological effect for congeners and mixtures. The mixture and PFOS exposures significantly altered the abundances of many plasma proteins involved in lipid metabolism and the nervous system. …
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Bedside Washing of Stored Red Blood Cells: A Simple Apparatus Based on Microscale Sedimentation in Normal Gravity
… Transfusion Reactions (ATR) due to residual plasma proteins. Unfortunately, conventional washing is bulky, expensive and laborious, due to concentrating washed units through centrifugation. In response, we developed a bedside RBC washer that utilizes gravitational sedimentation of RBCs within …
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Oxidative stress biomarkers in dementia
… to investigate markers of oxidative stress in AD plasma. Moreover, the oxidative status of specific proteins was investigated using both hypothesis driven and proteomic approaches. Results presented in this thesis suggest that global plasma protein oxidation levels are not different when AD and …
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Predicting the risk of progression in patients with thoracic aortic aneurysm
… I have created a unique dataset quantifying plasma proteins and PBMC-RNAs in a cohort of 50 AD patients with measurements of growth or clinical progression over 2 years. Analysis of my dataset indicates that: a) aortic size alone is not a good predictor of growth b) prediction of future …
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