Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Plasma membrane profiling"”.
-
CHIC2 and STUB1 regulate interferon-γ receptor cell surface expression
… in cell surface protein regulation, I performed ‘plasma membrane profiling’, an unbiased, quantitative proteomic approach to compare the cell surface protein abundance in wildtype vs CHIC2 knockout cells. CHIC2 deficiency increased cell surface expression of 61 proteins in THP-1 cells, 43% of …
-
Human Cytomegalovirus and the Neutrophil
… ex vivo, and will be further investigated using plasma membrane profiling by amino-oxybiotinylation and tandem mass tag mass spectrometry. This technique, used for the first time here in a primary cell type, allows quantitative proteomics to be performed for the first time in the neutrophil. This …
-
Functional Characterisation of Protein Degradation during Human Cytomegalovirus Infection
… glycoproteins out of the endoplasmic reticulum. Plasma membrane profiling experiments identified several proteins that are downregulated on the surface of LMAN2L deficient cells, including US2 target integrin alpha 6 (ITGA6), which proposed an alternative mechanism by which US2 prevents the …
-
An unbiased proteomic approach to identifying cell surface markers in neutrophils
… facilitate a wave of synchronised apoptosis. The plasma membrane proteome was assessed using tandem-mass-tag liquid chromatography-mass spectrometry (TMT-LC/MS) of apoptotic and time- and donor- matched non-apoptotic neutrophils, which allowed the identification of the plasma membrane proteins …