Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"Plasma cells"”.
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T-Bet Expressing B Cells With Distinct Residency And Functional Characteristics Give Rise To Plasma Cells
An increasing body of work shows that T-bet+ B cells play important roles in immune responses to infections a well as in autoimmune diseases. These studies investigate the kinetics, tissue distribution, and functions of T-bet+ B cells in a murine influenza infection model. Both T-bet+ and T-bet- …
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The interactions of tolerogenic dendritic cells, induced regulatory T cells and antigen-specific IgG1-secreting plasma cells in asthma
… IL-10-differentiated dendritic cells (DC) (DC10) leads to progressive and long-lasting full-spectrum asthma tolerance. However, little has been done in investigating a role for antigen-specific B cells in DC10-induced tolerance. In this study, we characterized the surface markers …
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The role of B lymphocytes, plasma cells and tertiary lymphoid structures in the immune microenvironment of Non-Small Cell Lung Cancer
Ο μη μικροκυτταρικός καρκίνος του πνεύμονα (Non-Small Cell Lung Cancer, NSCLC) αποτελεί τον συχνότερο τύπο καρκίνου του πνεύμονα, αντιπροσωπεύοντας περίπου το 85% όλων των περιπτώσεων καρκίνου του πνεύμονα. Η επίπτωση του NSCLC έχει παρουσιάσει πτωτική τάση τα τελευταία χρόνια, λόγω της βελτίωσης …
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ΑΝΟΣΟΙΣΤΟΧΗΜΙΚΗ ΜΕΛΕΤΗ ΤΗΣ ΚΑΤΑΝΟΜΗΣ ΤΟΥ ΕΚΚΡΙΤΙΚΟΥ ΠΑΡΑΓΟΝΤΑ (SC) ΚΑΙ ΤΩΝ ΑΝΟΣΟΣΦΑΙΡΙΝΩΝ IGA, IGG, IGM ΣΕ ΝΕΟΠΛΑΣΜΑΤΙΚΕΣ ΚΑΙ ΜΗ ΝΕΟΠΛΑΣΜΑΤΙΚΕΣ ΠΑΘΗΣΕΙΣ ΤΟΥ ΜΑΣΤΟΥ
… DEMONSTRATED BOTH IN THE CYTOPLASM OF THE TUMOR CELLS AND IN THE LUMINAL SECRETION. THEIR PRESENCE CORRELATED WITH THE DEGREE OF DIFFERENTIATION BUT WAS NOT RELATED TO TUMOR HISTOLOGY. STROMAL PLASMA CELLS IN WELL AND MODERATELY DIFFERENTIATED CARCINOMAS WERE FOUND TO BE PREDOMINANTLY OF THE IGA …
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The morphology and function of Peyer's patches in the dog
… phosphates positive enterocytes and scattered M cells with low alkaline phosphatase activity, ileal dome epithelia predominantly consisted of M cells and few enterocytes. The domes of PPs contained numerous IgG plasma cells and a few or moderate number of IgA plasma cells.
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Combination of Dasatinib and Dexamethasone targets the myeloma plasma cell through its interaction with the bone marrow microenvironment
… of osteoclast cytoskeleton and adhesion of plasma cells to the bone marrow microenvironment, would enhance tumour sensitivity to steroids.In plasma cells, combination of Dasatinib and dexamethasone at clinically relevant concentrations induced apoptosis of human myeloma cell lines and …
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Probing the sensitivity of autoantibody production to B cell depletion by Rituximab
… CD20 antigen, causes profound depletion of all B cells. When used in patients with autoimmune disease, IgG autoantibody titres often fall whilst serum IgG anti-tetanus toxoid antibody titres are unaffected. Antibodies of both these antibody specificities have features associated with production by …
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Monogenetic Immune Dysregulation Syndromes and their Effect on the Plasma Cell Compartment
… diseases, these interactions are altered. Plasma cells (PC) and their B cell progenitors, that play a key role in maintaining humoral and cellular memory, are impaired within these patients. We characterised different features of plasma cells in immune dysregulated individuals via flow …
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ΤΟ ΤΟΠΙΚΟ ΑΝΟΣΟΕΚΚΡΙΤΙΚΟ ΣΥΣΤΗΜΑ ΤΟΥ ΣΤΟΜΑΧΟΥ ΣΕ ΚΑΛΟΗΘΕΙΣ ΚΑΙ ΚΑΚΟΗΘΕΙΣ ΠΑΘΗΣΕΙΣ ΑΥΤΟΥ (ΑΝΟΣΟΙΣΤΟΧΗΜΙΚΗ ΜΕΛΕΤΗ)
… BETWEEN CANCER, BENIGN ULCER AND NORMAL STOMACH (PLASMA CELLS).
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Early Growth Response Protein 2 (EGR2) regulation of B cell differentiation in lupus-prone mice
… treatment. It involves abnormal activation of B cells, which produce pathogenic autoantibodies that contribute to inflammation and tissue damage in multiple organs. Therapeutic depletion of B cells in human lupus patients had mixed success due to the complex heterogeneity of B cell subsets, …
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Myeloma-osteoclast interactions as a therapeutic target for multiple myeloma bone disease
… differentiated B lymphocytes, also known as plasma cells, which are cells specialized in generating antibodies. MM is responsible for 35,000 diagnoses and 13,000 deaths in the US annually. While both malignant and non-malignant plasma cells specifically migrate to the bone marrow, myeloma is …
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ΕΠΙΔΡΑΣΗ ΤΟΥ ΦΟΡΒΟΛΙΚΟΥ ΕΣΤΕΡΑ ΤΡΑ ΣΕ ΑΝΘΡΩΠΙΝΑ ΛΕΥΧΑΙΜΙΚΑ ΛΕΜΦΟΚΥΤΤΑΡΑ
… THAT OF LARGE THYMIC BLASTS (ABOUT 50% OFTHE CELLS). 2) THE SDK CELL LINE, WHICH INCLUDES CELLS WITH EITHER THE PHENOTYPE OF MATURE B LYMPHOCYTES (60-70% OF THE CELL POPULATION) OR OF PLASMACYTOID OR PLASMA CELLS (THE REMAINING CELLS. IT HAS BEEN FOUND THAT TPA, AT THE CONCENTRATION OF 16NM, …
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A Characterisation and Understanding of the Germinal Centre B Cell Response to Atherosclerosis in Mice using Lineage Tracing
… by low density lipoprotein cholesterol. Elevated plasma LDL is a major risk factor for atherosclerosis and its immunogenic oxidation creates neo-epitopes that drive inflammatory immune responses underlying the pathogenesis of atherosclerosis. The germinal centre is found within secondary lymphoid …
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Changes in peripheral B cell subsets under immunosuppressive therapy
… may progress to chronic autoimmune diseases. B cells play an important role in the pathogenesis of autoimmune diseases and influence autoimmunity through multiple pathways. With the availability of informative B cell surface markers it is now possible to identify within the circulating B cell …
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Biogenesis of Membrane-Bound and Secreted Immunoglobulins
… (Igs). The subpopulation of lymphoid cells that synthesize these molecules are so defined as members of the B lineage; the end-stage cell type of this lineage is the plasma cell. The acceptance, over the past thirty years, of myeloma proteins as normal products of plasma cells in …
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Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… characteristic of SLE, including peripheral plasma cell accumulation, anti-dsDNA antibodies, and GN. Lyn is a Src-family tyrosine kinase that, in general, inhibits B cell and myeloid cell activity. Loss of Lyn results in cellular hyperactivity associated with autoantibody production. Bruton’s …
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KSHV Susceptibility and Transmission Within Tonsillar Specimens
… Furthermore, the highly specific targeting of plasma cells is not due to CD138 (Syndecan-1) being used as an attachment factor, and heparan sulfates, in general, do not play an important role in KSHV infection of B cells. Finally, the donor-dependent immunological factors and immune status of …
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Influence of Human and Viral IL-6 on KSHV Infection in Human Tonsil Lymphocytes
<p>Infection of B cells by the lymphotropic gamma-herpesvirus Kaposi sarcoma-associated herpesvirus (KSHV) causes Multicentric Castleman Disease, Primary Effusion Lymphoma, and the newly-identified inflammatory syndrome designated KICS. Despite proven connections to lymphoproliferative disorders, …
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Impact of the parasitic helminth Schistosoma mansoni on host anti-viral vaccine responses: proof of concept from the anti-polio vaccine
… and increased cell death, of bone marrow plasma cells and plasma blasts in schistosomiasis-diseased mice. Notably, schistosomiasis reduced memory T cell responses as well in vaccinated hosts and considerably impaired the expression of survival markers on antibody-producing long term plasma …
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Modelling the affinity maturation of B lymphocytes in the germinal centre
… of the germinal centre that enables the B cells to move and interact with other cells inside the germinal centre. This allows the modelling of the affinity maturation of the B cells to produce high affinity antibodies. The model was validated against the available published population …
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