Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Plaque rupture"”.
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The mechanics of atherosclerotic plaque rupture
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1992.
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A Fluid Structure Interaction Model Of Intracoronary Atherosclerotic Plaque Rupture
Plaque rupture with superimposed thrombosis is the primary cause of acute coronary syndromes of unstable angina, myocardial infarction and sudden death. Although intensive studies in the past decade have shed light on the mechanism that causes unstable atheroma, none has directly addressed the …
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Impact of Percutaneous Transluminal Intervention on Vascular Hypoxia and the Role of Micro-calcifications on Atherosclerotic Plaque Rupture
… which evolves into a fibroatheroma, a lipid-rich plaque covered by a fibrous cap. Many of these plaques are considered as vulnerable, as they grow to occlude the luminal section of the artery (chronically stenotic) or become mechanically unstable with a higher chance of rupturing (rupture-prone). …
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Classification of atherosclerotic plaque vulnerability by mechano-radiomics
… resonance (MR) images can help evaluate carotid plaque vulnerability better than conventional MR methods. Hemodynamic forces have long been associated with the destabilization of developed plaques near regions of complex blood flow e.g., the carotid bifurcation, which results in high wall shear …
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A Novel Quantitative Mechanical Test of Atherosclerotic Plaque Stability
<p>Atherosclerotic plaque rupture is a major cause of myocardial infarction and stroke. The adhesive strength of the bond between the plaque and the vascular wall, measured as local energy release rate, G, was used for quantitative plaque stability estimation in mouse models. Towards the long-range …
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Biomechanical Analysis of Human Coronary Atherosclerotic Plaques in Response to Pharmacotherapy, and in Predicting Adverse Clinical Events
… worldwide, is often the result of coronary plaque rupture. Previous histological work has demonstrated that ruptured plaques are associated with higher stress, with in vivo intravascular studies linking higher plaque structural stress (PSS) with the presentation of acute coronary syndrome. …
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Platelet Receptor Glycoprotein VI in Ischaemic Stroke
… ischaemic stroke. At sites of atherothrombotic plaque rupture, it is established that platelet surface receptor glycoprotein (GP) VI-dimer binds to exposed sub-endothelial collagen, initiating the signalling required to cause platelet activation. Then, separate platelet-fibrin interactions cause …
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Development of a Vascularized Carotid Artery Plaque Phantom for the Investigation of Novel Ultrasound-Based Technologies
… detection and diagnosis of atherosclerotic plaques, and for quantitative measures of disease progression. Vulnerable plaque lesions are thought to be responsible for the majority of cardiovascular events, characterized by a large lipid core, a thin fibrous cap, and neovascularization – …
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Role of von Willebrand factor in shear induced platelet accumulation in a microfluidic device
… fluid shear rates at the site of atherosclerotic plaque rupture leads to myocardial infarction and stroke. At high shear rates, thrombus is formed by platelets adhering via the glycoprotein von Willebrand factor (vWF). To investigate the relative contributions of vWF and platelets in high shear …
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Imaging atherosclerotic plaque inflammation with [18F]- fluorodeoxyglucose positron emission tomography
… the pathogenesis and outcome of atherosclerosis. Plaques containing numerous inflammatory cells, particularly macrophages, have a high risk of rupture, whereas those with fewer inflammatory cells are at lower risk. The current ‘gold standard’ technique for imaging atherosclerosis is x-ray contrast …
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The role of hydrodynamic interactions in the dynamics and viscoelasticity of actin networks
… OCT (optical coherence tomography) and assess plaque rupture risk for cardiovascular diagnosis. The method can also be used as a model-based registration technique.Key words: Actin, Hydrodynamic Interactions, Relaxation Time, Cytoskeleton, Rod Model, Brownian Dynamics, Viscoelasticity, …
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Carotid Atherosclerosis: Why Some Patients are Symptomatic and Others Not?
… is a disease where there is build up of plaque in the blood vessel wall. Advanced plaque typically consists of lipid, such as cholesterol, a necrotic core and calcification, surrounded by cells and connective tissue matrix. Over the course of many years, build up of plaque material can …
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Investigating the role of macrophages in larval zebrafish heart regeneration
… becomes occluded following atherosclerotic plaque rupture. Consequently, the myocardium suffers ischemic cell death, manifesting as a region of necrotic cardiomyocytes in the left ventricle. Unfortunately, the human heart is unable to replace these lost cardiomyocytes, and this can lead to …
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Application of magnetic resonance elastography to atherosclerosis
… and stroke, are caused by ischemia due to local plaque rupture. The risk of rupture is related to the mechanical properties of the plaque. Magnetic resonance elastography (MRE) images tissue elasticity by inverting, externally excited, harmonic wave displacement into a stiffness map, known as an …
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Regulation of Protein Kinases (Syk and PKC zeta) in platelets
… is disrupted due to injury or atherosclerotic plaque rupture, one of the earliest responses to arrest the bleeding is the adhesion of circulating platelets to the exposed subendothelial collagen matrix. Subsequent intracellular signaling mediated downstream of various receptor systems leads to …
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Novel molecular imaging of cardiovascular disease in man
… majority of deaths are caused by atherosclerotic plaque rupture with resultant myocardial infarction or stroke, or rupture of abdominal aortic aneurysms. Conventional imaging modalities have consistently failed to identify atherosclerotic plaques or aneurysms with high-risk pathological features …
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Investigation Into The Role Of Biomechanical Forces In Determining The Behaviour of Coronary Atherosclerotic Plaques
… leading cause of death throughout the world. Rupture of an advanced atheromatous coronary plaque precipitates the majority of these clinical events, resulting in thrombosis and myocardial infarction. Post-mortem studies have identified thin-cap fibroatheroma (TCFA) as the plaque subtype most …