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Showing 1 to 4 of 4 for “"Plantazolicin (PZN)"”.
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Biosynthetic engineering of plantazolicin natural products
Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified peptide (RiPP) natural product that exhibits extraordinarily narrow-spectrum antibacterial activity towards the causative agent of anthrax, Bacillus anthracis. During PZN biosynthesis, a cyclodehydratase catalyzes …
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Structure and function analysis of the natural product plantazolicin, a bacillus anthracis-specific antibiotic
… the molecular mass of 1335 Daltons called plantazolicin (PZN). I describe the genetic locus responsible for the biosynthesis of PZN, which is ribosomally synthesized via an amino acid precursor peptide and post-translationally modified to contain thiazoles and (methyl)oxazoles. This group …
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Discovery and characterization of ribosomally synthesized and post-translationally modified peptide natural products
… and mode of action of newly discovered RiPPs. Plantazolicin (PZN) is a RiPP natural product with a rigid, polyheterocyclic structure and a remarkably species-specific antibiotic activity, targeting the pathogen Bacillus anthracis. While the highly modified natural product bears the …
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Cellular responses to external threats probed by super-resolution microscopy
… and narrow-spectrum antibiotics draw attention. Plantazolicin (PZN) is a natural antibiotic that is highly specific against B. anthracis which is the agent of anthrax and a category A priority pathogen, but the mechanism of how PZN kills B. anthracis has been unknown. Recent investigation showed …