Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Plant-derived compounds"”.
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Investigation of plant derived compounds mediating cell signalling effectson FOXO1a and AMPK
… in origin. This project has highlighted plant compounds and extracts with:<br/>Insulin-like properties in cell culture experiments in that they induce phosphorylation and therefore inactivation of the transcription factor FOXO1a, which is a major downstream effector insulin …
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Investigating the anti-inflammatory effects of plant derived compounds in tuberculosis using the THP-1 macrophage model
… with advanced TB. Repurposed drugs and plant-derived compounds with antiinflammatory effects have been explored for potential use as HDT's. Objectives To evaluate the anti-inflammatory effects of plant-derived compounds in macrophages infected with live Mtb strain H37Rv. Results We found …
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An assessment of Hypoxis hemerocallidea extracts, and actives as natural antibiotic, and immune modulation phytotherapies
… antibiotic alternatives with phytotherapies and plant-derived compounds as potentially promising alternatives. The main objective of this study was to investigate the antimycobacterial activity of Hypoxis hemerocallidea, a South African medicinal plant, using Mycobacterium smegmatis.
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Characterization of perillyl alcohol as a cell migration-inhibiting compound
… in a large-scale drug screen for anti-migration compounds. Using these assays, we measured the cytotoxicity and migration-inhibiting effect of dimethyl sulfuoxide, a drug solvent, in three cancer and one non-cancer cell lines. Next, we investigated plant-derived compounds called monoterpenes, …
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A Novel Phytoestrogen that Acts as an Agonist for Human Estrogen Receptors.
… of the estrogen receptor (ER). However, certain plant-derived compounds or phytoestrogens have been identified that mimic estrogens and act as agonists and/or antagonists of ERs, depending on subtype and target tissue. Understanding how phytoestrogens interact with ERs, and therefore effect the …
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Natural product chemistry in drug discovery
… the discovery and biological evaluation of plant-derived specialized metabolites as potential drug leads, and the verification of their botanical sources to ensure chemical and taxonomic accuracy. It comprises three publications. The first is a literature review of structure-dependent …
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Assessing Hepatic Gene Expression in Response to Xenobiotic Exposure in Mice
Xenobiotics are plant derived compounds metabolized by phase I and II liver enzymes. Phase I enzymes increase, and phase II enzymes decrease, xenobiotic toxicity. Xenobiotics considered were ergotamine, associated with fescue toxicosis, and sulforaphane, a phase II inducer. Hypothesized responses …
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Expression and analysis of a legumain from trichomonas vaginalis
… unprocessed TvAEl proteins. Thirdly, plant derived compounds, sanguinarine (SA) and chelerythrine (CHE) were assessed in vitro for their inhibitory effects against T vagina/is and T. foetus. Treatment of SA and CHE for 24 h led to a significant inhibitory growth of in vitro cultures …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… body weight; sibutramine, an antiobesity agent; plant-derived compounds (pinitol and chamaemeloside) and agents known to affect insulin sensitivity, e.g. metformin, tolbutamide, thiazolidinediones, vanadyl sulphate and thioctic acid. Models used for investigation included the L6 skeletal muscle …
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A Comparative Study of Medicago truncatula Transcriptomes as They Relate to Saponin Defenses Against Insect Pests
<p>Triterpene saponins are a class of defensive plant-derived compounds, which have a</p> <p>variety of functions including antimicrobial, insecticidal, and nematicidal activities. This</p> <p>research assessed the performance of the beet armyworm, Spodoptera exigua, following ad</p> <p>libero …
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Mechanisms of terrestrial organic carbon export and preservation in the marine environment
… G-B basin, in agreement with previously assessed plant-derived compounds, highlighting that an overarching soil stabilization mechanism controls the age of exported terrestrial organic matter. Individual biomarkers and bulk geochemical analysis chronicle the change in methane-derived soil carbon …
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Mechanisms of terrestrial organic carbon export and preservation in the marine environment
… G-B basin, in agreement with previously assessed plant-derived compounds, highlighting that an overarching soil stabilization mechanism controls the age of exported terrestrial organic matter. Individual biomarkers and bulk geochemical analysis chronicle the change in methane-derived soil carbon …
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Listeria monocytogenes in the mushroom production environment: biofilm formation and control measures
… active ingredients such as peracetic acid or plant-derived compounds could be effective alternative biocides for the mushroom industry. Interestingly, a reduction in efficacy was observed from the biocidal products when tested on concrete floors within the mushroom production environment. …