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Showing 1 to 20 of 39 for “"Planarian"”.
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Mechanisms of self-organization in planarian regeneration
… on the wing of a butterfly, a regenerating planarian eye, development of a neuronal circuit in the human brain can all be studied systematically using the conceptual tools derived from the field of self-organization. Here, I sought to address a central, but understudied, problem in animal …
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Regeneration and maintenance of the planarian nervous system
Planarians can regenerate all tissues, including the central nervous system and the eyes. This process depends on a population of cells in the adult, the neoblasts, that includes pluripotent stem cells. Whether the neoblast population also includes progenitors specialized for forming specific …
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Neoblast specialization during regeneration of the planarian S. mediterranea
Planarians are well known for their ability to regenerate an entire animal from small tissue fragments. Planarian regeneration requires a population of dividing cells called neoblasts that are distributed throughout the body. Historically, neoblasts have been considered a homogeneous population of …
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Branching out: how a planarian neoblast generates cellular diversity
The extraordinary regenerative capacity of planarians is derived from their large population of pluripotent stem cells called neoblasts. Neoblasts are a heterogenous population of stem cells that begin unspecified, but are rapidly specified within a single cell cycle and give rise to every cell in …
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The instructive roles of muscle cells in planarian regeneration
… information to correctly place new tissue. Planarians are flatworms with remarkable capacity to regenerate after nearly any injury and to indefinitely maintain tissue homeostasis. Dividing cells, neoblasts, are the source of all new tissue, whereas positional information is hypothesized to …
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MECHANISMS DRIVING PLANARIAN STEM CELLS TO EVADE RADIATION-INDUCED APOPTOSIS
… two independent ways in which stem cells in planarians, flatworms that are inherently resistant to cancer, can survive radiation. Planarians have a large population of stem cells that rapidly proliferate and are essential for regeneration. These cells are also ordinarily radio-sensitive, and …
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Functional genomic studies of regeneration in the planarian Schmidtea mediterranea
Regenerative capabilities are seen in varying degrees throughout the phylogenetic tree. Are the genes and signaling pathways employed by regeneration found in all metazoans and recruited by mechanisms conserved in regenerative organisms, or have organisms developed ways to recruit them de novo? We …
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Comprehensive single-cell transcriptional profiling of the regenerative planarian Schmidtea mediterranea
… cell types and cell states in a complete animal. Planarians are freshwater flatworms renowned for their capacity for whole-body regeneration. They possess a complex body plan with multiple distinct tissues. They also possess a population of dividing cells, called neoblasts, which contain …
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Regulation of fate specification in stem cells of the planarian Schmidtea mediterranea
… of cell types. Neoblasts are stem cells of the planarian Schmidtea mediterranea that undergo fate specification to produce over 125 adult cell types. Fate specification in neoblasts can be regulated through expression of fate-specific transcription factors. We utilize multiplexed error-robust …
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Dissecting the molecular mechanisms of germ cell development in the planarian Schmidtea mediterranea
… studying additional animal models. Freshwater planarian provides a unique system for studying germ cell development: these animals appear to form their germline post-embryonically from neoblasts, the totipotent stem cells of the species. In this study, we aim to systematically investigate germ …
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Characterization of the hermaphroditic reproductive system and sexual development in the planarian Schmidtea mediterranea
… There are two strains of the freshwater planarian, Schmidtea mediterranea: the sexual strain is a cross-fertilizing hermaphrodite with reproductive organs that develop post-embryonically; the asexual strain reproduces by transverse fission and does not develop reproductive organs. This …
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Establishment and maintenance of pattern at the ends of the planarian anterior-posterior axis
… patterns is a longstanding question in biology. Planarians, flatworms capable of remarkable whole-body regeneration, are well suited for the study of patterning. They are adept at establishing pattern in new tissues during regeneration and maintaining pattern of existing tissues during …
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Cellular and genetic mechanisms of new tissue production in the regenerating planarian Schmidtea mediterranea
… such as the replacement of amphibian limbs or planarian heads, require both a source for new cellular material as well as mechanisms to specify, differentiate, and pattern the regenerate. The planarian Schmidtea mediterranea is a classic system for studies of regenerative biology in which …
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Identification of pluripotent stem cells and characterization of glia in the planarian Schmidtea mediterranea
Given their regenerative capacity, the planarian Schmidtea mediterranea has emerged as a model system for the study of stem cell biology, tissue specification, and axis formation. Many aspects of the regenerative machinery have yet to be characterized. Although it is known that neoblasts, the …
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Somatic regulation of germ cell development in the planarian Schmidtea mediterranea: the role of systemic and local factors
The student, Amir Saberi, accepted the attached license on 2016-07-12 at 15:54.
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Functional Analysis of Genes Involved in Regulating Stem Cell Maintenance and Differentiation in the Freshwater Planarian Schmidtea Mediterranea
Freshwater planarians have been a classic model for regeneration studies for more than 250 years. The great regenerative abilities of planarians rely on neoblasts, adult stem cells maintained throughout the animal's life. This thesis reports an analysis of genes that regulate stem cell maintenance …
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Validation of the Planarian Bioassay With Defined Mixtures and Testing Against Other Bioassays With Contaminated Samples From Pakistan
… of this study were to: (a) develop the planarian model to assess toxicologic effects caused by pure chemicals and chemical mixtures; (b) assess chemical contamination in environmental samples from selected areas in Pakistan where industrial contamination was suspected; (c) test the …
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Mechanisms of tissue-specific regeneration in planarians
… a fundamental question of developmental biology. Planarian flatworms regenerate from diverse injuries, in each case precisely restoring body parts to their appropriate proportions. Underlying this ability is a pluripotent population of dividing cells called neoblasts, which are required for …
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teashirt is required for head-versus-tail regeneration polarity in planarians
… role in specifying posterior cell fates during planarian regeneration. We identified a gene encoding a homolog of the Teashirt family of zinc finger proteins in the planarian Schmidtea mediterranea to be a target of Wnt signaling in intact animals and at posterior-facing wounds. Inhibition of …
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The Effect of Caffeine and Ethanol on Flatworm Regeneration.
<p>Flatworms, or planarian, have a high potential for regeneration and have been used as a model to investigate regeneration and stem cell biology for over a century. Chemicals, temperature, and seasonal factors can influence planarian regeneration. Caffeine and ethanol are two widely used drugs …
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