Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Placental dysfunction"”.
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Mutationsanalyse der Gene PlGF und FLT1 bei Patientinnen mit IUGR und ARED-Flow im Doppler der A. umbilicalis
The development of the fetoplacental system, i.e. capillary sprouting as well as the switch from branching to non-branching angiogenesis, in human pregnancy is essential for the birth of a healthy infant at term. This angiogenic process is controlled by growth factors such as bFGF, VEGF and PlGF. …
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Chronic Gestational Inflammation: Comparisons of Obesity-Mediated and Preeclampsia-Mediated Placental Inflammation using Transcriptomic and Histological Methods
… these divergent chronic inflammatory insults on placental development and function remain elusive. Preliminary work by our group suggests placental NAD+ depletion and subsequent mitochondrial dysfunction may be common pathophysiology features. Using rodent MO- and PE-mediated gestational …
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Preeclampsia Link to Gestational Hypoxia
… diagnosis and treatment. Preeclampsia is a placental disorder originating from impaired spiral artery remodelling and resulting in increased placental vascular resistance, reduced uteroplacental perfusion, triggering placental hypoxia and oxidative stress. In turn, placental dysfunction is …
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Unsupervised Multi-Scale Analysis for the Identification of Placental Subtypes of Human Preeclampsia and Fetal Growth Restriction
… both thought to be primarily driven by placental dysfunction. Despite decades of research into the underlying etiologies of these disorders, as well as potential biomarkers and treatments, no single discovery has been found to be applicable to the entire clinical spectrum of PE or FGR …
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Fetal Cardiac Function and Venous Circulation - Experiences with Velocity Vector Imaging
Placental dysfunction resulting in intrauterine growth restriction (IUGR) is a common complication of pregnany and severe IUGR, with ensuing fetal hypoxia is an important cause of perinatal mortality and morbidity. Doppler studies of fetal and maternal vessels are routinely used for fetal …
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Characterisation of the role of mitochondrial dysfunction and meta-inflammation as a shared pathogenic network in gestational diabetes mellitus
… of GDM is complex, adipose tissue dysfunction is an established cause of metabolic dysfunction and systemic insulin resistance. Furthermore, the placental microenvironment is highly sensitive to GDM physiology and there is significant evidence that the hyperglycaemic state of GDM …
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Acetyl-CoA metabolism and human trophoblast differentiation
… process can lead to impaired placentation or placental dysfunction leading to complications in pregnancy. This thesis investigates the role of ATP citrate lyase (ACLY), an enzyme that links glucose metabolism to histone acetylation by producing acetyl-CoA, a substrate for epigenetic …
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Role of obesity and gestational diabetes mellitus status on the expression of kisspeptin, inflammatory markers and other endocrine signals, and their correlation with foetal outcomes and placental structure
… obesity and GDM and their interaction on placental kisspeptin and inflammatory marker (TNFα, IL-6) expression, the relationship between placental and circulatory kisspeptin and inflammatory markers with placental villous morphology and maternal and neonatal parameters. There is also a …