Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Placental development"”.
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The impact of advanced maternal age on endometrial differentiation and placental development
… the oocyte and may instead be linked to abnormal development of the placenta. In this thesis, I show that advanced maternal age in the mouse is associated with a drastically increased variability of developmental progression in utero, including developmental delays and growth restriction, severe …
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The role of Cited2 in left-right patterning and placental development in the mouse
… transcriptional factors to drive the proper development of many organs in the mouse. Territories of Cited2 expression in the mouse coincide with the tissues most affected in Cited2 null mice. Embryos deficient in Cited2 display complex heart defects that may have multiple origins. One …
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The effects of leptin on placental development and function, and offspring behavior in mice
… hormone also plays a role in implantation and placental development and function, as well as programming behavior via alteration of brain function. The current research provides insight into how leptin is involved in placental and fetal development. The goal of the first study was to determine …
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Understanding the effects of maternal undernutrition in early gestation on placental development in late gestation
… (MUN) during earlygestation permanently alters placental development, the mechanism by whichthis occurs, and whether leptin acts as a mediator.The relationship between the maternal environment and long-term healthof offspring is referred to as the developmental origins of health and disease …
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The role of thyroid hormones in placental development and the importance of the thyroid hormone transporter MCT8
Thyroid hormones (THs) are important for fetoplacental development. Human intrauterine growth restriction (IUGR) is associated with malplacentation and reduced fetal circulating concentration of THs. The expression of the plasma membrane TH transporters MCT8, MCT10, LAT1, LAT2, OATP1A2 and OATP4A1 …
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Effects of mid-gestational L-citrulline supplementation to twin-bearing ewes on umbilical blood flow, placental development, and lamb production traits
… short- and long-term consequences on health and development after birth. In some cases, these changes may be detrimental to the individual, but in other cases these developmental changes may be beneficial and manipulated to produce desired effects. Our interest is to use this concept of fetal …
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Creation of an Instructional Animation Showing the Development of the Human Placenta from Implantation to Term
… project was created to fill a need in available placental development instructional tools. In the current literature, there are few three-dimensional representations of placental villous tree structure. This animation provides an overview of placental development and includes a three-dimensional …
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The role of Thyroid hormone Transporters Monocarboxylate Transporter 10 (MCT10) and Monocarboxylate Transporter 8 (MCT8) in extravillous trophoblasts.
Thyroid hormones (TH) are important for fetal and placental development. Monocarboxylate transporters 8 and 10 (MCT8, MCT10) are effective plasma membrane TH transporters expressed in the human placenta from 6 weeks of gestation. Both have been localized to human villous trophoblasts and …
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Acetyl-CoA metabolism and human trophoblast differentiation
… process can lead to impaired placentation or placental dysfunction leading to complications in pregnancy. This thesis investigates the role of ATP citrate lyase (ACLY), an enzyme that links glucose metabolism to histone acetylation by producing acetyl-CoA, a substrate for epigenetic …
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Expression and secretion of basigin by human placental trophoblast cells occurs via microvesicle shedding and is a regulated process
… an adequate blood supply for normal fetal and placental development. Failure of sufficient trophoblast invasion and defective remodeling of the maternal uterine spiral arteries is linked to the obstetrical disease preeclampsia. Trophoblast invasion and spiral artery remodeling are influenced by …
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Role of Endoplasmic Reticulum Stress in Trophoblast Stem Cell Differentiation
… of trophoblast stem cells (TSCs), placental development, and subsequent pregnancy outcome. To address this question, I first used an in vitro mouse TSC model. Morphological observations suggest that upon ER stress, TSCs lose stemness by differentiating into specialized trophoblast …
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Control of Cardiac and Limb Development by the bHLH Transcription Factors DHAND and eHAND
… of multiple cell lineages during embryonic development. The bHLH proteins dHAND and eHAND are expressed in complimentary and overlapping patterns during embryogenesis, and gene knockout studies have demonstrated that dHAND and eHAND null embryos die from defects in right ventricular and …
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The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation
… The currently accepted mechanism underlying the development of preeclampsia implicates poor trophoblast invasion and inadequate transformation of the maternal spiral arteries. Despite extensive research in this area, the control of trophoblast invasion and early placental development remains …
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Folate Receptor-Targeted Transplacental Delivery of Digoxin for the Treatment of Fetal Arrhythmia
… This condition is typically treated with transplacental digoxin by maternal administration. However, maternal digoxin administration is associated with nausea, vomiting, heart block and sinus bradycardia. Additionally, placental efflux mechanisms limit the transfer of digoxin to the fetus. When …
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The role of FKBPL in diabetes and associated cardiovascular health
… diabetes in vivo, and 3) investigate the role of placental FKBPL in pregnancies complicated by diabetes or pre-eclampsia.<br/><br/>Our in vitro data demonstrated that FKBPL knockdown in endothelial cells under baseline conditions was associated with abnormal expression of proteins which have …
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Endometrial Decidualization by TGF-β and PPAR-γ
… nuclear receptor. PPAR-γ is essential for normal placental development and trophoblast differentiation and invasion. Our data demonstrated the expression of PPAR-γ in the stromal cell and TGF-β and PPAR-γ did the conflicting role in human cultured endometrial decidualization. CONCLUSION: There was …
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Macrophage Diversity in the First Trimester Human Placenta: Phenotypes, Functions and Developmental Origins
… Hofbauer cells (HBC), however the functions and developmental origins of these cells remain poorly defined. Our attempts to profile HBC in the first trimester human placenta revealed the presence of maternally-derived cells in placental digests. We established reliable gating strategies for the …
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Evaluation of Carbon Monoxide as a Therapeutic for Preeclampsia
… accepted to occur in two stages: poor uteroplacental perfusion and placental ischemia, which subsequently leads to a systemic maternal inflammatory response and multi-organ effects. Although cigarette smoking during pregnancy is known to cause aberrant placental development and adverse …
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Chronic Gestational Inflammation: Comparisons of Obesity-Mediated and Preeclampsia-Mediated Placental Inflammation using Transcriptomic and Histological Methods
… these divergent chronic inflammatory insults on placental development and function remain elusive. Preliminary work by our group suggests placental NAD+ depletion and subsequent mitochondrial dysfunction may be common pathophysiology features. Using rodent MO- and PE-mediated gestational …
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… heparin-binding growth factors (HBGFs) in normal placental development was altered in a specific pregnancy disorder preeclampsia. HBGFs bind to heparin, a glycosaminoglycan (GAG) affecting activity. I investigated the role of heparin and HBGFs in pathophysiology of pre-eclampsia. Placental tissue …
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