Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Placental cells"”.
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Tissue-Specific Expression and Steroid Hormone Regulation of Human Gonadotropin -Releasing Hormone (hGnRH) Gene in Placental Cells (JEG -3 cells)
<p>Using JEG-3 cells as an <em>in vitro</em> model, I investigated the mechanisms behind the tissue-specific expression and steroid hormone regulation of the hGnRH gene in the human placenta. The hGnRH upstream promoter was found to be functionally active in JEG-3 cells. The DNA sequence …
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The role of thyroid hormones in placental development and the importance of the thyroid hormone transporter MCT8
Thyroid hormones (THs) are important for fetoplacental development. Human intrauterine growth restriction (IUGR) is associated with malplacentation and reduced fetal circulating concentration of THs. The expression of the plasma membrane TH transporters MCT8, MCT10, LAT1, LAT2, OATP1A2 and OATP4A1 …
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The role of Cited2 in left-right patterning and placental development in the mouse
… in many trophoblast subtypes and vascular cells. Cited2 deficient placentas are grossly small in size, with reduced trophoblast numbers and an expanded foetal vasculature. This part of the study further characterised the cellular expression of Cited2 in placental cells. It also further …
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The expression of Heat Shock Protein 70 in the placental tissue with preeclampsia
OBJECTIVE: Placental ischemia caused by abnormal trophoblastic invasion to spiral arteries, immunologic intolerance and inflammatory change explain etiology of preeclampsia. As a consequence, inflammatory cells are released and they induce oxidative stress contributing to endothelial dysfunction …
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Downregulation of reproductive homeobox gene 6 (RHOX6) interferes with male germ cell differentiation
… the Rhox family, is expressed in primordial germ cells (PGCs) in the developing gonad and the placenta, although the biological function of Rhox6 in determination of PGCs and placental cells remains unknown. To investigate the Rhox6 function, we generated male chimeras by injection of the …
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Ire1 regulates cyp11a1 transcription to mediate steroidogenesis in the ovary
… an ER stress response is not induced in KGN cells by forskolin treatment. We hypothesize that IRE1 is necessary to mediate CYP11A1 transcription in response to forskolin, a gonadotropin mimetic, in a mechanism independent to its role in ER stress. In the human KGN granulosa cell line, IRE1 is …
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Human Gonadotropin-Releasing Hormone (hGnRH) Gene Expression and Hormone Regulation in Human Placental JEG-3 Cells
<p>Using the human placental choriocarcinoma JEG-3 cell line as an <em>in vitro</em> human placental model, I studied the mechanisms of the tissue-specific expression and steroid hormone regulation of the hGnRH gene in the human placenta. The results showed that all of the previously identified …
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Differential expression of C/T antigens and 5-HT receptors in normotensive and pre-eclamptic placentae, and their role in trophoblast invasion
… that are prominently expressed in cancer cells of different histological origin. Placenta is one of the three non-cancerous tissues known to express these antigens. During the first trimester (FT) of pregnancy, placental invasion resembles to that in tumour, and is controlled by several …
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Trophoblast Retrieval And Isolation From The Cervix (tric) For Non-Invasive Prenatal Genetic Diagnosis And Prediction Of Abnormal Pregnancy Outcome
… of pregnancy, extravillous trophoblast (EVT) cells invade the uterus and remodel the maternal spiral arteries, which, if inadequate, leads to pregnancy complications, including early pregnancy loss (EPL), preeclampsia (PE), and intra-uterine growth restriction (IUGR). EVT migration into the …