Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Placental Growth factor"”.
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Impacts of Placental Growth Factor Deficiency and of Preeclampsia on Brain Development and Function
… PE pregnancies, maternal plasma is low in the placentally-produced angiokine “placental growth factor” (PGF). Offspring of PE (PE-F1) compared to uncomplicated pregnancies have higher risks for hypertension, cognitive impairment, and stroke. However, mechanisms explaining these risks are poorly …
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Regulating the bioactivity of placental growth factor in the aging outer retina as a new therapeutic approach to age-related macular degeneration
… are no clinically available treatments for GA. Placental growth factor (PlGF) is a seemingly dispensable member of the VEGF family, in normal physiology. However, it has been shown to propagate retinal pathology in animal models. Reports also suggest that PlGF can induce epithelial cell …
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Placental growth factor; potential for its use in twin pregnancy and evaluation of its benefit in singletons with suspected preterm pre-eclampsia
… of a hypertensive disorder of pregnancy. Placental growth factor is an angiogenic protein highly expressed during pregnancy. The pro-angiogenic/anti-angiogenic synergism of PlGF and its receptors is critical for successful placentation in early pregnancy. Circulating maternal levels of …
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Comparison of Revvity soluble fms-like tyrosine kinase-1 and Placental Growth Factor methods on the DELFIA Xpress with Roche methods on the cobas e411: in a patient cohort with suspected preeclampsia as defined by NICE
… soluble fms-like tyrosine kinase-1 (sFlt-1) and placental like growth factor (PlGF), are increasingly used to support the diagnosis of preeclampsia in routine clinical practice. There are an increasing number of methods available for the analysis of these markers but data showing the …
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Platelet micro-particles induce angiogenesis through the delivery of the micro-RNA Let-7a into endothelial cells
… which is linked to athero-thrombosis. The risk factors for atherothrombosis, thus cardiovascular disease is impaired anti-thrombotic and antiinflammatory functions of the endothelium. Thrombosis is a hallmark of cardiovascular disease/complications characterised by increased platelet activation …
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Mechanisms of Hypoxia-Induced Neurovascular Remodeling in PlGF Knockout Mice
… levels. In brain hypoxia, vascular endothelial growth factor (VEGF) plays a critical role in angiogenesis; however, the role of its homolog placental growth factor (PlGF) is unknown. Using PlGF knockout (PlGF-/-) mice exposed to whole body hypoxia (10% oxygen) for 7, 14 and 21-days, we show that …
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… hypothesis that expression of heparin-binding growth factors (HBGFs) in normal placental development was altered in a specific pregnancy disorder preeclampsia. HBGFs bind to heparin, a glycosaminoglycan (GAG) affecting activity. I investigated the role of heparin and HBGFs in pathophysiology of …
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Modeling of interactions between vascular endothelial growth factor family members and their receptors KDR and Flt-1
The vascular endothelial growth factor (VEGF) family is prominently involved in angiogenesis, the formation of new vasculature. Overexpression has been linked to pathological conditions including solid tumor growth. Responses to VEGF are mediated by Flt-1 and KDR, two cell-surface receptors …
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Vascular Effects of Low-Molecular Weight Heparin in Pregnant Women at High-Risk of Preeclampsia
… to controls. Baseline plasma and urine levels of placental growth factor (PlGF) were significantly lower in high-risk women compared with controls. These findings demonstrate that pregnant women at high-risk of PE exhibit impaired endothelial function prior to the clinical presentation of PE. The …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Vascular Fetal Programming in a Mouse Model of Preeclampsia
… is believed to be caused by an imbalance between placental perfusion and placental metabolic needs. The hypoxic placenta releases factors into the maternal circulation, causing dysfunctional maternal endothelium, and resulting in blood pressure increase and end organ damage. Pregnancies destined …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Fetal Vascular Programming in a Mouse Model of Preeclampsia
… is believed to be caused by an imbalance between placental perfusion and placental metabolic needs. The hypoxic placenta releases factors into the maternal circulation, causing dysfunctional maternal endothelium, and resulting in blood pressure increase and end organ damage. Pregnancies destined …
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Evaluating the Expression of Angiogenic Mediators in a Mouse Model of Tumor Metastasis
… the development of new blood vessels, for growth and metastasis. Vascular endothelial growth factor (VEGF) induces angiogenesis by activating receptors on host endothelial cells. One such receptor, Flt-1, occurs as either a membrane bound or a secreted form (sFlt-1) that can inhibit …
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Modified polyethylene glycol hydrogels for growth factor delivery and controlled tissue invasion
… of potentially cardioprotective and regenerative growth factors from biomaterial scaffolds. One hydrogel system that has promise in this area is an injectable enzymatically degradable polyethylene glycol (PEG) hydrogel. Two modifications aimed at further optimising this system as a regenerative …
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Examining The Role Of Angiogenic Factors And Early Developmental Defects In The Pathogenesis Of Pre-Eclampsia In A Mouse Model, Bph/5
… the symptoms of PE as well as many of the placental pathologies associated with the human condition. As the pathogenesis of PE is known to start before the symptoms begin, this disease is very difficult to study in women. As such, this mouse model is invaluable in examining early pregnancy …
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Evaluation of suboptimal health status and prospective levels of oxidative stress biomarkers and angiogenic growth mediators with placental anatomy and pathology in normotensive and preeclamptic births
… oxidative stress (OS) biomarkers and angiogenic growth mediators (AGMs) with placental anatomy and pathology in normotensive and preeclamptic births in a Ghanaian Population. This longitudinal nested case-control study was based on the Ghanaian Suboptimal Health Status Cohort Study (GHOACS) that …
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Evaluating the role of PLGF and VEGFR-1/ Flt-1 in the development of cervical intraepithelial neoplasia and invasive cervical carcinoma in the background of HIV infection in women living in South Africa
… hr-HPV infection is the primary etiological factor, the molecular mechanisms underlying progression from low-grade squamous intraepithelial lesions (LSIL) to high grade intraepithelial lesions (HSIL) and invasive carcinoma remain incompletely understood. Angiogenesis within the tumour …
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Pregnancy associated progenitor cells migrate, integrate and contribute to maternal hematopoietic compartments in the murine model
… between mother and fetus during pregnancy of placental animals is a commonly observed phenomenon. Fetal cells transferred to mothers are termed as Pregnancy Associated Progenitor Cells (PAPCs) and their presence in maternal tissues is known as fetomaternal microchimerism (FMM). FMM has been …
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Sex differences in human perinatal development and autism
… sex steroid theory by investigating perinatal factors related to sex differences in physiology. Study 1 (described in Chapter 2) reports a case-control analysis of steroid levels in the amniotic fluid of males who were later diagnosed as autistic, linked with the Danish Biobank (n = 98 cases, n …
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ANGIOTENSIN-(1-7): A NOVEL SMALL MOLECULE FOR THE TARGETED TREATMENT OF TRIPLE NEGATIVE BREAST CANCER
… and have basal expression of the human epidermal growth factor receptor 2 (HER2), severely limiting therapeutic strategies. The purpose of this study was to determine whether angiotensin-(1-7) [Ang-(1-7)], an endogenous peptide hormone that activates the AT(1-7) receptor mas, inhibits the growth …
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