Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 317 for “"Placental"”.
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Placental (Mal)Adaptation in Maternal Obesity: Immune-Mediated Regulation of Placental Nutrient Partitioning and Fetal Growth
… maternal obesity, and inflammation may disrupt placental nutrient partitioning potentially leading to fetal growth restriction. To address this, both murine and in vitro models were employed. Mice were fed a high-fat high-sugar (HFHS) diet 9-weeks prior to and throughout pregnancy to create a …
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Maternal and placental adaptations to hypoxia
… gas pressure, will induce maternal and placental-driven responses that are responsible for compensatory mechanisms facilitating oxygen delivery to the fetus. We observed changes in placental gene expression, uteroplacental vasculature, maternal red blood cell parameters, and splenic gene …
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ROLES OF SULFOTRANSFERASE ENZYMES IN TRANS-PLACENTAL DISPOSITION
… the rate-determining barrier for trans-placental transfer. Several isoforms of the sulfotransferase enzymes are functional in placenta but there is only limited information available on the utility of cultured trophoblast cells for studying placental sulfation. We examined the expression …
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Axis of placental ageing in adverse pregnancy outcomes
… a result of various genetic, environmental, or placental factors. Premature ageing of the placenta in pregnancy outcomes such as PE and IUGR is associated with the persistent presence of oxidative stress and placental insufficiency reducing its functional capacity. Placental proteomics has been …
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Environmental factors affecting human and rat placental lactogen.
Thesis: M.S., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1975
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UNDERSTANDING PLACENTAL IMMUNITY: CYTOKINE CONTROL OF CONGENITAL VIRAL INFECTION
… infection, certain viruses can traverse the placental barrier, establish infection in the fetus, and cause adverse pregnancy outcomes or congenital disease. To combat this, the placenta has evolved potent defenses including the constitutive secretion of antiviral factors called cytokines. …
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Modern iatrogenics: some studies on placental transfer of drugs
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Placental epigenetic modifications and development in valproic acid-induced teratogenesis
… Evidence suggests that VPA can also cause placental toxicity, which may serve as an important mechanism of VPA-induced teratogenicity. The purpose of this thesis was to investigate the effect of VPA on placental epigenetics, as well as placental growth and development, in the CD1 mouse …
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Placental angiogenesis and immune-privilege in normal and pathological pregnancies
… that diminished levels were associated with placental insufficiency. Moreover, experiments using hypoxia provided evidence for significantly enhanced expression and secretion of angiogenin with a concomitant loss of VCAM-1, thus indicating a role for these pivotal peptides in IUGR. Additional …
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Placental infarction: in its relation to the toxaemias of pregnancy
… shows a definite increase in the percentage of placental tissue infarcte the longer the duration of the hypertension. There were 15 cases of accidental haemorrhage in this series. The study of this small group reveals the following facts; - I. Of twelve cases of accidental haemorrhage …
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Studies on the gonadotrophic hormones of pituitary and placental origin
In the early part of this century there was much controversy about the existence nature and number of pituitary gonadotrephins. The era of gonadotrophic studies started when in 1897 Heaps postulated the possible existence of an extra-ovarian factor capable of regulating ovarian activity. His …
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The metabolism of cortisol in the human feto-placental unit
… 3) respectively. Kinetic parameters of the human placental 11β-hydroxysteroid dehydrogenase system were assessed using a microsomal preparation in 50% glycerol buffer. The Michaelis constant for cortisol was 1.88 x 10-6M, in the presence of NADP, and 0.56 x 10-6M, in the presence of NAD. Vmax …
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The Placental Microbiome and Preterm Birth: An Evolutionary Life History Perspective
This work sequenced the placental microbiome of preterm and full-term pregnancies, and related preterm/full-term variations in placental microbiome composition and function to maternal inflammation in order to evaluate the proximate roles of the placental microbiome in responding to maternal immune …
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Precision-cut placental slices as a model to study inflammatory response
Univerzita Karlova Farmaceutická fakulta v Hradci Králové Katedra farmakologie a toxikologie Student: Bahareh Bolboli Školitel: Prof. PharmDr. František Štaud, Ph.D. Konzultant: Kasin Yadunandam AnandamPh.D., Ph.D. Název diplomové práce: Placentární řezy jako model pro studium zánětlivé odpovědi. …
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Placental P-glycoprotein: Role in disposition of medications administered during pregnancy
… circulation. Active efflux transporters in the placental apical membrane are involved in placental elimination of compounds and thus fetal protection. The goal of this investigation was to evaluate developmental and genetic influences on expression and activity of the placental efflux …
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Food Habits and Placental Scar Counts of Bobcats in South Dakota
Bobcat (Lynx rufus) food habits and placental scar counts were investigated in western South Dakota during 1978-79 and 1979-80 trapping and hunting seasons. Food habits were recorded by frequency of occurrence and placental scar counts were used to determine litter size for South Dakota bobcats. …
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The Effect of Exercise-induced Myokines on Placental Health and Function
… during pregnancy. 2) First trimester human placental explants (N=5) were treated with SPARC in a dose-dependent manner (0-150ng/ml). Metrics of placental health/function, including GLUT-4 expression/regulation, were assessed. Results: 1) Active women demonstrated an elevation in circulating …
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Studies into the release mechanisms of human placental lactogen in vitro
… hormone biosynthesis, was measured by incubating placental fragments in physiological salt solutions for short periods. The effect of test substances and different ionic environments on HPL release were tested to ascertain the roles of calcium ion and cyclic AMP in the release mechanism. 2. The …
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