Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"PlGF"”.
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Mechanisms of Hypoxia-Induced Neurovascular Remodeling in PlGF Knockout Mice
… the role of its homolog placental growth factor (PlGF) is unknown. Using PlGF knockout (PlGF-/-) mice exposed to whole body hypoxia (10% oxygen) for 7, 14 and 21-days, we show that PlGF-/- animals exhibit a delay in the angiogenic response of the brain to hypoxia. PlGF-/- microvessels had a …
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Mutationsanalyse der Gene PlGF und FLT1 bei Patientinnen mit IUGR und ARED-Flow im Doppler der A. umbilicalis
… by growth factors such as bFGF, VEGF and PlGF. The interaction of PlGF with FLT1 seems to induce non-branching angiogenesis and this type of angiogenesis predominates in pregnancies with intrauterine growth retardation (IUGR) and ARED (absent or reversed enddiastolic)-flow (postplacental …
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Regulating the bioactivity of placental growth factor in the aging outer retina as a new therapeutic approach to age-related macular degeneration
… treatments for GA. Placental growth factor (PlGF) is a seemingly dispensable member of the VEGF family, in normal physiology. However, it has been shown to propagate retinal pathology in animal models. Reports also suggest that PlGF can induce epithelial cell dysfunction and its inhibition …
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Evaluating the role of PLGF and VEGFR-1/ Flt-1 in the development of cervical intraepithelial neoplasia and invasive cervical carcinoma in the background of HIV infection in women living in South Africa
… mediated by placental growth factor (PLGF) and its receptor vascular endothelial growth receptor (VEGFR1/Flt-1), has been implicated in cervical carcinogenesis, yet their expression patterns across lesions to disease are poorly characterised. This study evaluated the expression …
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Comparison of Revvity soluble fms-like tyrosine kinase-1 and Placental Growth Factor methods on the DELFIA Xpress with Roche methods on the cobas e411: in a patient cohort with suspected preeclampsia as defined by NICE
… (sFlt-1) and placental like growth factor (PlGF), are increasingly used to support the diagnosis of preeclampsia in routine clinical practice. There are an increasing number of methods available for the analysis of these markers but data showing the comparability of their analytical …
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Placental growth factor; potential for its use in twin pregnancy and evaluation of its benefit in singletons with suspected preterm pre-eclampsia
… The pro-angiogenic/anti-angiogenic synergism of PlGF and its receptors is critical for successful placentation in early pregnancy. Circulating maternal levels of placental growth factor correlate well with placental function. Women presenting with suspected pre-eclampsia are currently triaged …
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Vascular Effects of Low-Molecular Weight Heparin in Pregnant Women at High-Risk of Preeclampsia
… and urine levels of placental growth factor (PlGF) were significantly lower in high-risk women compared with controls. These findings demonstrate that pregnant women at high-risk of PE exhibit impaired endothelial function prior to the clinical presentation of PE. The acute cardiovascular …
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Análisis de la circulación cerebral fetal mediante power doppler tridimensional en gestaciones complicadas con diabetes gestacional y su relación con el estado proinflamatorio materno
… Se encontraron diferencias en el ratio sFlt-1/PlGF entre los grupos (P =0,04). Se encuentra correlación negativa entre los niveles de PlGF y el IP medio de las arterias uterinas (r= -0,5, p=0,01) y corrleación positiva con el índice cerebropacentario-uterino (r=0,45, p=0,01). Se encuentra …
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Estudio multidisciplinar de potenciales marcadores precoces de preeclampsia: estudio en muestras de sangre obtenidas en el primer trimestre de gestantes sanas y con preeclampsia
… fue evaluar si biomarcadores maternos clásicos (PlGF, sFlt-1, ?-hCG y PAPP-A) y novedosos (ADNlc y MPc), medidos durante el primer trimestre, permiten predecir el desarrollo posterior de preeclampsia (PE) y sus complicaciones graves. Metodología: Se realizó un estudio retrospectivo de casos y …
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Ο ρόλος της λιποπρωτεΐνης (α) και του λιπιδαιμικού profile επιτόκων στην προεκλαμψία
… παράγοντα sFlt-1 και μειωμένα επίπεδα του PlGF, οδηγώντας σε συστηματική ενδοθηλιακή δυσλειτουργία. Παράλληλα, αυξανόμενα δεδομένα υποδηλώνουν ότι το λιπιδαιμικό προφίλ της κύησης και ιδιαίτερα η λιποπρωτεΐνη (α) ενδέχεται να διαδραματίζουν σημαντικό ρόλο στην επιδείνωση της αγγειακής …
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Utilidad de los biomarcadores séricos en el diagnóstico y pronóstico de los estados hipertensivos del embarazo.
… valores séricos de los biomarcadores (sFtl-1, PlGF, ácido úrico, cistatina C e interleucina-6) se analizaron posteriormente a la finalización de la gestación y no intervinieron por tanto en el manejo clínico de la misma. Resultados: Las gestantes con diagnóstico de PE mostraron diferencias …
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Ο ρόλος της Βιταμίνης D στην προεκλαμψία
… μητρικό αίμα με τον αγγειογενετικό δείκτη sFlt-1/PlGF, στο πλαίσιο της ισχαιμικής νόσου του πλακούντα και των συνακόλουθων διαταραχών της μητρικής και εμβρυϊκής κυκλοφορίας, όπως η προεκλαμψία και η ενδομήτρια καθυστέρηση ανάπτυξης. Η μελέτη ήταν προοπτικού χαρακτήρα, διάρκειας δύο ετών, και …
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… growth factor (VEGF), placental growth factor (PLGF), fibroblast growth factor 2 (FGF2), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF), heparin-binding epidermal growth factor (HB-EGF), midkine (MK), pleiotrophin (PTN), and cluster differentiation (CD105). The …
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Nuevos marcadores en el diagnóstico y pronóstico de la preeclampsia precoz y tardía
… angiogénesis (factor de crecimiento placentario, PlGF; forma soluble de la tirosina quinasa-1, sFlt-1 y cociente sFlt-1/PlGF) y de un marcador cardiovascular (fragmento amino-terminal del pro-péptido natriurético tipo B, NT-proBNP) en comparación con los marcadores clásicamente utilizados …
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Modified polyethylene glycol hydrogels for growth factor delivery and controlled tissue invasion
… factor (VEGF) and placental growth factor 2 (PlGF-2), and also assaying endothelial cell sprouting in an in vitro 3D spheroid angiogenesis assay. The second modification involved overlaying an increasingly hydrolytic degradability on top of the enzymatically degradable background of the …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Vascular Fetal Programming in a Mouse Model of Preeclampsia
… factor (VEGF) and placental growth factor (PlGF), have been shown to play an important role in the vascular physiologic changes occurring during pregnancy; therefore, inhibition of their function is believed to be one of the mechanisms leading to preeclampsia. One of the inhibitors of these …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Fetal Vascular Programming in a Mouse Model of Preeclampsia
… factor (VEGF) and placental growth factor (PlGF), have been shown to play an important role in the vascular physiologic changes occurring during pregnancy; therefore, inhibition of their function is believed to be one of the mechanisms leading to preeclampsia. One of the inhibitors of these …
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Evaluating the Expression of Angiogenic Mediators in a Mouse Model of Tumor Metastasis
… directed against sFlt-1, Flt-1, KDR, VEGFA, PlGF (Placental Growth Factor), Angiotensin Converting Enzyme (ACE), 18S ribosomal RNA and neoR (neomycin phosphotransferase). We observed an increased sFlt-1:Flt-1 ratio in tumor-bearing versus control lungs, suggesting that tumor-derived signals …
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